4-FORMYL-N-CBZ-PIPERIDINE

Product Name: 4-FORMYL-N-CBZ-PIPERIDINE
CAS No.: 138163-08-3
Chemical Name: 4-FORMYL-N-CBZ-PIPERIDINE
Synonyms: BENZYL 4-FORMYLPIPERIDINE-1-CARBOXYLATE;BENZYL 4-FORMYLTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;CAS:138163-08-3;BUTTPARK 92\50-59;1-Z-4-formylpiperidine;Cbz-4-forMyl-piperidine;N-CBZ-4-FORMYLPIPERIDINE;4-FORMYL-N-CBZ-PIPERIDINE;1-Cbz-4-forMyl-piperidine;1-Cbz-4-Piperidine Carboxaldehyde
CBNumber: CB9402432
Molecular Formula: C14H17NO3
Formula Weight: 247.29
MOL File: 138163-08-3.mol

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4-FORMYL-N-CBZ-PIPERIDINE Property

Boiling point:: 384.5±42.0 °C(Predicted)
Density: 1.22g/ml
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form: liquid
pka: -2.18±0.40(Predicted)
color: Clear, beige
InChI: InChI=1S/C14H17NO3/c16-10-12-6-8-15(9-7-12)14(17)18-11-13-4-2-1-3-5-13/h1-5,10,12H,6-9,11H2
InChIKey: ZJQMLJFHCKTCSF-UHFFFAOYSA-N
SMILES: N1(C(OCC2=CC=CC=C2)=O)CCC(C=O)CC1
CAS DataBase Reference: 138163-08-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-24/25
Hazard Note: Irritant
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: F697785
Product name: 4-Formyl-N-Cbz-piperidine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: F697785
Product name: 4-Formyl-N-Cbz-piperidine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 072723
Product name: N-Cbz-piperidine-4-carbaldehyde
Purity: 95+%
Packaging: 5g
Price: $53
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140330
Product name: Benzyl 4-formylpiperidine-1-carboxylate
Packaging: 5G
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: W3011
Product name: 1-Cbz-4-PiperidineCarboxaldehyde
Packaging: 10g
Price: $131
Updated: 2021/12/16

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4-FORMYL-N-CBZ-PIPERIDINE Chemical Properties,Usage,Production

Uses

4-Formyl-N-Cbz-piperidine is a useful reagent for the preparation of pyrimidinyltetrahydropyridoindoles as estrogen receptor degrading PROTACs.

Synthesis

122860-33-7

138163-08-3

The general procedure for the synthesis of 4-formyl-N-CBZ piperidine from N-CBZ-4-piperidine methanol (1-CBZ-4-hydroxymethylpiperidine) was as follows: Step 3: Synthesis of benzyl 4-formyl-piperidine-1-carboxylate (3); Oxalyl chloride (59.1 mL, 674 mmol) was dissolved in dichloromethane (500 mL) and the solution was cooled to -78 °C. The solution was then dissolved in dichloromethane (500 mL). Dimethyl sulfoxide (68.3 mL, 963 mmol) was added slowly with stirring and stirring was continued for 15 minutes. Subsequently, benzyl 4-hydroxymethyl-piperidine-1-carboxylate (2) (120 g, 481 mmol) dissolved in dichloromethane (500 mL) was added. The reaction mixture was slowly warmed to -55 °C and kept at this temperature for 15 minutes. After that, the mixture was again cooled to -78 °C and a solution of dichloromethane (250 mL) of triethylamine (205 mL, 1443 mmol) was slowly added. The reaction suspension was allowed to warm slowly to room temperature and the reaction was quenched with glacial acetic acid (100 mL). The reaction solution was washed with water and the aqueous phase was back-extracted with dichloromethane (2 x 200 mL). All organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to afford benzyl 4-formyl-piperidine-1-carboxylate (119 g, 100% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 19, p. 2663 - 2666
[2] Patent: WO2007/93603, 2007, A1. Location in patent: Page/Page column 15
[3] Patent: WO2014/22349, 2014, A1. Location in patent: Paragraph 00158
[4] Chinese Chemical Letters, 2012, vol. 23, # 6, p. 661 - 664
[5] Organic and Biomolecular Chemistry, 2017, vol. 15, # 46, p. 9830 - 9836

4-FORMYL-N-CBZ-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-FORMYL-N-CBZ-PIPERIDINE Suppliers

Belgium 1 China 180 France 3 Germany 2 India 5 United Kingdom 6 United States 25 Global 222

Shanghai Hobor Chemical Co., Ltd

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Energy Chemical

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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View Lastest Price from 4-FORMYL-N-CBZ-PIPERIDINE manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 4-FORMYL-N-CBZ-PIPERIDINE 138163-08-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-09-24

Honest Joy Holdings Limited

Product: 4-Formyl-N-cbz-piperidine 138163-08-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.3%
Supply Ability: 100 tons
Release date: 2022-01-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-FORMYL-N-CBZ-PIPERIDINE 138163-08-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

138163-08-3, 4-FORMYL-N-CBZ-PIPERIDINERelated Search:

4-HYDRAZINOCARBONYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER Benzyl 4-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 4-FORMYL-N-CBZ-PIPERIDINE 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Benzyl formate 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE 4-AMINO-1-CBZ-PIPERIDINE-4-CARBOXYLIC ACID 3-OXO-3-(1-CBZ-PIPERIDIN-4-YL)-PROPIONIC ACID ETHYL ESTER BENZYL 4-([(2-METHOXY-2-OXOETHYL)AMINO]CARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 3-METHYL-PIPERIDINE-1,4-DICARBOXYLIC ACID 1-BENZYL ESTER 4-TERT-BUTYL ESTER BUTTPARK 93\50-42 3-(1-(BENZYLOXYCARBONYL)PIPERIDIN-4-YL)-3-OXOPROPANOIC ACID BUTTPARK 93\50-41 T-BUTYL N-CBZ-4-PIPERIDINECARBOXYLATE 1-[(9H-FLUOREN-9-YLOXY)CARBONYL]PIPERIDINE-4-CARBOXYLIC ACID

4-Formylpiperidine, N-CBZ protected

BUTTPARK 92\50-59

BENZYL 4-FORMYLTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

N-CBZ-4-PIPERIDINYLCARBOXALDEHYDE

N-CBZ-4-FORMYLPIPERIDINE

Piperidine-4-carboxaldehyde, N-CBZ protected

Benzyl 4-formyltetrahydro-1(2H)-pyridinecarboxylate, 90+%

1-Cbz-4-Piperidine Carboxaldehyde

4-FORMYL-N-CBZ-PIPERIDINE

4-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

N-(Benzyloxycarbonyl)-4-carboxypiperidine, min. 96 %

BENZYL 4-FORMYLPIPERIDINE-1-CARBOXYLATE

1-(Benzyloxycarbonyl)-4-piperidinecarboxaldehyde

1-Piperidinecarboxylic acid, 4-formyl-, phenylmethyl ester

N-(Benzyloxycarbonyl)-4-carboxypiperidine

2-benzyl-4-forMylpiperidine-1-carboxylate

1-Cbz-4-forMyl-piperidine

4-Formylpiperidine, N-CBZ protected 98%

Benzyl 4-formylpiperidine-1-carboxylate, 1-[(Benzyloxy)carbonyl]-4-formylpiperidine

CAS:138163-08-3

1-Z-4-formylpiperidine

4-Formyl-piperidin-1-carboxylic acid benzyl ester

BENZYL 4-FORMYL-1-PIPERIDINECARBOXYLATE

Cbz-4-forMyl-piperidine

Benzyl 4-formyl-piperidin-1-carboxylate

138163-08-3

Carbonyl Compounds

Heterocycles