ChemicalBook > CAS DataBase List > 4-FORMYL-N-CBZ-PIPERIDINE

4-FORMYL-N-CBZ-PIPERIDINE

Product Name
4-FORMYL-N-CBZ-PIPERIDINE
CAS No.
138163-08-3
Chemical Name
4-FORMYL-N-CBZ-PIPERIDINE
Synonyms
BENZYL 4-FORMYLPIPERIDINE-1-CARBOXYLATE;BENZYL 4-FORMYLTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;CAS:138163-08-3;BUTTPARK 92\50-59;1-Z-4-formylpiperidine;Cbz-4-forMyl-piperidine;N-CBZ-4-FORMYLPIPERIDINE;4-FORMYL-N-CBZ-PIPERIDINE;1-Cbz-4-forMyl-piperidine;1-Cbz-4-Piperidine Carboxaldehyde
CBNumber
CB9402432
Molecular Formula
C14H17NO3
Formula Weight
247.29
MOL File
138163-08-3.mol
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4-FORMYL-N-CBZ-PIPERIDINE Property

Boiling point:
384.5±42.0 °C(Predicted)
Density 
1.22g/ml
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form 
liquid
pka
-2.18±0.40(Predicted)
color 
Clear, beige
InChI
InChI=1S/C14H17NO3/c16-10-12-6-8-15(9-7-12)14(17)18-11-13-4-2-1-3-5-13/h1-5,10,12H,6-9,11H2
InChIKey
ZJQMLJFHCKTCSF-UHFFFAOYSA-N
SMILES
N1(C(OCC2=CC=CC=C2)=O)CCC(C=O)CC1
CAS DataBase Reference
138163-08-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-24/25
Hazard Note 
Irritant
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
F697785
Product name
4-Formyl-N-Cbz-piperidine
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
F697785
Product name
4-Formyl-N-Cbz-piperidine
Packaging
500mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-CR
Product name
4-Formylpiperidine, N-Cbz protected
Packaging
1g
Price
$30
Updated
2021/12/16
Matrix Scientific
Product number
072723
Product name
N-Cbz-piperidine-4-carbaldehyde
Purity
95+%
Packaging
5g
Price
$53
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140330
Product name
Benzyl 4-formylpiperidine-1-carboxylate
Packaging
2g
Price
$60
Updated
2021/12/16
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4-FORMYL-N-CBZ-PIPERIDINE Chemical Properties,Usage,Production

Uses

4-Formyl-N-Cbz-piperidine is a useful reagent for the preparation of pyrimidinyltetrahydropyridoindoles as estrogen receptor degrading PROTACs.

Synthesis

122860-33-7

138163-08-3

The general procedure for the synthesis of 4-formyl-N-CBZ piperidine from N-CBZ-4-piperidine methanol (1-CBZ-4-hydroxymethylpiperidine) was as follows: Step 3: Synthesis of benzyl 4-formyl-piperidine-1-carboxylate (3); Oxalyl chloride (59.1 mL, 674 mmol) was dissolved in dichloromethane (500 mL) and the solution was cooled to -78 °C. The solution was then dissolved in dichloromethane (500 mL). Dimethyl sulfoxide (68.3 mL, 963 mmol) was added slowly with stirring and stirring was continued for 15 minutes. Subsequently, benzyl 4-hydroxymethyl-piperidine-1-carboxylate (2) (120 g, 481 mmol) dissolved in dichloromethane (500 mL) was added. The reaction mixture was slowly warmed to -55 °C and kept at this temperature for 15 minutes. After that, the mixture was again cooled to -78 °C and a solution of dichloromethane (250 mL) of triethylamine (205 mL, 1443 mmol) was slowly added. The reaction suspension was allowed to warm slowly to room temperature and the reaction was quenched with glacial acetic acid (100 mL). The reaction solution was washed with water and the aqueous phase was back-extracted with dichloromethane (2 x 200 mL). All organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to afford benzyl 4-formyl-piperidine-1-carboxylate (119 g, 100% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 19, p. 2663 - 2666
[2] Patent: WO2007/93603, 2007, A1. Location in patent: Page/Page column 15
[3] Patent: WO2014/22349, 2014, A1. Location in patent: Paragraph 00158
[4] Chinese Chemical Letters, 2012, vol. 23, # 6, p. 661 - 664
[5] Organic and Biomolecular Chemistry, 2017, vol. 15, # 46, p. 9830 - 9836

4-FORMYL-N-CBZ-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-FORMYL-N-CBZ-PIPERIDINE manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
4-FORMYL-N-CBZ-PIPERIDINE 138163-08-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-09-24
Honest Joy Holdings Limited
Product
4-Formyl-N-cbz-piperidine 138163-08-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99.3%
Supply Ability
100 tons
Release date
2022-01-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-FORMYL-N-CBZ-PIPERIDINE 138163-08-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

138163-08-3, 4-FORMYL-N-CBZ-PIPERIDINERelated Search:

4-HYDRAZINOCARBONYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER Benzyl 4-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 4-FORMYL-N-CBZ-PIPERIDINE 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Benzyl formate 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE 4-AMINO-1-CBZ-PIPERIDINE-4-CARBOXYLIC ACID 3-OXO-3-(1-CBZ-PIPERIDIN-4-YL)-PROPIONIC ACID ETHYL ESTER BENZYL 4-([(2-METHOXY-2-OXOETHYL)AMINO]CARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 3-METHYL-PIPERIDINE-1,4-DICARBOXYLIC ACID 1-BENZYL ESTER 4-TERT-BUTYL ESTER BUTTPARK 93\50-42 3-(1-(BENZYLOXYCARBONYL)PIPERIDIN-4-YL)-3-OXOPROPANOIC ACID BUTTPARK 93\50-41 T-BUTYL N-CBZ-4-PIPERIDINECARBOXYLATE 1-[(9H-FLUOREN-9-YLOXY)CARBONYL]PIPERIDINE-4-CARBOXYLIC ACID

  • 4-Formylpiperidine, N-CBZ protected
  • BUTTPARK 92\50-59
  • BENZYL 4-FORMYLTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
  • N-CBZ-4-PIPERIDINYLCARBOXALDEHYDE
  • N-CBZ-4-FORMYLPIPERIDINE
  • Piperidine-4-carboxaldehyde, N-CBZ protected
  • Benzyl 4-formyltetrahydro-1(2H)-pyridinecarboxylate, 90+%
  • 1-Cbz-4-Piperidine Carboxaldehyde
  • 4-FORMYL-N-CBZ-PIPERIDINE
  • 4-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
  • N-(Benzyloxycarbonyl)-4-carboxypiperidine, min. 96 %
  • BENZYL 4-FORMYLPIPERIDINE-1-CARBOXYLATE
  • 1-(Benzyloxycarbonyl)-4-piperidinecarboxaldehyde
  • 1-Piperidinecarboxylic acid, 4-formyl-, phenylmethyl ester
  • N-(Benzyloxycarbonyl)-4-carboxypiperidine
  • 2-benzyl-4-forMylpiperidine-1-carboxylate
  • 1-Cbz-4-forMyl-piperidine
  • 4-Formylpiperidine, N-CBZ protected 98%
  • Benzyl 4-formylpiperidine-1-carboxylate, 1-[(Benzyloxy)carbonyl]-4-formylpiperidine
  • CAS:138163-08-3
  • 1-Z-4-formylpiperidine
  • 4-Formyl-piperidin-1-carboxylic acid benzyl ester
  • BENZYL 4-FORMYL-1-PIPERIDINECARBOXYLATE
  • Cbz-4-forMyl-piperidine
  • Benzyl 4-formyl-piperidin-1-carboxylate
  • 138163-08-3
  • Carbonyl Compounds
  • Heterocycles