1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE

Product Name: 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE
CAS No.: 160809-38-1
Chemical Name: 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE
Synonyms: Ethyl 1-Cbz-piperidine-4-carboxylate;1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE;1-O-benzyl 4-O-ethyl piperidine-1,4-dicarboxylate;4-Ethyl 1-(phenylmethyl) 1,4-piperidinedicarboxylate;Piperidine derivative Ethyl-N-CBZ-piperidine-4-carboxylate;1,4-Piperidinedicarboxylic acid, 4-ethyl 1-(phenylMethyl) ester;piperidine-1,4-dicarboxylic acid O4-ethyl ester O1-(phenylmethyl) ester;Piperidine derivative CAS NO.160809-38-1 Ethyl-N-CBZ-piperidine-4-carboxylate
CBNumber: CB11516451
Molecular Formula: C16H21NO4
Formula Weight: 291.34
MOL File: 160809-38-1.mol

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1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE Property

Boiling point:: 403.7±45.0 °C(Predicted)
Density: 1.165±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -2.28±0.40(Predicted)
Appearance: Colorless to light yellow Liquid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E930615
Product name: EthylN-Cbz-piperidine-4-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: X0399
Product name: Ethyl-N-Cbz-piperidine-4-carboxylate
Packaging: 100g
Price: $249
Updated: 2021/12/16

AK Scientific

Product number: X0399
Product name: Ethyl-N-Cbz-piperidine-4-carboxylate
Packaging: 1g
Price: $73
Updated: 2021/12/16

AK Scientific

Product number: X0399
Product name: Ethyl-N-Cbz-piperidine-4-carboxylate
Packaging: 10g
Price: $91
Updated: 2021/12/16

Matrix Scientific

Product number: 130103
Product name: Piperidine-1,4-dicarboxylicacid1-benzylester4-ethylester
Purity: 95%+
Packaging: 5g
Price: $118
Updated: 2021/12/16

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1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE Chemical Properties,Usage,Production

Synthesis

1126-09-6

501-53-1

160809-38-1

The general procedure for the synthesis of ethyl 1-Cbz-piperidine-4-carboxylate from ethyl 4-piperidinecarboxylate and benzyl chloroformate was as follows: a solution of benzyl chloroformate (95 g, 0.56 mol) in dichloromethane (200 mL) was added slowly and dropwise to a stirred ethyl 4-piperidinecarboxylate (87 g, 0.55 mol) and sodium carbonate (60 g, 0.57 mol) mixture. The dropwise addition was controlled to be completed in 70 min, during which dichloromethane (200 mL) was added simultaneously. The reaction mixture was stirred continuously at room temperature for 2.5 days, followed by filtration through a Celte pad. The filtrate was concentrated under vacuum and the residue was partitioned between 2M aqueous hydrochloric acid and ether. The organic layer was separated, dried with anhydrous magnesium sulfate, filtered and concentrated. Finally, the residue was purified by silica gel column chromatography (eluent: ethyl acetate/isohexane) to afford the target product ethyl 1-Cbz-piperidine-4-carboxylate (152 g, 94% yield). The product was characterized by 1H NMR (360 MHz, CDCl3): δ 7.40-7.27 (5H, m), 5.12 (2H, s), 4.22-3.99 (2H, m), 4.40 (2H, q, J=7.4 Hz), 2.93 (2H, br t, J=11.6 Hz), 2.45 (2H, m), 1.97-1.81 (2H, m), 1.74-1.56 (2H, m), 1.25 (3H, t, J=7.4 Hz).

References

[1] Patent: WO2004/78750, 2004, A1. Location in patent: Page 64
[2] Patent: US2006/229289, 2006, A1. Location in patent: Page/Page column 21
[3] Patent: WO2007/93603, 2007, A1. Location in patent: Page/Page column 15
[4] Patent: EP1522540, 2005, A1. Location in patent: Page/Page column 63
[5] Patent: WO2015/118342, 2015, A1. Location in patent: Page/Page column 67; 68

1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE Suppliers

Canada 1 China 71 France 1 Germany 2 India 3 United States 8 Global 86

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View Lastest Price from 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE manufacturers

Career Henan Chemical Co

Product: 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE 160809-38-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-20

160809-38-1, 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATERelated Search:

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 1-Cbz-4-Piperidone 2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-Boc-Piperidine-4-carboxylic acid methyl ester Benzyl 2-methylpiperidine-1,2-dicarboxylate Ethyl N-Boc-piperidine-4-carboxylate ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE Ethyl 1-methylnipecotate Ethyl 1-methyl-4-piperidinecarboxylate Methyl N-methyl piperidine-4-carboxylate Ethyl 1-methylpipecolinate METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE Ethyl 1-benzylpiperidine-4-carboxylate 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Methyl 1-methylpiperidine-3-carboxylate 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE ETHYL 3-CBZ-3-AZA-BICYCLO[3.1.0]HEXANE-6-CARBOXYLATE

1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE

Ethyl 1-Cbz-piperidine-4-carboxylate

1,4-Piperidinedicarboxylic acid, 4-ethyl 1-(phenylMethyl) ester

Piperidine derivative Ethyl-N-CBZ-piperidine-4-carboxylate

piperidine-1,4-dicarboxylic acid O4-ethyl ester O1-(phenylmethyl) ester

Piperidine derivative CAS NO.160809-38-1 Ethyl-N-CBZ-piperidine-4-carboxylate

1-O-benzyl 4-O-ethyl piperidine-1,4-dicarboxylate

4-Ethyl 1-(phenylmethyl) 1,4-piperidinedicarboxylate

160809-38-1