ChemicalBook > CAS DataBase List > 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE

1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE

Product Name
1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE
CAS No.
160809-38-1
Chemical Name
1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE
Synonyms
Ethyl 1-Cbz-piperidine-4-carboxylate;1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE;1-O-benzyl 4-O-ethyl piperidine-1,4-dicarboxylate;4-Ethyl 1-(phenylmethyl) 1,4-piperidinedicarboxylate;Piperidine derivative Ethyl-N-CBZ-piperidine-4-carboxylate;1,4-Piperidinedicarboxylic acid, 4-ethyl 1-(phenylMethyl) ester;piperidine-1,4-dicarboxylic acid O4-ethyl ester O1-(phenylmethyl) ester;Piperidine derivative CAS NO.160809-38-1 Ethyl-N-CBZ-piperidine-4-carboxylate
CBNumber
CB11516451
Molecular Formula
C16H21NO4
Formula Weight
291.34
MOL File
160809-38-1.mol
More
Less

1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE Property

Boiling point:
403.7±45.0 °C(Predicted)
Density 
1.165±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-2.28±0.40(Predicted)
Appearance
Colorless to light yellow Liquid
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
E930615
Product name
EthylN-Cbz-piperidine-4-carboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
X0399
Product name
Ethyl-N-Cbz-piperidine-4-carboxylate
Packaging
100g
Price
$249
Updated
2021/12/16
AK Scientific
Product number
X0399
Product name
Ethyl-N-Cbz-piperidine-4-carboxylate
Packaging
1g
Price
$73
Updated
2021/12/16
AK Scientific
Product number
X0399
Product name
Ethyl-N-Cbz-piperidine-4-carboxylate
Packaging
10g
Price
$91
Updated
2021/12/16
Matrix Scientific
Product number
130103
Product name
Piperidine-1,4-dicarboxylicacid1-benzylester4-ethylester
Purity
95%+
Packaging
5g
Price
$118
Updated
2021/12/16
More
Less

1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE Chemical Properties,Usage,Production

Synthesis

1126-09-6

501-53-1

160809-38-1

The general procedure for the synthesis of ethyl 1-Cbz-piperidine-4-carboxylate from ethyl 4-piperidinecarboxylate and benzyl chloroformate was as follows: a solution of benzyl chloroformate (95 g, 0.56 mol) in dichloromethane (200 mL) was added slowly and dropwise to a stirred ethyl 4-piperidinecarboxylate (87 g, 0.55 mol) and sodium carbonate (60 g, 0.57 mol) mixture. The dropwise addition was controlled to be completed in 70 min, during which dichloromethane (200 mL) was added simultaneously. The reaction mixture was stirred continuously at room temperature for 2.5 days, followed by filtration through a Celte pad. The filtrate was concentrated under vacuum and the residue was partitioned between 2M aqueous hydrochloric acid and ether. The organic layer was separated, dried with anhydrous magnesium sulfate, filtered and concentrated. Finally, the residue was purified by silica gel column chromatography (eluent: ethyl acetate/isohexane) to afford the target product ethyl 1-Cbz-piperidine-4-carboxylate (152 g, 94% yield). The product was characterized by 1H NMR (360 MHz, CDCl3): δ 7.40-7.27 (5H, m), 5.12 (2H, s), 4.22-3.99 (2H, m), 4.40 (2H, q, J=7.4 Hz), 2.93 (2H, br t, J=11.6 Hz), 2.45 (2H, m), 1.97-1.81 (2H, m), 1.74-1.56 (2H, m), 1.25 (3H, t, J=7.4 Hz).

References

[1] Patent: WO2004/78750, 2004, A1. Location in patent: Page 64
[2] Patent: US2006/229289, 2006, A1. Location in patent: Page/Page column 21
[3] Patent: WO2007/93603, 2007, A1. Location in patent: Page/Page column 15
[4] Patent: EP1522540, 2005, A1. Location in patent: Page/Page column 63
[5] Patent: WO2015/118342, 2015, A1. Location in patent: Page/Page column 67; 68

1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE Suppliers

Canada 1 China 70 France 1 Germany 2 India 3 United States 8 Global 85
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
Rare Chemicals GmbH
Tel
--
Fax
--
Email
sales@rarechem.de
Country
Germany
ProdList
6297
Advantage
38
More
Less

View Lastest Price from 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE manufacturers

Career Henan Chemical Co
Product
1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE 160809-38-1
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-20

160809-38-1, 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATERelated Search:

1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid 1-Cbz-4-Piperidone 2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-Boc-Piperidine-4-carboxylic acid methyl ester Benzyl 2-methylpiperidine-1,2-dicarboxylate Ethyl N-Boc-piperidine-4-carboxylate ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE Ethyl 1-methylnipecotate Ethyl 1-methyl-4-piperidinecarboxylate Methyl N-methyl piperidine-4-carboxylate Ethyl 1-methylpipecolinate METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE Ethyl 1-benzylpiperidine-4-carboxylate 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Methyl 1-methylpiperidine-3-carboxylate 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE ETHYL 3-CBZ-3-AZA-BICYCLO[3.1.0]HEXANE-6-CARBOXYLATE

  • 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE
  • Ethyl 1-Cbz-piperidine-4-carboxylate
  • 1,4-Piperidinedicarboxylic acid, 4-ethyl 1-(phenylMethyl) ester
  • Piperidine derivative Ethyl-N-CBZ-piperidine-4-carboxylate
  • piperidine-1,4-dicarboxylic acid O4-ethyl ester O1-(phenylmethyl) ester
  • Piperidine derivative CAS NO.160809-38-1 Ethyl-N-CBZ-piperidine-4-carboxylate
  • 1-O-benzyl 4-O-ethyl piperidine-1,4-dicarboxylate
  • 4-Ethyl 1-(phenylmethyl) 1,4-piperidinedicarboxylate
  • 160809-38-1