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alpha-Lobeline hydrochloride

Product Name
alpha-Lobeline hydrochloride
CAS No.
134-63-4
Chemical Name
alpha-Lobeline hydrochloride
Synonyms
Lobelin Hydrochlorde;LOBELINE HYDROCHLORIDE;(-)-id;a-Lobeline;A-LOBELINE HCL;(-)-LOBELINE HCL;LOBELINE HCL, A-;Einecs 205-150-2;ALPHA-LOBELIN HCL;Lobeline HCl salt
CBNumber
CB9404885
Molecular Formula
C22H28ClNO2
Formula Weight
373.92
MOL File
134-63-4.mol
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alpha-Lobeline hydrochloride Property

Melting point:
183-185 °C (dec.)(lit.)
alpha 
D20 -43° (c = 2)
refractive index 
-57.5 ° (C=1, H2O)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: 25 mg/mL
form 
powder
color 
white to off-white
optical activity
[α]20/D 56.8°, c = 2 in H2O
Merck 
14,5551
BRN 
3920196
LogP
3.610 (est)
CAS DataBase Reference
134-63-4(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
23/25
Safety Statements 
36/37/39-45
RIDADR 
UN 1544 6.1/PG 3
WGK Germany 
3
RTECS 
OJ8490100
F 
8
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000112
Product name
Lobeline hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000112
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
141879
Product name
(?)-Lobeline hydrochloride
Purity
98%
Packaging
1g
Price
$304
Updated
2024/03/01
Cayman Chemical
Product number
29526
Product name
(–)-Lobelin (hydrochloride)
Packaging
250mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
29526
Product name
(–)-Lobelin (hydrochloride)
Packaging
500mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
29526
Product name
(–)-Lobelin (hydrochloride)
Packaging
1g
Price
$143
Updated
2024/03/01
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alpha-Lobeline hydrochloride Chemical Properties,Usage,Production

Description

(–)-Lobeline is an alkaloid that has been found in Lobelia and has diverse biological activities. It binds to nicotinic acetylcholine receptors (nAChRs) in rat brain homogenates (Ki = 4 nM) and has antinociceptive effects in the tail-flick assay in mice. (–)-Lobeline (0.3 and 0.9 mg/kg) reduces the number of errors in a repeated acquisition procedure in the radial arm maze in rats. It also decreases immobility time in the forced swim test and feeding latency in the novelty suppressed feeding test, indicating antidepressant-like activity, in mice when administered at doses of 1 and 4 mg/kg.

Chemical Properties

White to Off-White Solid

Uses

A neuronal nicotinic acetylcholine receptor agonist. A respiratory stimulant

Uses

A neuronal nicotinic acetylcholine receptor agonist. A CNS stimulant.

Biological Activity

High affinity nicotinic receptor ligand, with a K i value of 4.4 nM in rat brain.

in vitro

clastogenicity of lobeline and possible interactions between lobeline and ethyl alcohol were investigated in a mutagen-sensitivity assay on cultures of human lymphoblastoid cell lines. lobeline alone was not clastogenic, but there was a marked increase in genetic damage resulting from a coclastogenic interaction between lobeline and ethyl alcohol. [5]

in vivo

male c57bl/6j mice were individually housed and acclimatized to 10% alcohol. lobeline is a partial nicotinic agonist that attenuates alcohol consumption and preference in male c57bl/6j mice. [3] cf-1 male mice received an intraperitoneal injection of lobeline (5 or 10mg/kg). lobeline did not show genotoxic or mutagenic effects and did not increase the ethanol-induced genotoxic effects in blood. lobeline also protected blood cells against oxidative damage induced by hydrogen peroxide. [4]

alpha-Lobeline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from alpha-Lobeline hydrochloride manufacturers

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
Lobeline hydrochloride 134-63-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98% HPLC
Supply Ability
2 MTs
Release date
2024-05-15
Wuhan Monad Medicine Tech Co.,LTD
Product
Lobeline hydrochloride 134-63-4
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%min
Supply Ability
5000
Release date
2021-04-16
Dideu Industries Group Limited
Product
alpha-Lobeline hydrochloride 134-63-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-28

134-63-4, alpha-Lobeline hydrochlorideRelated Search:

Diethylstilbestrol N-Ethylmethylamine Lobeline Methyl salicylate 1-AdaMantanethylaMine 2'-Hydroxyacetophenone Kresoxim-methyl PHENYL VALERATE Thiophanate-methyl Topotecan hydrochloride Tribenuron methyl α-Lipoic Acid 3,4-Dihydroxyacetophenone 1-Hydroxyethylidene-1,1-diphosphonic acid 4-Ethyl-5-fluoro-6-hydroxypyrimidine 3'-Hydroxyacetophenone CHLOROPHOSPHONAZO III 3-Nitroacetophenone

  • (-)-id
  • 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-acetophenonhydrochlor
  • 2-[6-(.beta.-hydroxyphenethyl)-1-methyl-2-piperidyl]-,hydrochloride,(-)-Acetophenone
  • Lobelinhydrochloride
  • 2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone
  • Lobelin Hydrochlorde
  • 2-[6-(2-HYDROXY-2-PHENETHYL)-1-METHYL-2-PIPERIDYL]ACETOPHENONE HCL
  • 2-(6-[2-HYDROXY-2-PHENYLETHYL]-1-METHYL-2-PIPERIDINYL)-1-PHENYLETHANONE HYDROCHLORIDE
  • 2-[(2r,6s)-6-[(2s)-2-hydroxy-2-phenyl-ethyl]-1-methyl-2-piperidyl]-1-phenyl-ethanone hydrochloride
  • [2-[(2R,6S)-6-[(2S)-2-HYDROXYPHENETHYL]]-1-METHYL-2-PIPERIDYL]ACETOPHENONE HYDROCHLORIDE
  • (-)-LOBELINE HCL
  • LOBELINE HCL, A-
  • (-)-LOBELINE HYDROCHLORIDE
  • LOBELINE HYDROCHLORIDE
  • L-LOBELINE HYDROCHLORIDE
  • A-LOBELINE HCL
  • A-LOBELINE, HYDROCHLORIDE
  • ALPHA-LOBELINE HYDROCHLORIDE
  • ALPHA-LOBELIN HCL
  • 2-(6-(2-hydroxy-2-phenethyl)-1-methyl-2-piperidyl)acetophenone hydrochloride
  • 2-(6-[2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl)-1-phenylethanone, L-Lobeline, Hydrochloride
  • a-Lobeline
  • Lobeline HCl salt
  • Apolipoprotein B (LDL), Sheep anti-Human, Guinea pig, Swine (NO X w/Bovine, Horse, Dog, Cat, Rabbit, Chicken, Goat, Mouse, Rat)
  • 2-[(6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenylethanone
  • a-Lobeline Hydrochloride (L-Lobeline hydrochloride
  • 2-[6-(beta-Hydroxyphenylethyl)-1-methyl-2-piperidinyl]acetophenone hydrochloride
  • Acetophenone, 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-, hydrochloride, (-)-
  • Einecs 205-150-2
  • Ethanone, 2-((2R,6S)-6-((2S)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride
  • Ethanone, 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride, (2R-(2alpha,6alpha(S*))-
  • α-Lobeline Hydrochcloride
  • 2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenonehydrochloride
  • Lobeline hydrochloride ,99%
  • α-Lobeline hydrochloride,2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride, ()-Lobeline hydrochloride
  • 2-[1-chloro-6-(2-hydroxy-2-phenylethyl)-1-Methyl-1$l^{5}-piperidin-2-yl]-1-phenylethan-1-one
  • 2-[(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-Methyl-2-piperidinyl]-1-phenylethanone Hydrochloride
  • 2-[6-(2-hydroxy-2-phenylethyl)-1-Methylpiperidin-2-yl]-1-phenylethan-1-one hydrochloride
  • (-)-Lobeline hydrochloride, 2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride
  • α-Lobeline hydrochloride, L-Lobeline hydrochloride
  • 2-(6-(2-Hydroxy-2-phenylethyl)-1-Methylpiperidin-2-yl)-1-phenylethanone hydrochloride
  • Lobeline hydrochloride CRS
  • 2-((2R,6S)-6-((S)-2-Hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one hydrochloride
  • alpha-Lobeline hydrochloride USP/EP/BP
  • (-)-a-Lobeline Hydrochloride
  • Lobeline hydrochloride (C-07475)
  • α-Lobeline hydrochloride
  • Lobelinehydrochlonide
  • α-Lobeline Hydrochcloride
  • (-)-Lobeline hydrochloride
  • (–)-Lobelin (hydrochloride)
  • 2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone hydrochloride
  • (?)-Lobeline hydrochloride
  • 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethan-1-one hydrochloride
  • 134-63-4
  • C22H27NO2HCl
  • Building Blocks
  • Asymmetric Synthesis