cis-1,2-Diaminocyclohexane
Description References- Product Name
- cis-1,2-Diaminocyclohexane
- CAS No.
- 1436-59-5
- Chemical Name
- cis-1,2-Diaminocyclohexane
- Synonyms
- (2-aminocyclohexyl)amine;cis-1,2-Cyclohexandiamine;CIS-1,2-CYCLOHEXANEDIAMINE;CIS-1,2-DIAMINOCYCLOHEXANE;meso-1,2-Cyclohexanediamine;cis-Cyclohexane-1,2-diamine;1,2-DIAMINOCYCLOHEXANE, cis;1,2-Cyclohexanediamine, cis-;(R)(S)-1,2-Diaminocyclohexane;(1R,2S)-1,2-Cyclohexanediamine
- CBNumber
- CB9412187
- Molecular Formula
- C6H14N2
- Formula Weight
- 114.19
- MOL File
- 1436-59-5.mol
cis-1,2-Diaminocyclohexane Property
- Melting point:
- 8°C
- Boiling point:
- 92-93 °C/18 mmHg (lit.)
- Density
- 0.952 g/mL at 25 °C (lit.)
- vapor pressure
- 0.4 mm Hg ( 20 °C)
- refractive index
- n20/D 1.493(lit.)
- Flash point:
- 161 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Water Solubility
- Completely miscible in water
- form
- Low Melting Solid
- pka
- 9.93(at 20℃)
- color
- Brown
- InChIKey
- SSJXIUAHEKJCMH-OLQVQODUSA-N
- CAS DataBase Reference
- 1436-59-5(CAS DataBase Reference)
- NIST Chemistry Reference
- cis-1,2-Cyclohexanediamine(1436-59-5)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2735 8/PG 2
- WGK Germany
- 3
- F
- 10-34
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29213000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C1463
- Product name
- cis-1,2-Cyclohexanediamine
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $72
- Updated
- 2024/03/01
- Product number
- C1463
- Product name
- cis-1,2-Cyclohexanediamine
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $210
- Updated
- 2024/03/01
- Product number
- D416224
- Product name
- cis-1,2-Diaminocyclohexane
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D416224
- Product name
- cis-1,2-Diaminocyclohexane
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CHM0014089
- Product name
- CIS-1, 2-DIAMINO CYCLOHEXANE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $686.54
- Updated
- 2021/12/16
cis-1,2-Diaminocyclohexane Chemical Properties,Usage,Production
Description
cis-1, 2-Diaminocyclohexane is a cyclohexane derivative. It can be used for the synthesis of platinum complexes with high antitumor activity. It can also be used for the preparation of multidentate ligands for uranyl and transition metal complexation. Moreover, it can also be used as the base for the manufacturing of titanium salalen catalyst. Its derivative also has the potential to be manufactured into a potent factor Xa inhibitor.
References
Khokhar, Abdul R., et al. "Chemical and Biological Studies on a Series of Novel (trans-(1R,2R)-, trans-(1S,2S)-, and cis-1,2-Diaminocyclohexane)platinum(IV) Carboxylate Complexes." Journal of Medicinal Chemistry 40.1(1997):112.
Mauldin, S. K., et al. "High-performance liquid chromatographic separation of platinum complexes containing the cis-1,2-diaminocyclohexane carrier ligand. " Analytical Biochemistry157.1 (1986):129-43.
Berkessel, A, et al. "Titanium salalen catalysts based on cis-1,2-diaminocyclohexane: enantioselective epoxidation of terminal non-conjugated olefins with H2O2. " Angewandte Chemie 52.32(2013):8467-71.
Yoshikawa, K, et al. "Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties. " Bioorganic & Medicinal Chemistry 17.24(2009):8221.
http://www.sigmaaldrich.com/catalog/product/aldrich/307467?lang=en®ion=US
Chemical Properties
Clear colorless liquid
Uses
cis-1,2-Diaminocyclohexane was used in the synthesis of platinum complexes that have high antitumor activity.It was also used in the synthesis of multidentate ligands for uranyl and transition metal complexation.
General Description
cis-1,2-Diaminocyclohexane perturbed the spectrum of free pyrroloquinoline quinone (PQQ), a covalently linked form of which is the carbonyl cofactor of lysyl oxidase and also induced similar changes in the spectrum of lysyl oxidase.
Purification Methods
Dry the diamine over solid KOH and distil it in a vacuum. It is a strong base, keep away from CO2, store in the dark under N2. [Beilstein 13 IV 1.]
cis-1,2-Diaminocyclohexane Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from cis-1,2-Diaminocyclohexane manufacturers
- Product
- (±)-cis-1,2-Diaminocyclohexane 1436-59-5
- Price
- US $20.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 tons
- Release date
- 2022-09-16
- Product
- cis-1,2-Diaminocyclohexane 1436-59-5
- Price
- US $31.00-274.00/g
- Min. Order
- 5g
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-12-11
- Product
- cis-1,2-Diaminocyclohexane 1436-59-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11