4-(Aminomethyl)tetrahydro-2H-pyran

Product Name: 4-(Aminomethyl)tetrahydro-2H-pyran
CAS No.: 130290-79-8
Chemical Name: 4-(Aminomethyl)tetrahydro-2H-pyran
Synonyms: oxan-4-ylmethanamine;ASINEX-REAG BAS 07731534;4-Aminotetrahydro-4H-pyran;4-AMINOMETHYLTETRAHYDROPYRAN;4-AMINOMETYYLTETRAHYDROPYRAN;4-(Aminomethyl)tetrahydro...;4-(Aminomethyl) tetrahydro-2;4-(Aminomethyl)tetrahydropyrane;4-AMinoMethyltetrahydropyran 1GR;4-AMinoMethyltetrahydropyran 5GR
CBNumber: CB9418437
Molecular Formula: C6H13NO
Formula Weight: 115.17
MOL File: 130290-79-8.mol

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4-(Aminomethyl)tetrahydro-2H-pyran Property

Boiling point:: 75 °C
Density: 1.02
refractive index: 1.4630-1.4670
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: clear liquid
pka: 10.01±0.29(Predicted)
color: Colorless to Light yellow
InChI: InChI=1S/C6H13NO/c7-5-6-1-3-8-4-2-6/h6H,1-5,7H2
InChIKey: IPBPLHNLRKRLPJ-UHFFFAOYSA-N
SMILES: C1OCCC(CN)C1
CAS DataBase Reference: 130290-79-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C,Xn
Risk Statements: 34-41-37/38-22
Safety Statements: 26-36/37/39-45-39
RIDADR: 2735
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2550
Product name: 4-Aminomethyltetrahydropyran
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $74
Updated: 2025/07/31

TCI Chemical

Product number: A2550
Product name: 4-Aminomethyltetrahydropyran
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $236
Updated: 2025/07/31

TRC

Product number: A615885
Product name: 4-Aminomethyltetrahydropyran
Packaging: 2.5g
Price: $220
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0025391
Product name: 4-AMINOMETHYLTETRAHYDROPYRAN
Purity: 95.00%
Packaging: 1G
Price: $605.22
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0025391
Product name: 4-AMINOMETHYLTETRAHYDROPYRAN
Purity: 95.00%
Packaging: 5G
Price: $854.7
Updated: 2021/12/16

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4-(Aminomethyl)tetrahydro-2H-pyran Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

4-Aminomethyltetrahydropyran is a reagent that is used in core modification in discovery of CC214-2 which is an orally available , selective inhibitor of mTOR kinase. 4-Aminomethyltetrahydropyran is also used as a reagent in the development of pyrazoloquinolines as PDE10A inhibitor for the treatment of schizophrenia.

Synthesis

4295-99-2

130290-79-8

Example 43 (Synthesis of 4-aminomethyltetrahydropyran): In a 200 mL stainless steel autoclave equipped with a stirring device, a thermometer, and a manometer, 10.0 g (90.0 mmol) of 4-cyanotetrahydropyran, 50.0 g of a 22% (w/w) ammonia-methanol solution, and 2.0 g (17.0 mmol as nickel atoms) of activated Raney nickel ( provided by Nikki Chemical Co., Ltd; nickel sponge N154D). The reaction was stirred under hydrogen atmosphere at 45 to 55 °C and 0.51 to 0.61 MPa pressure for 17 hours. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was washed with 30 mL of methanol. The filtrate and washings were combined, concentrated under reduced pressure and then distilled under reduced pressure at 73-74 °C and 2.67 kPa to give 7.94 g (76.6% isolated yield) of 4-aminomethyltetrahydropyran as a colorless liquid. Its physical properties were as follows: 1H-NMR (DMSO-d6, δ (ppm)): 1.02-1.16 (2H, m), 1.10-1.50 (2H, brs), 1.34-1.45 (1H, m), 1.56-1.61 (2H, m), 2.39 (2H, d, J = 6.3 Hz), 3.20-3.29 (2H, m ), 3.81-3.86 (2H, m); CI-MS (m/e): 116 (M+1), 99. Example 45 (Synthesis of 4-aminomethyltetrahydropyran): in a 200 mL stainless steel autoclave equipped with a stirring device, a thermometer, and a manometer, 10.0 g (90.0 mmol) of 4-cyanotetrahydropyran, 100 mL of a 22% (w/w) ammonia-methanol solution, and 2.0 g (17.0 mmol as nickel atoms) of activated Raney nickel ( provided by Nikki Chemical Co., Ltd; nickel sponge N154D). The reaction was stirred under hydrogen atmosphere at 50 to 60 °C and 0.51 to 0.61 MPa pressure for 5 hours. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was washed with 30 mL of methanol. The filtrate and washings were combined and analyzed by gas chromatography (internal standard method) to confirm the formation of 8.84 g (85.3% reaction yield) of 4-aminomethyltetrahydropyran and no by-product bis(4-tetrahydropyranosylmethyl)amine was detected.

References

[1] Patent: EP1671937, 2006, A1. Location in patent: Page/Page column 16-17
[2] Patent: EP1671937, 2006, A1. Location in patent: Page/Page column 17
[3] Justus Liebigs Annalen der Chemie, 1938, vol. 535, p. 37,45
[4] Patent: US6372778, 2002, B1. Location in patent: Example 80
[5] Patent: US2006/63804, 2006, A1. Location in patent: Page/Page column 13

4-(Aminomethyl)tetrahydro-2H-pyran Preparation Products And Raw materials

Raw materials

Hexane Ammonium hydroxide Ethanol Potassium hydroxide Acetone Ethyl propionate Potassium carbonate Sodium 2,2'-Dichlorodiethyl ether Tetrahydrofuran Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Diethyl malonate Dimethyl sulfate

Preparation Products

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4-(Aminomethyl)tetrahydro-2H-pyran Suppliers

Americas 1 Austria 1 Belgium 3 Canada 3 CHINA 233 Europe 1 France 3 Germany 9 India 14 Japan 2 Russia 2 Singapore 1 The Netherlands 1 United Kingdom 13 United States 46 Global 333

CHEMOS GmbH & Co. KG

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ChemPur GmbH

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ACTIVATE SCIENTIFIC GmbH

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Minakem Leuna GmbH

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SYNTHON Chemicals GmbH & Co. KG

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ABCR GmbH & CO. KG

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PARAGOS

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Service Chemical Inc.

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View Lastest Price from 4-(Aminomethyl)tetrahydro-2H-pyran manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-(Aminomethyl)tetrahydro-2H-pyran 130290-79-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-11

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-(Aminomethyl)tetrahydro-2H-pyran 130290-79-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Henan Aochuang Chemical Co.,Ltd.

Product: 4-(Aminomethyl)tetrahydro-2H-pyran 130290-79-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

130290-79-8, 4-(Aminomethyl)tetrahydro-2H-pyranRelated Search:

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C-(TETRAHYDRO-PYRAN-4-YL)-METHYLAMINE

ASINEX-REAG BAS 07731534

1-TETRAHYDRO-2H-PYRAN-4-YLMETHANAMINE

4-AMINOMETHYLTETRAHYDROPYRAN

4-(Aminomethyl)tetrahydro-2H-pyran 98%

(TETRAHYDROPYRAN-4-YL)METHYLAMINE

(TETRAHYDRO-2H-PYRAN-4-YL) METHANAMINE

(TETRAHYDRO-2H-PYRAN-4-YLMETHYL)AMINE

4-(Aminomethyl)tetrahydropyrane

4-AMINOMETYYLTETRAHYDROPYRAN

4-(Aminomethyl)tetrahydro-2H-pyran

4-Aminomethyltetrahydropyran ,97%

4-Aminomethyltetrahydropyran1-Tetrahydro-2H-pyran-4-ylmethanamine

1-tetrahydro-2H-pyran-4-ylmethanamine hydrochloride

4-(Aminomethyl)tetrahydro...

(tetrahydro-2H-pyran-4-ylmethyl)amine(SALTDATA: HCl)

4-AMinoMethyltetrahydropyran 1GR

4-AMinoMethyltetrahydropyran 250MG

4-AMinoMethyltetrahydropyran 5GR

oxan-4-ylmethanamine

(Aminomethyl)tetrahydro-2H-pyran

1-(Tetrahydro-2H-pyran-4-yl)methylamine

4-Aminotetrahydro-4H-pyran

2H-Pyran-4-MethanaMine,tetrahydro-

(Tetrahydro-2H-pyran-4-yl)methylamine, 4-(Aminomethyl)oxane

4-Aminomethyltetrahydropyran &gt

4-(Aminomethyl)tetrahydro-2H-pyran ISO 9001：2015 REACH

4-(Aminomethyl) tetrahydro-2

4-Aminomethyltetrahydropyran, 98%

130290-79-8

Aminomethyl's

Pyrans, Piperidines & Piperazines

Amines

blocks

Heterocycles