ChemicalBook > CAS DataBase List > N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE

N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE

Product Name
N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
CAS No.
166815-96-9
Chemical Name
N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
Synonyms
166815-96-9;tert-Butyl 4-((tosyloxy);1-Boc-4-(tosyloxyMethyl)piperidine;N-Boc-4-(4-toluenesulfonyloxymethyl)piperidine;1-N-bOC-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE;1-Boc-4-(p-toluenesulfonyloxymethyl)piperidine,96%;1-Boc-4-(p-toluenesulfonyloxyMethyl)piperidine, 96%;N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl);N-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine;1-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine
CBNumber
CB9423172
Molecular Formula
C18H27NO5S
Formula Weight
369.48
MOL File
166815-96-9.mol
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N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE Property

Melting point:
74-76℃
Boiling point:
487.8±18.0 °C(Predicted)
Density 
1.174±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
-1.94±0.40(Predicted)
color 
White to Orange to Green
InChI
InChI=1S/C18H27NO5S/c1-14-5-7-16(8-6-14)25(21,22)23-13-15-9-11-19(12-10-15)17(20)24-18(2,3)4/h5-8,15H,9-13H2,1-4H3
InChIKey
DARTVAOOTJKHQW-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(COS(C2=CC=C(C)C=C2)(=O)=O)CC1
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4759
Product name
1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine
Purity
>98.0%(N)
Packaging
5g
Price
$50
Updated
2025/07/31
TCI Chemical
Product number
B4759
Product name
1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine
Purity
>98.0%(N)
Packaging
25g
Price
$239
Updated
2025/07/31
TRC
Product number
B809553
Product name
tert-Butyl4-((tosyloxy)methyl)piperidine-1-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
Chem-Impex
Product number
43467
Product name
1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine,≥98%(N)
Purity
≥98%(N)
Packaging
5G
Price
$48.54
Updated
2021/12/16
AK Scientific
Product number
J99644
Product name
N-Boc-4-(4-Toluenesulfonyloxymethyl)piperidine
Packaging
5g
Price
$49
Updated
2021/12/16
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N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE Chemical Properties,Usage,Production

Uses

tert-Butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate is a useful intermediate used in the preparation of biologically active molecules with pharmacological applications.

Synthesis

98-59-9

123855-51-6

166815-96-9

Example 1A Synthesis of tert-butyl 4-((tolylenesulfonyloxy)methyl)piperidine-1-carboxylate: N-BOC-4-piperidine methanol (10 g, 46.5 mmol) and triethylamine (5.64 g, 55.8 mmol) were dissolved in dichloromethane (100 mL) under nitrogen protection and cooled to 0°C. Subsequently, p-toluenesulfonyl chloride (9.73 g, 51.2 mmol) and 4-dimethylaminopyridine (1.13 g, 9.3 mmol) were slowly added to the solution. The reaction mixture was stirred at 17°C for 2 hours. After completion of the reaction, the reaction was quenched by the addition of water (100 mL). The aqueous layer was extracted with dichloromethane (100 mL x 2). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. Purification by column chromatography afforded 1-N-Boc-4-(4-methylbenzenesulfonyl oxymethyl)piperidine (17 g, 99% yield) as a white solid.LCMS (ESI) m/z: 370 (M + 1).

References

[1] Patent: US2017/29430, 2017, A1. Location in patent: Paragraph 0255
[2] Patent: CN105315267, 2016, A. Location in patent: Paragraph 0033; 0049
[3] Patent: WO2008/42282, 2008, A2. Location in patent: Page/Page column 107-108; 168-169; 210-211
[4] Patent: WO2012/168349, 2012, A1. Location in patent: Page/Page column 37
[5] Patent: US2013/34504, 2013, A1. Location in patent: Paragraph 0147; 0148; 0149

N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE Suppliers

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View Lastest Price from N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE manufacturers

Anhui Dexinjia Biopharm Co., Ltd
Product
N-tert-Butoxycarbonyl -4-(4-toluenesulfonyloxymethyl) 166815-96-9
Price
US $500.00/kg
Min. Order
0.10000000149011612kg
Purity
NLT 98%
Supply Ability
2MT per month
Release date
2023-07-24
Yangzhou Qinyuan Pharmatech Co.,ltd
Product
N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE 166815-96-9
Price
US $10.00/g
Min. Order
10g
Purity
0.99
Supply Ability
1ton
Release date
2024-10-31
Career Henan Chemical Co
Product
N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE 166815-96-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-08

166815-96-9, N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINERelated Search:

1-N-BOC-3-FLUORO-ANILINE 6-tert-Butoxycarbonylamino-3-oxo-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester 1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE 1-Boc-4-methylpiperidine-4-carboxylic acid N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE 1-N-Boc-4-(Phenylamino)piperidine 1-BOC-4-METHANESULFONYLOXYMETHYL-PIPERIDINE P-TOLUENESULFONIC ACID (S)-2-METHYLBUTYL ESTER N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE

  • tert-butyl 4-{[(4-methylbenzenesulfonyl)oxy]methyl}piperidine-1-carboxylate
  • 4-[(4-methylphenyl)sulfonyloxymethyl]-1-piperidinecarboxylic acid tert-butyl ester
  • 4-[(4-methylphenyl)sulfonyloxymethyl]piperidine-1-carboxylic acid tert-butyl ester
  • tert-Butyl 4-((tosyloxy)
  • N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
  • 1-PIPERIDINECARBOXYLIC ACID, 4-[[[(4-METHYLPHENYL)SULFONYL]OXY]METHYL]-, 1,1-DIMETHYLETHYL ESTER
  • N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine95%
  • N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)
  • N-Boc-4-(4-toluenesulfonyloxymethyl)piperidine
  • 1-piperidinecarboxylic acid, 4-[[[(4-methylphenyl)sulfonyl
  • tert-butyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate
  • 1-N-bOC-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
  • 1-Boc-4-(p-toluenesulfonyloxyMethyl)piperidine, 96%
  • 1-Boc-4-(tosyloxyMethyl)piperidine
  • tert-Butyl 4-((tosyloxy)Methyl)piperidine-1-carboxylate
  • 4-[[(4-Tolylsulfonyl)oxy]methyl]piperidine-1-carboxylic acid tert-butyl ester
  • N-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine
  • N-tert-Butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine
  • 1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine
  • 166815-96-9
  • 1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine&gt
  • 1-N-BOC-4-(4-Methylbenzenesulfonyloxymethyl)piperidine
  • 1-Boc-4-(p-toluenesulfonyloxymethyl)piperidine,96%
  • 1-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine
  • N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidi...
  • 166815-96-9