ChemicalBook > CAS DataBase List > N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE

N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE

Product Name
N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
CAS No.
166815-96-9
Chemical Name
N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
Synonyms
166815-96-9;tert-Butyl 4-((tosyloxy);1-Boc-4-(tosyloxyMethyl)piperidine;N-Boc-4-(4-toluenesulfonyloxymethyl)piperidine;1-N-bOC-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE;1-Boc-4-(p-toluenesulfonyloxymethyl)piperidine,96%;1-Boc-4-(p-toluenesulfonyloxyMethyl)piperidine, 96%;N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl);N-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine;1-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine
CBNumber
CB9423172
Molecular Formula
C18H27NO5S
Formula Weight
369.48
MOL File
166815-96-9.mol
More
Less

N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE Property

Melting point:
74-76℃
Boiling point:
487.8±18.0 °C(Predicted)
Density 
1.174±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
-1.94±0.40(Predicted)
color 
White to Orange to Green
InChI
InChI=1S/C18H27NO5S/c1-14-5-7-16(8-6-14)25(21,22)23-13-15-9-11-19(12-10-15)17(20)24-18(2,3)4/h5-8,15H,9-13H2,1-4H3
InChIKey
DARTVAOOTJKHQW-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(COS(C2=CC=C(C)C=C2)(=O)=O)CC1
More
Less

Safety

HazardClass 
IRRITANT
HS Code 
2933399990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
B4759
Product name
1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine
Purity
>98.0%(N)
Packaging
5g
Price
$50
Updated
2025/07/31
TCI Chemical
Product number
B4759
Product name
1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine
Purity
>98.0%(N)
Packaging
25g
Price
$239
Updated
2025/07/31
TRC
Product number
B809553
Product name
tert-Butyl4-((tosyloxy)methyl)piperidine-1-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
Chem-Impex
Product number
43467
Product name
1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine,≥98%(N)
Purity
≥98%(N)
Packaging
5G
Price
$48.54
Updated
2021/12/16
AK Scientific
Product number
J99644
Product name
N-Boc-4-(4-Toluenesulfonyloxymethyl)piperidine
Packaging
5g
Price
$49
Updated
2021/12/16
More
Less

N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE Chemical Properties,Usage,Production

Uses

tert-Butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate is a useful intermediate used in the preparation of biologically active molecules with pharmacological applications.

Synthesis

98-59-9

123855-51-6

166815-96-9

Example 1A Synthesis of tert-butyl 4-((tolylenesulfonyloxy)methyl)piperidine-1-carboxylate: N-BOC-4-piperidine methanol (10 g, 46.5 mmol) and triethylamine (5.64 g, 55.8 mmol) were dissolved in dichloromethane (100 mL) under nitrogen protection and cooled to 0°C. Subsequently, p-toluenesulfonyl chloride (9.73 g, 51.2 mmol) and 4-dimethylaminopyridine (1.13 g, 9.3 mmol) were slowly added to the solution. The reaction mixture was stirred at 17°C for 2 hours. After completion of the reaction, the reaction was quenched by the addition of water (100 mL). The aqueous layer was extracted with dichloromethane (100 mL x 2). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. Purification by column chromatography afforded 1-N-Boc-4-(4-methylbenzenesulfonyl oxymethyl)piperidine (17 g, 99% yield) as a white solid.LCMS (ESI) m/z: 370 (M + 1).

References

[1] Patent: US2017/29430, 2017, A1. Location in patent: Paragraph 0255
[2] Patent: CN105315267, 2016, A. Location in patent: Paragraph 0033; 0049
[3] Patent: WO2008/42282, 2008, A2. Location in patent: Page/Page column 107-108; 168-169; 210-211
[4] Patent: WO2012/168349, 2012, A1. Location in patent: Page/Page column 37
[5] Patent: US2013/34504, 2013, A1. Location in patent: Paragraph 0147; 0148; 0149

N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE Suppliers

Americas 1 China 134 Europe 1 Germany 2 India 5 Japan 1 Switzerland 1 Ukraine 2 United Kingdom 2 United States 12 Global 161
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
More
Less

View Lastest Price from N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE manufacturers

Anhui Dexinjia Biopharm Co., Ltd
Product
N-tert-Butoxycarbonyl -4-(4-toluenesulfonyloxymethyl) 166815-96-9
Price
US $500.00/kg
Min. Order
0.10000000149011612kg
Purity
NLT 98%
Supply Ability
2MT per month
Release date
2023-07-24
Yangzhou Qinyuan Pharmatech Co.,ltd
Product
N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE 166815-96-9
Price
US $10.00/g
Min. Order
10g
Purity
0.99
Supply Ability
1ton
Release date
2024-10-31
Career Henan Chemical Co
Product
N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE 166815-96-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-08

166815-96-9, N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINERelated Search:

1-N-BOC-3-FLUORO-ANILINE 6-tert-Butoxycarbonylamino-3-oxo-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester 1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE 1-Boc-4-methylpiperidine-4-carboxylic acid N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE 1-N-Boc-4-(Phenylamino)piperidine 1-BOC-4-METHANESULFONYLOXYMETHYL-PIPERIDINE P-TOLUENESULFONIC ACID (S)-2-METHYLBUTYL ESTER N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE

  • tert-butyl 4-{[(4-methylbenzenesulfonyl)oxy]methyl}piperidine-1-carboxylate
  • 4-[(4-methylphenyl)sulfonyloxymethyl]-1-piperidinecarboxylic acid tert-butyl ester
  • 4-[(4-methylphenyl)sulfonyloxymethyl]piperidine-1-carboxylic acid tert-butyl ester
  • tert-Butyl 4-((tosyloxy)
  • N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
  • 1-PIPERIDINECARBOXYLIC ACID, 4-[[[(4-METHYLPHENYL)SULFONYL]OXY]METHYL]-, 1,1-DIMETHYLETHYL ESTER
  • N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine95%
  • N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)
  • N-Boc-4-(4-toluenesulfonyloxymethyl)piperidine
  • 1-piperidinecarboxylic acid, 4-[[[(4-methylphenyl)sulfonyl
  • tert-butyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate
  • 1-N-bOC-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
  • 1-Boc-4-(p-toluenesulfonyloxyMethyl)piperidine, 96%
  • 1-Boc-4-(tosyloxyMethyl)piperidine
  • tert-Butyl 4-((tosyloxy)Methyl)piperidine-1-carboxylate
  • 4-[[(4-Tolylsulfonyl)oxy]methyl]piperidine-1-carboxylic acid tert-butyl ester
  • N-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine
  • N-tert-Butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine
  • 1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine
  • 166815-96-9
  • 1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine&gt
  • 1-N-BOC-4-(4-Methylbenzenesulfonyloxymethyl)piperidine
  • 1-Boc-4-(p-toluenesulfonyloxymethyl)piperidine,96%
  • 1-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine
  • N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidi...
  • 166815-96-9