Oxytetracycline dihydrate

Description Synthesis

Product Name: Oxytetracycline dihydrate
CAS No.: 6153-64-6
Chemical Name: Oxytetracycline dihydrate
Synonyms: trramycin;OXYCYCLINE;DOXYCYCLINE USP 23;OXYTETRACYCLINEFEED;DOXYCYCLINE HYCHLATE;Terramycin Dihydrate;Doxycycline dihydrate;OXYTETRACYCLINE HCL BP;Oxytetracycline (200 mg);OXYTETRACYCLINE DIHYDRATE
CBNumber: CB9426658
Molecular Formula: C22H26N2O10
Formula Weight: 478.45
MOL File: 6153-64-6.mol

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Oxytetracycline dihydrate Property

Melting point:: 181-182 °C
alpha: -216 º (c=1,0.1 M HCl)
storage temp.: Sealed in dry,Room Temperature
solubility: 1 M HCl: 0.1 M yellow to yellow-orange, clear
form: crystalline
color: yellow
Water Solubility: slightly soluble
CAS DataBase Reference: 6153-64-6(CAS DataBase Reference)
EPA Substance Registry System: Oxytetracycline dihydrate (6153-64-6)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 63-36-36/37/38
Safety Statements: 22-24/25-36/37/39-26-36
WGK Germany: 3
HS Code: 29413000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O4636
Product name: Oxytetracycline dihydrate
Purity: BioXtra
Packaging: 10g
Price: $76.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1491004
Product name: Oxytetracycline
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1537
Product name: Oxytetracycline
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1g
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: O4636
Product name: Oxytetracycline dihydrate
Purity: BioXtra
Packaging: 50g
Price: $124
Updated: 2024/03/01

TRC

Product number: O877501
Product name: Oxytetracycline dihydrate
Packaging: 1g
Price: $120
Updated: 2021/12/16

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Oxytetracycline dihydrate Chemical Properties,Usage,Production

Description

Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. It's a prescription antibiotic that interferes with bacteria's ability to produce essential proteins.

Synthesis

Oxytetracycline dihydrate is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.

Chemical Properties

yellow crystalline powder

Uses

Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial.

Uses

antihypertensive

brand name

Terramycin (Pfizer).

General Description

Oxytetracycline was found in the culture broth of Streptomyces rimosus by Pfizer in 1950 and named terramycin. It is closely related to chlortetracycline (aureomycin), and its structure was elucidated in 1952. Oxytetracycline has had wide clinical use as a substitute for chlortetracycline, even after the introduction of tetracycline. Oxytetracycline is administered orally, topically, and parenterally.

Purification Methods

Terramycin crystallises (as dihydrate) from water or aqueous EtOH and is soluble in MeOH, EtOH, Me2CO and H2O (0.25mg/mL at 25o ) but insoluble in Et2O and pet ether. It is amphoteric, and an aqueous solution has pH 2.0-5.0. It has max at 247, 275 and 353nm in 0.1 M phosphate (pH 4.5). [Finlay et al. Science 111 85 1951.] The hydrochloride, [2058-46-0] M 496.9 [Beilstein 14 IV 2630], crystallises from MeOH in needles and from H2O at 50o it forms plates. Terramycin has also been purified via the hydrochloride by dissolving it in H2O, adjusting to pH 6, and the solid is filtered off after 1hour. The crystals of the dihydrate are dried to constant weight in vacuum/CaCl2/25o. Drying at 60o in vacuo gives the anhydrous base m 184.5-185.5o (sintering at 180o). The dihydrate has m 181-182o. Its optical rotation in MeOH decreases from [] D 25 +26o (c 0.5%) to [] D 25 +11.3o after standing for 16hours. It forms a sodium salt and a CaCl2 complex. [Regna et al. J Am Chem Soc 73 4211 1951, Beilstein 14 IV 2633.]

Oxytetracycline dihydrate Preparation Products And Raw materials

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View Lastest Price from Oxytetracycline dihydrate manufacturers

Watson Biotechnology Co.,Ltd

Product: Oxytetracycline Dihydrate 6153-64-6
Price: US $20.00-12.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2024-07-23

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Oxytetracycline Dihydrate 6153-64-6
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-25

Apeloa production Co.,Limited

Product: Oxytetracycline Dihydrate 6153-64-6
Price: US $1.00/g
Min. Order: 1g
Purity: 0.98
Supply Ability: 1000
Release date: 2024-07-18

6153-64-6, Oxytetracycline dihydrateRelated Search:

4-Dimethylaminopyridine 4-Dimethylaminobenzoic acid 3-Dimethylaminopropylamine 4-Dimethylaminobenzaldehyde 1,4-Dioxane Selenium dioxide Oxytetracycline DL-2-AMINO-3-METHYL-1-BUTANOL 1-HEPTEN-3-OL 2,4-DIETHYL-1,5-PENTANEDIOL O-CYMENE 2'-Hydroxypropiophenone Isononylamine 1,2,5-PENTANETRIOL 1,4-PENTANEDIOL 3-PENTEN-2-OL FOROXYMITHINE 2-PROPYL-2-HEPTENAL

OXYTETRACYCLINE DIHYDRATE

4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide dihydrate

DOXYCYCLINE USP 23

OXYCYCLINE

DOXYCYCLINE HYCHLATE

DOXYCYCLINE HCL ( VETERINARY)

OXYTETRACYCLINE HCL BP

DOXYCYCLINE HYDRATE BP98 USP23

(4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide,hydrate (1:2)

Oxytetracycline dihydrate BioXtra

trramycin

OXYTETRACYCLINE DIHYDRATE SIGMAULTRA

OxytetracyclineHcl2058-46-0,

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, dihydrate, (4S,4aR,5S,5aR,6S,12aS)-

OXYTETRACYCLINEFEED

OXYTETRACYCLINE DIHYDRATE, INJECTABLE GRADE

OXYTETRACYCLINE DIHYDRATE, ORAL GRADE

Oxytetracycline dihydrate,95%

[4S-(4α,4aα,5α,5aα,6β,12aα]-

Oxytetracycline, Dihydrate, USP

Oxytetracycline/doxycycline

Oxytetracycline dihydrate Solution, 100ppm

Oxytetracycline (200 mg)J0C084913ug/mg(ai)

Oxytetracycline (200 mg)

Doxycycline dihydrate

Terramycin Dihydrate

(4S,4aR,5S,5aR,6S,12aS)-4-(Dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide dihydrate

Oxytetracycline dihydrate injections USP/EP/BP

Oxytetracycline dihydrate USP/EP/BP

OXYTETRACYCLINE DIHYDRATE INJECTABLE

Oxytetracycline 2-hydrate

Oxytetracycline dihydrateQ: What is Oxytetracycline dihydrate Q: What is the CAS Number of Oxytetracycline dihydrate Q: What is the storage condition of Oxytetracycline dihydrate

Oxytetracycline dihydrate API

Oxytetracycline injection grade

Oxytetracycline Dihydrate (OTC.2H2O) extrapure, 98%

Oxytetracycline (1491004)

Rabbit Anti-Oxytetracycline antibody

C15819990 OxytetracyclinEdihydrate

Oxytetracycline Dihydrate, 10 mM in DMSO

6153-64-6

C22H28N2O11

C22H24N2O92H2O

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