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Diethyl L-malate

Product Name
Diethyl L-malate
CAS No.
691-84-9
Chemical Name
Diethyl L-malate
Synonyms
DIETHYL L-(-)-MALATE;(S)-diethyl 2-hydroxysuccinate;DIETHYL L-MALATE;(S)-(-)-DIETHYLMALATE;Malicaciddiethylester;DiethylL-(-)-Malate>Malic Acid Impurity 14;L-MALIC ACID DIETHYL ESTER;691-84-9 Diethyl L-malate;L-Matic acid dimethyl ester
CBNumber
CB9428692
Molecular Formula
C8H14O5
Formula Weight
190.19
MOL File
691-84-9.mol
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Diethyl L-malate Property

alpha 
-10.18°
Boiling point:
253℃
Density 
1.13
refractive index 
1.4330 to 1.4370
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
12.35±0.20(Predicted)
form 
Oil
color 
Colourless
Specific Gravity
1.1280 (20/4℃)
Dielectric constant
9.5（20℃）
CAS DataBase Reference
691-84-9(CAS DataBase Reference)
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Safety

HS Code 
29181990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
M1348
Product name
Diethyl L-(-)-Malate
Purity
>97.0%(GC)
Packaging
5g
Price
$26
Updated
2025/07/31
TCI Chemical
Product number
M1348
Product name
Diethyl L-(-)-Malate
Purity
>97.0%(GC)
Packaging
25g
Price
$100
Updated
2025/07/31
TRC
Product number
D444510
Product name
Diethyl L-(-)-Malate
Packaging
10g
Price
$100
Updated
2021/12/16
AK Scientific
Product number
J54724
Product name
Diethyl L-(-)-Malate
Packaging
5g
Price
$20
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD60147
Product name
Diethyl L-(-)-Malate
Packaging
25g
Price
$56
Updated
2021/12/16
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Diethyl L-malate Chemical Properties,Usage,Production

Uses

Diethyl L-(-)-Malate is a reagent in the stereoselective synthesis of crucigasterin A and antitumor activity of crucigasterin A, B, and D.

Definition

ChEBI: Diethyl L-malate is a 3-hydroxy carboxylic acid.

Synthesis

64-17-5

97-67-6

691-84-9

Step 1 (Synthesis of compound 34-2) (0217) L-malic acid (80 g, 600 mmol) was dissolved in anhydrous ethanol (500 mL) and thionyl chloride (100 mL, 1.5 mol) was added slowly and dropwise at 0 °C. The reaction mixture was stirred at 0 °C for 20 min, then warmed to room temperature and continued to stir overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the residue was extracted with ethyl acetate (1000 mL x 3). The organic phases were combined and washed sequentially with water (500 mL×2) and saturated sodium chloride solution (500 mL×2), and the organic layer was dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography (eluent system: petroleum ether/ethyl acetate = 20:1) to afford diethyl (S)-2-hydroxysuccinate (113 g, 99% yield). (0218) 1H NMR (400 MHz, CDCl3) δ: 4.47 (q, J = 4.8 Hz, 1H), 4.26 (dq, J = 2.4, 7.2 Hz, 2H), 4.16 (q, J = 7.2 Hz, 2H), 3.28 (d, J = 4.8 Hz, 1H), 2.72-2.89 (m, 2H), 1.20- 1.34 (m, 6H).

References

[1] Patent: US2017/197986, 2017, A1. Location in patent: Paragraph 0216; 0217; 0218
[2] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 9, p. 969 - 974
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2015, vol. 53, # 22, p. 2586 - 2597
[4] European Journal of Organic Chemistry, 2012, # 5, p. 995 - 1002
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 18, p. 5192 - 5194

Diethyl L-malate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Diethyl L-malate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Diethyl L-malate 691-84-9
Price
US $120.00-1200.00/g
Min. Order
1g
Purity
98%min
Supply Ability
200tons
Release date
2025-08-19
Qingdao RENAS Polymer Material Co., Ltd.
Product
Diethyl L-malate 691-84-9
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-08-26
Career Henan Chemical Co
Product
L-Matic acid dimethyl ester 691-84-9
Price
US $30.00/KG
Min. Order
25KG
Purity
98%
Supply Ability
100kg
Release date
2018-08-01

691-84-9, Diethyl L-malateRelated Search:

CITRIC ACID TRI-N-PROPYL ESTER CITRIC ACID TRIALLYL ESTER Tributyl citrate Triethyl citrate STEARYL CITRATE Diisopropyl D-tartrate tris(2-ethylhexyl) 2-(acetyloxy)propane-1,2,3-tricarboxylate Triethyl acetyl citrate Acetyl tributyl citrate (-)-DIBUTYL-D-TARTRATE (2S,3S)(-)-Dihydroxybutane-1,4-dioic acid diethyl ester TRIS(2-ETHYLHEXYL)CITRATE DIETHYL DL-MALATE,Diethyl DL-Malate, 99% (GC) DIETHYL DL-MALATE DIETHYL D-(+)-MALATE TRI-N-AMYL CITRATE (-)-DI-TERT-BUTYL D-TARTRATE (2S,3S)-(+)-DIETHYL 2,3-O-BENZYLIDENETARTRATE

  • (2S)-2-Hydroxybutanedioic acid diethyl ester
  • (S)-2-Hydroxybutanedioic acid diethyl ester
  • L-(-)-Apple Acid Diethyl Ester L-(-)-Malic Acid Diethyl Ester
  • (S)-diethyl 2-hydroxysuccinate
  • (S)-(-)-DIETHYL HYDROXYSUCCINATE
  • (S)-(-)-DIETHYLMALATE
  • (S)-2-HYDROXY-SUCCINIC ACID DIETHYL ESTER
  • DIETHYL L-(-)-MALATE
  • DIETHYL L-MALATE
  • L-(-)-MALIC ACID DIETHYL ESTER
  • L-MALIC ACID DIETHYL ESTER
  • L-(-)-APPLE ACID DIETHYL ESTER
  • Malicaciddiethylester
  • L-Matic acid dimethyl ester
  • DiethylL-(-)-Malate&gt
  • Malic Acid Impurity 14
  • Butanedioic acid, 2-hydroxy-, 1,4-diethyl ester, (2S)-
  • 691-84-9 Diethyl L-malate
  • 691-84-9
  • ALCOHOL
  • Esters (Chiral)
  • Chiral Building Blocks
  • Synthetic Organic Chemistry
  • Chiral Building Blocks
  • Esters (Chiral)