(TRIMETHYLSILYL)DIAZOMETHANE

Product Name: (TRIMETHYLSILYL)DIAZOMETHANE
CAS No.: 18107-18-1
Chemical Name: (TRIMETHYLSILYL)DIAZOMETHANE
Synonyms: TMSCHN2;TMS-DIAZOMETHANE;(DIAZOMETHYL)TRIMETHYLSILANE;(trimethylsilyl)diazomethanesolution;2.0 M in hexanes;ACROS Organics™TriMethylsilyl)diazoMethan;iazomethyl(trimethyl)silane;(TRIMETHYLSILYL)DIAZOMETHANE;Diazo(trimethylsilyl)methane
CBNumber: CB9432840
Molecular Formula: C4H10N2Si
Formula Weight: 114.22
MOL File: 18107-18-1.mol

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(TRIMETHYLSILYL)DIAZOMETHANE Property

Boiling point:: 96 °C
Density: 0.773 g/mL at 25 °C
refractive index: 1.4362
Flash point:: −31 °F
storage temp.: Refrigerator
solubility: Sol most organic solvents; insol H2O.
form: Solution
color: White
Water Solubility: Immiscible with water. Miscible with organic solvents.
Sensitive: Moisture & Light Sensitive
BRN: 1902903
Stability:: Shock Sensitive
CAS DataBase Reference: 18107-18-1(CAS DataBase Reference)
EPA Substance Registry System: Silane, (diazomethyl)trimethyl- (18107-18-1)

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Safety

Hazard Codes: F+,Xn,N,F,T,T+
Risk Statements: 12-19-22-66-67-65-62-51/53-48/20-38-11-23-39/26-26-45
Safety Statements: 9-16-29-33-36/37-61-62-45-28-53
RIDADR: UN 1208 3/PG 2
WGK Germany: 3
F: 10
TSCA: Yes
HazardClass: 3
PackingGroup: II
HS Code: 29270000
Hazardous Substances Data: 18107-18-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H304May be fatal if swallowed and enters airways

H315Causes skin irritation

H330Fatal if inhaled

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H350May cause cancer

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T1146
Product name: Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L)
Packaging: 10mL
Price: $105
Updated: 2024/03/01

TCI Chemical

Product number: T1146
Product name: Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L)
Packaging: 25mL
Price: $210
Updated: 2024/03/01

Alfa Aesar

Product number: H26744
Product name: (Trimethylsilyl)diazomethane, 2M in hexanes
Packaging: 25ml
Price: $204
Updated: 2021/12/16

Alfa Aesar

Product number: H26744
Product name: (Trimethylsilyl)diazomethane, 2M in hexanes
Packaging: 5ml
Price: $62.2
Updated: 2021/12/16

Sigma-Aldrich

Product number: 527254
Product name: (Trimethylsilyl)diazomethane solution
Purity: 2.0 M in diethyl ether
Packaging: 1l
Price: $3240
Updated: 2023/01/07

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(TRIMETHYLSILYL)DIAZOMETHANE Chemical Properties,Usage,Production

Chemical Properties

clear yellow solution

Physical properties

bp 96 °C/775 mmHg; nD/25 1.4362.2

Uses

Trimethylsilyldiazomethane is used as one-carbon homologation reagent; stable, safe substitute for diazomethane;participating in the synthesis reactions of insertion reactions;ketenylation reactions;preparation of homoallylic sulfides;pericyclic reactions;[C-N-N] 1,3-dipole for the preparation of azoles.

Uses

(Trimethylsilyl)diazomethane is used as an analyte in the determination of some phenolic organohalogens in human serum by GC-MS.

Uses

Reactant for preparation of: &bull Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity &bull Aigialomycin D analogues as protein kinase inhibitors for cancer treatment &bull Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction &bull Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates &bull Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity &bull Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach &bull Ent-kaurene derivatives as anti-inflammatory agents &bull Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint &bull Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors

Preparation

Trimethylsilyldiazomethane is prepared by the diazo-transfer reaction of trimethylsilylmethylmagnesium chloride with diphenyl phosphorazidate (DPPA) (eq 1).

General Description

(Trimethylsilyl)diazomethane is considered as a non-explosive substitute to diazomethane for the homologation of carbonyl derivatives, mainly ketones, via reactions such as Tiffeneau-Demjanov rearrangement.

(TRIMETHYLSILYL)DIAZOMETHANE Preparation Products And Raw materials

Raw materials

Hexane Sodium azide Acetone Diphenylphosphoryl azide Phenol Phosphorus oxychloride 1,2-Dibromoethane Tetrahydrofuran N,N-Dimethylaniline Chloromethyltrimethylsilane Diethyl ether Diphenyl chlorophosphate Magnesium

Preparation Products

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(TRIMETHYLSILYL)DIAZOMETHANE Suppliers

Belgium 3 China 189 Europe 1 France 1 Germany 4 India 7 Japan 4 Singapore 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 6 United States 24 Global 245

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9638
Advantage: 58

Shanghai Chemart Chemical Technology Co., Ltd.

Tel: 021-021-50400622 15618790390
Email: info@chemart.cn
Country: China
ProdList: 210
Advantage: 58

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Shanghai qiyan medicine technology co., ltd

Tel: 15021941186
Email: 3572772243@qq.com
Country: China
ProdList: 182
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
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Beijing Donghualituo Techonlogy Development Co.,Ltd.

Tel: 010-88425576
Fax: (+86)-10-88425546
Email: sales@dhltchem.com
Country: China
ProdList: 793
Advantage: 59

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
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Beijing dtftchem Technology Co., Ltd.

Tel: 010-60275820 13031183356
Fax: 010-60270825
Email: elainezt@sina.com
Country: China
ProdList: 1392
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View Lastest Price from (TRIMETHYLSILYL)DIAZOMETHANE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (Trimethylsilyl)diazomethane solution 2.0 M in diethyl ether 18107-18-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: (TRIMETHYLSILYL)DIAZOMETHANE 18107-18-1
Price: US $1.00/KG
Min. Order: 1G
Purity: 99%
Supply Ability: 100kg
Release date: 2018-08-12

18107-18-1, (TRIMETHYLSILYL)DIAZOMETHANERelated Search:

2-METHOXYPHENYLMAGNESIUM BROMIDE DIMETHYLALUMINUM CHLORIDE Chloromethane 4-ETHYLPHENYLMAGNESIUM BROMIDE 4-THIOANISOLEMAGNESIUM BROMIDE Tricyclohexyl phosphine 3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE (TRIMETHYLSILYL)METHYLLITHIUM P-TOLYLMAGNESIUM CHLORIDE 4-Methoxyphenylmagnesium bromide HEXANES Hexane TRIMETHYLSILANE Diazomethane (TRIMETHYLSILYL)DIAZOMETHANE

(trimethylsilyl)diazomethanesolution

TMS-DIAZOMETHANE

(TRIMETHYLSILYL)DIAZOMETHANE

(DIAZOMETHYL)TRIMETHYLSILANE

(Trimethylsilyl)diazomethane, ca. 2.0M solution in hexanes, tech.

Trimethylsilyldiazomethane,10%inhexane

TRIMETHYLSILYLDIAZOMETHANE, 1.0M IN METHYLENE CHLORIDE

（Trimethylsilyl)diazomethane solution 2M

(TRIMETHYLSILYL)DIAZOMETHANE, 2.0 M IN &

(Trimethylsilyl)diazomethane, 2M in hexanes

Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.60mol/L)

(TRIMETHYLSILYL)DIAZOMETHANE, 2.0 M IN D

(TRIMETHYLSILYL)DIAZOMETHANE, 2.0M SOLUT ION IN HEXANES

(TRIMETHYLSILYL)DIAZOMETHANE SOLUTION, ~2 M IN HEXANE

Trimethylsilyldiazomethane2.0MINdiethylester

(Trimethylsilyl)diazomethane, ca. 2.0M solution in hexanes, technical

(Trimethylsilyl)diazomethane, ca. 2.0M solution in hexanes

Diazo(trimethylsilyl)methane

Trimethyl(diazomethyl)silane

Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L)

(Trimethylsilyl)diazomethane,approx. 2M solution in diethyl ether

(Trimethylsilyl)diazomethane [2.0M solution in hexane]

Trimethylsilyldiazomethane, 2M in hexane

TMSCHN2

(Trimethylsilyl)diazomethane solution, 2M in hexanes

Diazomethyl(trimethyl)silane, 2 M solution in hexane

(Trimethylsilyl)diazomethane, 2.0 M solution in hexanes, J&KSeal

(Trimethylsilyl)diazomethane solution,(Diazomethyl)trimethylsilane

(Trimethylsilyl)diazomethane, approx. 2.0M solution in hexanes, AcroSeal, Technical

(Trimethylsilyl)diazomethane, approx. 2M solution in diethyl ether, AcroSeal

(ca. 10% in Hexane, ca. 0.6Mol/L)

TriMethylsilyldiazoMethane&nbsp

(TriMethylsilyl)diazoMethane, 2M solution in hexanes

(TriMethylsilyl)diazoMethane, technical, approx. 2.0M solution in hexanes, AcroSeal

TriMethylsilyl)diazoMethane solution 2.0 M in hexanes

TriMethylsilyl)diazoMethan

(TriMethylsilyl)diazoMethane, 0.6 M solution in hexane

Silane,(diazoMethyl)triMethyl-

(TriMethylsilyl)diazoMethane, 2.0 M solution in hexanes, SpcSeal

(TriMethylsilyl)diazoMethane, 2.0M solution in diethyl ether, SpcSeal

(TRIMETHYLSILYL)DIAZOMETHANE (2 M solution in Hexane)

(Trimethylsilyl)diazomethane solution 2.0 M in diethyl ether

(Trimethylsilyl)diazomethane (~0.6M in Hexanes)

iazomethyl(trimethyl)silane

CAS18107-18-1 diazomethyl(trimethyl)silane

(Trimethylsilyl)diazomethane, approx. 2M solution in diethyl ether, AcroSeal&trade

(Trimethylsilyl)diazomethane, technical, approx. 1.8 to 2.4M solution in hexanes, AcroSeal&trade

ACROS Organics&trade

ca. 30% in Hexane， ca. 2mol/L)

2.0 M in hexanes

(Trimethylsilyl)diazomethane 2. M in n-Hexane

18107-18-1

C4H10N2Si

CH33SiCHN2

Others

Synthetic Reagents

C-X Bond Formation (Non-Halogen)

Si-(C)4 Compounds