(TRIMETHYLSILYL)DIAZOMETHANE
- Product Name
- (TRIMETHYLSILYL)DIAZOMETHANE
- CAS No.
- 18107-18-1
- Chemical Name
- (TRIMETHYLSILYL)DIAZOMETHANE
- Synonyms
- TMSCHN2;TMS-DIAZOMETHANE;(DIAZOMETHYL)TRIMETHYLSILANE;(trimethylsilyl)diazomethanesolution;2.0 M in hexanes;ACROS Organics™TriMethylsilyl)diazoMethan;iazomethyl(trimethyl)silane;(TRIMETHYLSILYL)DIAZOMETHANE;Diazo(trimethylsilyl)methane
- CBNumber
- CB9432840
- Molecular Formula
- C4H10N2Si
- Formula Weight
- 114.22
- MOL File
- 18107-18-1.mol
(TRIMETHYLSILYL)DIAZOMETHANE Property
- Boiling point:
- 96 °C
- Density
- 0.773 g/mL at 25 °C
- refractive index
- 1.4362
- Flash point:
- −31 °F
- storage temp.
- Refrigerator
- solubility
- Sol most organic solvents; insol H2O.
- form
- Solution
- color
- White
- Water Solubility
- Immiscible with water. Miscible with organic solvents.
- Sensitive
- Moisture & Light Sensitive
- BRN
- 1902903
- Stability:
- Shock Sensitive
- CAS DataBase Reference
- 18107-18-1(CAS DataBase Reference)
- EPA Substance Registry System
- Silane, (diazomethyl)trimethyl- (18107-18-1)
Safety
- Hazard Codes
- F+,Xn,N,F,T,T+
- Risk Statements
- 12-19-22-66-67-65-62-51/53-48/20-38-11-23-39/26-26-45
- Safety Statements
- 9-16-29-33-36/37-61-62-45-28-53
- RIDADR
- UN 1208 3/PG 2
- WGK Germany
- 3
- F
- 10
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29270000
- Hazardous Substances Data
- 18107-18-1(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H304May be fatal if swallowed and enters airways
H315Causes skin irritation
H330Fatal if inhaled
H331Toxic if inhaled
H336May cause drowsiness or dizziness
H350May cause cancer
H361Suspected of damaging fertility or the unborn child
H370Causes damage to organs
H373May cause damage to organs through prolonged or repeated exposure
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T1146
- Product name
- Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L)
- Packaging
- 10mL
- Price
- $105
- Updated
- 2024/03/01
- Product number
- T1146
- Product name
- Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L)
- Packaging
- 25mL
- Price
- $210
- Updated
- 2024/03/01
- Product number
- H26744
- Product name
- (Trimethylsilyl)diazomethane, 2M in hexanes
- Packaging
- 25ml
- Price
- $204
- Updated
- 2021/12/16
- Product number
- H26744
- Product name
- (Trimethylsilyl)diazomethane, 2M in hexanes
- Packaging
- 5ml
- Price
- $62.2
- Updated
- 2021/12/16
- Product number
- 527254
- Product name
- (Trimethylsilyl)diazomethane solution
- Purity
- 2.0 M in diethyl ether
- Packaging
- 1l
- Price
- $3240
- Updated
- 2023/01/07
(TRIMETHYLSILYL)DIAZOMETHANE Chemical Properties,Usage,Production
Chemical Properties
clear yellow solution
Physical properties
bp 96 °C/775 mmHg; nD/25 1.4362.2
Uses
Trimethylsilyldiazomethane is used as one-carbon homologation reagent; stable, safe substitute for diazomethane;participating in the synthesis reactions of insertion reactions;ketenylation reactions;preparation of homoallylic sulfides;pericyclic reactions;[C-N-N] 1,3-dipole for the preparation of azoles.
Uses
(Trimethylsilyl)diazomethane is used as an analyte in the determination of some phenolic organohalogens in human serum by GC-MS.
Uses
Reactant for preparation of: &bull Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity &bull Aigialomycin D analogues as protein kinase inhibitors for cancer treatment &bull Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction &bull Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates &bull Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity &bull Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach &bull Ent-kaurene derivatives as anti-inflammatory agents &bull Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint &bull Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors
Preparation
Trimethylsilyldiazomethane is prepared by the diazo-transfer reaction of trimethylsilylmethylmagnesium chloride with diphenyl phosphorazidate (DPPA) (eq 1).
General Description
(Trimethylsilyl)diazomethane is considered as a non-explosive substitute to diazomethane for the homologation of carbonyl derivatives, mainly ketones, via reactions such as Tiffeneau-Demjanov rearrangement.
(TRIMETHYLSILYL)DIAZOMETHANE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (TRIMETHYLSILYL)DIAZOMETHANE manufacturers
- Product
- (Trimethylsilyl)diazomethane solution 2.0 M in diethyl ether 18107-18-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- (TRIMETHYLSILYL)DIAZOMETHANE 18107-18-1
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-08-12