ChemicalBook > CAS DataBase List > O-ACETYLSALICYLOYL CHLORIDE

O-ACETYLSALICYLOYL CHLORIDE

Product Name
O-ACETYLSALICYLOYL CHLORIDE
CAS No.
5538-51-2
Chemical Name
O-ACETYLSALICYLOYL CHLORIDE
Synonyms
SKL1282;ASPIRIN CHLORIDE;AKOS BBS-00003925;2-(Chlorocarbonyl);O-ACETYLSALICYLOYL C;o-Acetylsalicychloride;Acetylsalicoyl chloride;O-Acetoxybenzoylchloride;ACETYLSALICYLOYL CHLORIDE;2-ACETOXYBENZOYL CHLORIDE
CBNumber
CB9446371
Molecular Formula
C9H7ClO3
Formula Weight
198.6
MOL File
5538-51-2.mol
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O-ACETYLSALICYLOYL CHLORIDE Property

Melting point:
45-49 °C (lit.)
Boiling point:
107-110 °C/0.1 mmHg (lit.)
Density 
1.3219 (rough estimate)
refractive index 
n20/D 1.536(lit.)
Flash point:
>230 °F
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
powder to lump
color 
White to Orange to Green
Water Solubility 
Soluble in toluene. Reacts with water.
Sensitive 
Moisture Sensitive
BRN 
880372
Stability:
Moisture Sensitive
CAS DataBase Reference
5538-51-2(CAS DataBase Reference)
NIST Chemistry Reference
Acetylsalicyloyl chloride(5538-51-2)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
22-34-37-29
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
F 
3-10-21
Hazard Note 
Irritant/Corrosive/Moisture Sensitive
HazardClass 
8
PackingGroup 
II
HS Code 
29163900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
165190
Product name
O-Acetylsalicyloyl chloride
Purity
95%
Packaging
5g
Price
$51.4
Updated
2024/03/01
Sigma-Aldrich
Product number
165190
Product name
O-Acetylsalicyloyl chloride
Purity
95%
Packaging
25g
Price
$81.3
Updated
2024/03/01
TCI Chemical
Product number
A1917
Product name
O-Acetylsalicyloyl Chloride
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$38
Updated
2024/03/01
TCI Chemical
Product number
A1917
Product name
O-Acetylsalicyloyl Chloride
Purity
>97.0%(HPLC)(T)
Packaging
25g
Price
$120
Updated
2024/03/01
Alfa Aesar
Product number
L00919
Product name
O-Acetylsalicyloyl chloride, 97%
Packaging
25g
Price
$143
Updated
2024/03/01
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O-ACETYLSALICYLOYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

yellow to light orange chunks

Uses

O-Acetylsalicyloyl chloride was used in the synthesis of enantiomerically pure bidentate heteroorganic ligands built on simple achiral skeletons and containing an aziridine moiety. It was used in the general synthesis of acetoxybenzamides. It was used in the chemical synthesis of 2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)-aspirin conjugate via condensation reaction with 4-hydroxy-TEMPO. It was used as reagent in acylation of cyclobutenediones.

Purification Methods

Check first the IR to see if an OH frequency is present. If so, some free acid is present. Then reflux with acetyl chloride for 2-3hours and fractionate at high vacuum. The distillate should crystallise. It can be recrystallised from hexane or *C6H6 (m 60o, sintering at 52o). [Riegel & Wittcoff J Am Chem Soc 64 486 1942, Beilstein 10 H 86, 10 I 43, 10 II 55, 10 III 151, 10 IV 169.]

O-ACETYLSALICYLOYL CHLORIDE Preparation Products And Raw materials

Raw materials

Anhydrous benzene Acetylsalicylic acid

Preparation Products

4-Hydroxycoumarin BENORILATE p-Coumaric acid
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View Lastest Price from O-ACETYLSALICYLOYL CHLORIDE manufacturers

Hebei Guanlang Biotechnology Co,.LTD
Product
O-Acetylsalicyloyl Chloride 5538-51-2
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2023-04-19
Longyan Tianhua Biological Technology Co., Ltd
Product
O-Acetylsalicylryl chloride 5538-51-2
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99
Supply Ability
999
Release date
2020-11-09
Career Henan Chemical Co
Product
O-Acetylsalicylryl chloride 5538-51-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons
Release date
2020-02-14

5538-51-2, O-ACETYLSALICYLOYL CHLORIDERelated Search:

2-HYDROXYBENZOIC-3,4,5,6-D4 ACID 5-ACETYLSALICYLIC ACID salicylacyl glucuronide Acetylsalicylic Acid-d3 BENORILATE Carbasalate calcium 4-HYDROXYBENZOIC-2,3,5,6-D4 ACID Aspirin-acyl--D-glucuronide 4-Hydroxybenzoic-1,2,3,4,5,6-13C6 Acid 2-ACETOXYBENZOIC-3,4,5,6-D4 ACID METHYL 5-ACETYLSALICYLATE Salicylic Acid b-D-O-Glucuronide MR 897 Salicylic Acid-13C6 PU 122 2-[[2-[[2-(Acetyloxy)benzoyl]oxy]benzoyl]oxy]benzoic Acid 2-[[2-[(2-carboxyphenoxy)carbonyl]phenoxy]carbonyl]phenyl Ester 1-[bis(4-fluorophenyl)methyl]-2,2,3,3,5,5,6,6-octadeuterio-4-[3-(3,4-dimethoxyphenyl)prop-2-enyl]piperazine 2-[[2-(Acetyloxy)benzoyl]oxy]benzoic Acid 2-[(2-Carboxyphenoxy)carbonyl]phenyl Ester

  • 2-(acetyloxy)-benzoylchlorid
  • 2-(Chlorocarbonyl)phenyl acetate
  • Acetylsalicoyl chloride
  • Benzoyl chloride, 2-(acetyloxy)-
  • O-Acetoxybenzoylchloride
  • o-Acetylsalicoyl chloride
  • ASPIRIN CHLORIDE
  • 2-ACETOXYBENZOYL CHLORIDE
  • ACETYLSALICYLOYL CHLORIDE
  • AKOS BBS-00003925
  • O-ACETYLSALICYLOYL CHLORIDE
  • O-Acetylsalicylryl chloride
  • O-Acetylsalicyloylchloride,98%
  • 2-Acetoxybenzoic acid chloride
  • 2-Acetyloxybenzoic acid chloride
  • 2-ACETYLSALICYLOYL CHLORIDE
  • o-Acetylsalicychloride
  • O-Acetylsalicyloyl chloride 97%
  • 2-(acetyloxy)-benzoyl chloride
  • Acetylsalicyloyl chloride,98%
  • O-ACETYLSALICYLOYL C
  • 2-Acetoxybenzoyl chloride SynonyMs: Acetylsalicyloyl chloride
  • <i>O</i>-Acetylsalicyloyl Chloride
  • 2-(Chlorocarbonyl)
  • O-acetylsalicylyl chloride
  • O-Acetylsalicyloyl Chloride &gt
  • Acetylsalicylic Acid Impurity 27
  • SKL1282
  • 2-(carbonochloridoyl)phenyl acetate
  • 5538-51-2
  • 2CH3CO2C6H4COCl
  • ACID CHLORIDE
  • Organic Building Blocks
  • Carbonyl Compounds
  • Building Blocks
  • Acid Halides
  • Acid Halides
  • Building Blocks
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • Acid Halides
  • Carbonyl Compounds
  • Organic Building Blocks