Triflusal
Pharmacological Study- Product Name
- Triflusal
- CAS No.
- 322-79-2
- Chemical Name
- Triflusal
- Synonyms
- ur1501;Drisgen;Disgren;TRIFLUSAL;Triflusal-d3;Triflusal CRS;Triflusal (UR1501);TRIFLUOROTRIMESICACID;4-trifluoromethylsalicylicacidacetate;acetyl-4-trifluoromethylsalicylic acid
- CBNumber
- CB9446472
- Molecular Formula
- C10H7F3O4
- Formula Weight
- 248.16
- MOL File
- 322-79-2.mol
Triflusal Property
- Melting point:
- 120-122° (upon slow heating); 110-112° (upon quick heating)
- Boiling point:
- 316.0±42.0 °C(Predicted)
- Density
- 1.433±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: >30mg/mL
- pka
- 2.97±0.10(Predicted)
- form
- powder
- color
- white to off-white
- λmax
- 297nm(H2O)(lit.)
- Merck
- 14,9688
- CAS DataBase Reference
- 322-79-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-43
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- RTECS
- GP4250000
- HS Code
- 2918.29.7500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- T6580
- Product name
- Triflusal
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- T6580
- Product name
- Triflusal
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $444
- Updated
- 2022/05/15
- Product number
- T3601
- Product name
- Triflusal
- Purity
- >98.0%(T)
- Packaging
- 250mg
- Price
- $274
- Updated
- 2024/03/01
- Product number
- T3601
- Product name
- Triflusal
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $703
- Updated
- 2024/03/01
- Product number
- T2005000
- Product name
- Triflusal
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- t2005000
- Price
- $223
- Updated
- 2024/03/01
Triflusal Chemical Properties,Usage,Production
Pharmacological Study
Triflusal is an antiplatelet agent structurally related to the salicylates, but it is not derived from ASA. Triflusal and its metabolite (3-hydroxy-4-triuoro-methylbenzoic acid or HTB) produce specific inhibition of platelet arachidonic acid metabolism (McNeely and Goa, 1998). A single 12-month open-label trial of tritriflusal in 73 VaD patients (López-Pousa et al., 1997) showed fewer declines in MMSE scores in the active group compared with untreated subjects. More recently, triusal was used in patients with amnesic MCI; 257 patients were randomized to receive 900 mg of triflusal or placebo for 18 months. Triflusal therapy was associated with a signi cantly lower rate of conversion to dementia (Gómez-Isla et al., 2008).
Description
Triflusal is an antiplatelet agent structurally related to the salicylates, but it is not derived from ASA. Triflusal and its metabolite (3-hydroxy-4-triuoro-methylbenzoic acid or HTB) produce specic inhibition of platelet arachidonic acid metabolism (McNeely and Goa, 1998). A single 12-month open-label trial of Triflusal in 73 VaD patients (López-Pousa et al., 1997) showed fewer declines in MMSE scores in the active group compared with untreated subjects. More recently, Triflusal was used in patients with amnesic MCI; 257 patients were randomized to receive 900 mg of Triflusal or placebo for 18 months. Triflusal therapy was associated with a signicantly lower rate of conversion to dementia (Gómez-Isla et al., 2008).
Chemical Properties
White to Off-White Solid
Uses
An analog of Aspirin; inhibits platelet aggregation. Antithrombotic.
Uses
Antithrombotic;Cyclooxygenase inhibitor
Definition
ChEBI: 2-acetyloxy-4-(trifluoromethyl)benzoic acid is a member of salicylates, a carboxylic ester and a member of benzoic acids.
Mechanism of action
2-hydroxy-4-trifluoromethylbenzoic acid (HTB), the deacetylated metabolite of triflusal, retains significant antiplatelet activity. Triflusal is rapidly absorbed and metabolized. The area under the concentration–time curve for triflusal is 20.26 mg/L/hour after a 900-mg dose, whereas that for HTB is 42.27 mg/L/hour. Much of the pharmacokinetic data for triflusal activity is associated with HTB. The inhibition of COX, as measured by reduced production of thromboxane B2, is 25% after 2 hours and 85% after 7 days with triflusal, whereas the effects of aspirin on thromboxane B2 is more than 90% reduction after 2 hours and is maintained at this level after 7 days. It would appear that the presence of a 4-trifluoromethyl group also greatly enhances triflusal's ability to inhibit the activation of nuclear factor κB, which in turn regulates the expression of the mRNA of vascular cell adhesion molecule-1 needed for platelet aggregation. In addition, triflusal increases nitric oxide synthesis in neutrophils, which results in an increased vasodilatory potential. Finally, an additional site of action for triflusal/HTB is the inhibition of cAMP phosphodiesterase, leading to increased levels of cAMP. Elevated cAMP levels decrease platelet aggregation through decreased mobilization of calcium. Aspirin and salicylic acid do not significantly increase cAMP levels.
Clinical Use
Triflusal (2-acetoxy-4-trifluoromethyl benzoic acid) is an antiplatelet drug that despite its structural similarity to aspirin exhibits quite different pharmacological and pharmacokinetic properties.
Triflusal Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Triflusal manufacturers
- Product
- 2-Acetoxy-4-trifluoromethylbenzoic acid 322-79-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150kg
- Release date
- 2019-07-03