ChemicalBook > CAS DataBase List > Ethyl S-4-chloro-3-hydroxybutyrate
Ethyl S-4-chloro-3-hydroxybutyrate
- Product Name
- Ethyl S-4-chloro-3-hydroxybutyrate
- CAS No.
- 86728-85-0
- Chemical Name
- Ethyl S-4-chloro-3-hydroxybutyrate
- Synonyms
- ETHYL (S)-4-CHLORO-3-HYDROXYBUTANOATE;ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE;ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE;SECHB;AST-4;PEFC-026;(S)-(?)-4-chL;(S)-Ethyl 4-chloro-3-;oro-3-hydroxybutyrate;4-chloro-3-hydroxyhexanoate
- CBNumber
- CB9448087
- Molecular Formula
- C6H11ClO3
- Formula Weight
- 166.6
- MOL File
- 86728-85-0.mol
More
Less
Ethyl S-4-chloro-3-hydroxybutyrate Property
- alpha
- -14.5 º (c=neat)
- Boiling point:
- 93-95 °C5 mm Hg(lit.)
- Density
- 1.19 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.453(lit.)
- Flash point:
- 109 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Liquid
- pka
- 13.23±0.20(Predicted)
- color
- Clear colorless to yellow
- optical activity
- [α]23/D 14°, neat
- BRN
- 4657170
- InChI
- InChI=1S/C6H11ClO3/c1-2-10-6(9)3-5(8)4-7/h5,8H,2-4H2,1H3/t5-/m0/s1
- InChIKey
- ZAJNMXDBJKCCAT-YFKPBYRVSA-N
- SMILES
- C(OCC)(=O)C[C@H](O)CCl
- CAS DataBase Reference
- 86728-85-0(CAS DataBase Reference)
More
Less
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 460524
- Product name
- Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate
- Purity
- 96%
- Packaging
- 1g
- Price
- $15.48
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 460524
- Product name
- Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate
- Purity
- 96%
- Packaging
- 5g
- Price
- $29.12
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C1717
- Product name
- Ethyl (S)-4-Chloro-3-hydroxybutyrate
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $47
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C1717
- Product name
- Ethyl (S)-4-Chloro-3-hydroxybutyrate
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $85
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- L18554
- Product name
- Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 98%, ee 98%
- Packaging
- 1g
- Price
- $25.65
- Updated
- 2024/03/01
More
Less
Ethyl S-4-chloro-3-hydroxybutyrate Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow liqui
Uses
Atorvastatin Intermediate
Uses
Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate can be used as a starting material in the synthesis of 4-amino-3-hydroxybutyric acid, a compound of pharmacological importance.
Biosynthesis
Bioreductions catalyzed by alcohol dehydrogenases (ADHs) play an essential role in synthesizing chiral alcohols. A novel ADH, SmADH31, obtained from the Stenotrophomonas maltophilia genome, which can tolerate extremely high concentrations (6 M) of both substrate and product. The coexpression of SmADH31 and glucose dehydrogenase from Bacillus subtilis in Escherichia coli meant that as much as 660 g L–1 (4.0 M) ethyl 4-chloroacetoacetate was completely converted into ethyl (S)-4-chloro-3-hydroxybutyrate [(S)-CHBE] in a monophasic aqueous system with a >99.9% ee value and a high space-time yield (2664 g L–1 d–1). In the 100 ml-scale monophasic aqueous system (in triplicate), 66.0 g COBE (single batch charge) can be completely converted to (S)-CHBE (ee >99.9%) in only 6 h with 2 g of the SmADH31/GDH co-expressing cells. After extraction and evaporation, 61.6 g (S)-CHBE was isolated with 92% yield[1].
General Description
Ethyl (S)-4-chloro-3-hydroxybutanoate is a chiral intermediate generally used to prepare atorvastatin, a cholesterol-lowering drug.
References
[1] Zeyu Yang. “Efficient Asymmetric Synthesis of Ethyl (S)-4-Chloro-3-hydroxybutyrate Using Alcohol Dehydrogenase SmADH31 with High Tolerance of Substrate and Product in a Monophasic Aqueous System.” Organic Process Research & Development 24 6 (2020): 1068–1076.
Ethyl S-4-chloro-3-hydroxybutyrate Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Ethyl S-4-chloro-3-hydroxybutyrate Suppliers
- Tel
- 0523-82837785 13914525028
- Fax
- 0523-87913272
- info@jszchg.com
- Country
- China
- ProdList
- 250
- Advantage
- 60
- Tel
- 0571-86932585
- Fax
- 0571-86932585
- xuandasales@163.com
- Country
- China
- ProdList
- 41
- Advantage
- 58
- Tel
- 0576-88203651 15967007102
- 103858443@qq.com
- Country
- China
- ProdList
- 195
- Advantage
- 58
- Tel
- 18667946270
- wangzeren@synbiolab.cn
- Country
- China
- ProdList
- 32
- Advantage
- 58
- Tel
- 0571-86706360 18158111080
- 3168409019@qq.com
- Country
- China
- ProdList
- 308
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 4986
- Advantage
- 55
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 793-33899567 13735087952
- Fax
- +86-570-6259526
- sales@afmpharm.com
- Country
- China
- ProdList
- 91
- Advantage
- 61
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44733
- Advantage
- 61
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2988
- Advantage
- 65
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-82967028 13552068683
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12443
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14103
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11655
- Advantage
- 64
- Tel
- 86-027-88774375
- Fax
- 86-027-88416321
- mwmwhot@163.com
- Country
- China
- ProdList
- 233
- Advantage
- 65
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9810
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 19185
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- 021-51613915-820 13611835272
- Fax
- 021 51613951
- mmwang@sunwaypharm.cn
- Country
- China
- ProdList
- 9734
- Advantage
- 57
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 4000
- Advantage
- 55
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 0755-4000505016 13380397412
- Fax
- 0755 28094224
- 3001272453@qq.com
- Country
- China
- ProdList
- 5047
- Advantage
- 50
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12335
- Advantage
- 58
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6134
- Advantage
- 55
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 400-6206333 1316706386
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9545
- Advantage
- 55
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- 86-13605431940 13605431940
- Fax
- 0086-0543-2240079
- zpmxchemical@126.com
- Country
- China
- ProdList
- 1481
- Advantage
- 62
- Tel
- +86 0510-85629785
- Fax
- +86 0510-85625359
- Country
- China
- ProdList
- 2327
- Advantage
- 58
- Tel
- 0570-3066667
- Fax
- 0570-3063388
- Country
- China
- ProdList
- 3930
- Advantage
- 58
- Tel
- 0086-571-86217390
- Fax
- 0086-571-86217391
- Sales@gihichem.com
- Country
- China
- ProdList
- 860
- Advantage
- 58
- Tel
- 021-021-64975436 18917636693
- Fax
- 021-24280809
- 1377976036@qq.com
- Country
- China
- ProdList
- 311
- Advantage
- 55
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41457
- Advantage
- 60
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18110
- Advantage
- 56
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
More
Less
View Lastest Price from Ethyl S-4-chloro-3-hydroxybutyrate manufacturers
ShenZhen H&D Pharmaceutical Technology Co., LTD
- Product
- Afatinib impurity 38 86728-85-0
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-06-04
Hebei Chuanghai Biotechnology Co,.LTD
- Product
- Ethyl S-4-chloro-3-hydroxybutyrate 86728-85-0
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-20
Henan Fengda Chemical Co., Ltd
- Product
- Ethyl S-4-chloro-3-hydroxybutyrate 86728-85-0
- Price
- US $8.00-3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03
86728-85-0, Ethyl S-4-chloro-3-hydroxybutyrateRelated Search:
Ethyl butyrate
Ethylbenzene
4-Cyanophenol
4-Hydroxybenzoic acid
Ethyl acrylate
Hydroxy silicone oil
Ethyl acetate
2,3,4-Trihydroxybenzoic acid
Ethyl isobutyrate
Glycolic acid
Ethanol
ETHYL 4-CHLOROBUTYRATE
HYDROXYAPATITE TYPE I
Ethyl formate
Ethylparaben
Ethyl 3-hydroxybutyrate
2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE
Acetoxy Empagliflozin