WITHAFERIN A

ChemicalBook > CAS DataBase List > WITHAFERIN A

Product Name: WITHAFERIN A
CAS No.: 5119-48-2
Chemical Name: WITHAFERIN A
Synonyms: NSC 273757;nsc-101088;upeferinA.;Withaferine;WITHAFERIN A;withaferinea;Withaferin A-RM;Withaferin A Standard;Withaferin A 5119-48-2;delta-lactone,(20s,22r)-oxo
CBNumber: CB9454365
Molecular Formula: C28H38O6
Formula Weight: 470.6
MOL File: 5119-48-2.mol

Less

WITHAFERIN A Property

Melting point:: 252-253℃
alpha: D28 +125° (c = 1.30 in CHCl3)
Boiling point:: 680.7±55.0 °C(Predicted)
Density: 1.28
Flash point:: 226℃
storage temp.: Desiccate at -20°C
solubility: Soluble in DMSO (up to 20 mg/ml)
pka: 13.49±0.70(Predicted)
form: White solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey: DBRXOUCRJQVYJQ-CKNDUULBSA-N

Less

Safety

Hazard Codes: T
WGK Germany: 3
RTECS: KE7288500
HS Code: 29322090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89824
Product name: Withaferin A
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $553
Updated: 2024/03/01

Sigma-Aldrich

Product number: 681535
Product name: Withaferin A
Packaging: 1mg
Price: $144
Updated: 2024/03/01

Sigma-Aldrich

Product number: 681535
Product name: Withaferin A
Packaging: 5mg
Price: $504
Updated: 2024/03/01

Cayman Chemical

Product number: 11352
Product name: Withaferin A
Purity: ≥95%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 11352
Product name: Withaferin A
Purity: ≥95%
Packaging: 5mg
Price: $238
Updated: 2024/03/01

Less

WITHAFERIN A Chemical Properties,Usage,Production

Description

Withaferin A (5119-48-2) displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro?(IC50?= 12 nM) and?in vivo.1?Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2?Covalently binds to the intermediate filament protein, vimentin3?inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis in?in vivo?models.5

Chemical Properties

Solid

Uses

Withaferin A is a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera. Withaferin A showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986). Withaferin A has recently been found to be a leptin sensitizer that can reduce the weight in obese mice fed in a high-fat diet (see C249500).

Definition

ChEBI: A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Phys lis longifolia, it exhibits cytotoxic activity.

Biological Activity

Steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) spouting in vitro (IC 50 = 12 nM) and in vivo . Prevents NF- κ B activation by inhibiting activation of IKK β . Also inhibits chymotrypsin-like activity of the 20S proteasome.

target

ROS | NF-kB | p53 | STAT | PARP | Bcl-2/Bax | Caspase | TGF-β/Smad | TNF-α | COX | PGE | PI3K | Akt | JNK | p38MAPK

storage

Store at -20°C

References

1) Mohan?et al.?(2004),?Withaferin A is a potent inhibitor of angiogenesis; Angiogenesis, 7 115 2) Kaileh?et al.?(2007),?Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with inhibition of its kinase activity; J. Biol. Chem.,?282?4253 3) Bargagna-Mohan?et al.?(2007),?The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin; Chem. Biol.,?14?623 4) Thaiparambil?et al.?(2011),?Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation; Int. J. Cancer,?129?2744 5) Livne-Bar?et al.?(2016),?Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis;?Cell Death Dis.,?7?e2386

WITHAFERIN A Preparation Products And Raw materials

Raw materials

Preparation Products

Less

WITHAFERIN A Suppliers

Canada 2 China 105 France 1 Germany 1 India 4 United Kingdom 5 United States 20 Global 138

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-85370565-229 18080489829
Email: 3004654993@qq.com
Country: China
ProdList: 8899
Advantage: 60

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7887
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 7059
Advantage: 55

Biyu Biotechnology (Shanghai) Co., ltd

Tel: 021-26018599
Country: China
ProdList: 270
Advantage: 56

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7980
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20806
Advantage: 60

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 3990
Advantage: 58

Anhui kuer Bioengineering Co., Ltd

Tel: 0551-65171243 13856024262
Email: kuer@kuerhuaxue.com
Country: China
ProdList: 2997
Advantage: 55

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9577
Advantage: 60

Shanghai Standard Technology Co.,Ltd.

Tel: 021-021-57127007-6622-6622 15618937986
Fax: +86 (21) 5132-0077
Email: zhaok@nature-standard.com
Country: China
ProdList: 3016
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815688 13927872512
Fax: 0751-8963795
Email: 3007421951@qq.com
Country: China
ProdList: 10057
Advantage: 58

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Chengdu Glip Biotechnology Co., Ltd.

Tel: 028-87075086 18030859262
Email: 2851503756@qq.com
Country: China
ProdList: 1926
Advantage: 58

Nanjing Dasf Biotechnology Co., Ltd.

Tel: 025-+86-02585846866 +86-18094231287
Fax: 025-83144123
Email: eric@dasfbio.com
Country: China
ProdList: 1988
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23541
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10319
Advantage: 58

Aktin Chemicals, Inc.

Tel: 028-85159085
Fax: 86-28-85159085 Ex:604
Email: info@aktinchem.com
Country: CHINA
ProdList: 1025
Advantage: 58

Wuhan ChemNorm Biotech Co.,Ltd.

Tel: +86-27-8439 4403 18971486879
Fax: +86-27-8439 4403
Email: sales@chemnorm.com
Country: CHINA
ProdList: 2935
Advantage: 58

Chengdu Gupte Biotechnology Co., Ltd.

Tel: 13881890404
Fax: 028-81711798
Email: 2851503757@qq.com
Country: China
ProdList: 2283
Advantage: 58

Nanning Saifir Biotechnology Co., Ltd.

Tel: 18877121284
Email: 1309367106@qq.com
Country: China
ProdList: 261
Advantage: 58

Chengdu Alfa Biotechnology Co.,Ltd.

Tel: 028-028-85142057 19983342022
Fax: 028-85142057
Email: 3005359975@qq.com
Country: China
ProdList: 1950
Advantage: 58

Shanghai jingkang bioengineering co., ltd.

Tel: 021-54721350 13524668266
Fax: 021-5
Email: 2881505714@qq.com
Country: China
ProdList: 7872
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569266 15319487004
Fax: 029-88380327
Email: 1015@dideu.com
Country: China
ProdList: 4084
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 4297
Advantage: 58

Z-trans Biochemistry Technology (Suzhou) Co.,Ltd

Tel: 0512-66317708 13372112871
Email: huijuan@zitrans.cn
Country: China
ProdList: 1282
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81145920 13259709322
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10009
Advantage: 58

Chengdu PFID reference Technology Co., Ltd

Tel: 028-82610909 15882229804
Email: pufeide@foxmail.com
Country: China
ProdList: 2335
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Wuhan ChemNorm co., LTD.

Tel: 18971486879
Email: 279414929@qq.com
Country: CHINA
ProdList: 2925
Advantage: 58

Shanghai Hewu Biotechnology Co., LTD

Tel: 021-57886085 17317861055
Email: shhebio@126.com
Country: CHINA
ProdList: 7974
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 13626641628
Email: jiangnan@huidabiotech.com
Country: China
ProdList: 3656
Advantage: 58

Less

View Lastest Price from WITHAFERIN A manufacturers

BINBO BIOLOGICAL CO.,LTD

Product: Withaferin A 5119-48-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000 kg
Release date: 2024-04-17

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Withaferin A 5119-48-2 5119-48-2
Price: US $450.00/mg
Min. Order: 10mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-17

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Withaferin A 5119-48-2 5119-48-2
Price: US $450.00/mg
Min. Order: 10mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-17

5119-48-2, WITHAFERIN ARelated Search:

Brassinolide (2alpha,3beta,19alpha)-2,3,19-Trihydroxyolean-12-en-28-oic acid beta-D-glucopyranosyl ester HELENALIN 5-Aminosalicylic acid BAY 11-7085 Kidney Bean Extract BAY 11-7082 ROCAGLAMIDE 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE 3'-Hydroxyrocaglamide panepoxydone WEDELOLACTONE WILFORINE Worenine WILFORDINE BETA-D-GLUCOPYRANOSIDURONIC ACID HYPERICUM PERFORATUM OIL WILFORGINE

WITHAFERIN A

5,6-beta-epoxy-4-beta,22,27-trihydroxy-1-5-beta-ergosta-24-dien-26-oicacid

delta-lactone,(20s,22r)-oxo

nsc-101088

(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone

NSC 273757

Withaferine

(20S,22R)-5,6β-Epoxy-4β,22,27-trihydroxy-1-oxo-5β-ergosta- 2,24-dien-26-oic Acid δ-Lactone

Withaferin A NSC 273757 NSC 101088

5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide

Withaferin A from leaves of Withania somnifera

withaferinea

Ergosta-2,24-dien-26-oicacid, 5,6-epoxy-4,22,27-trihydroxy-1-oxo-, d-lactone, (4b,5b,6b,22R)-

Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem

Withaferin A 5119-48-2

Withaferin A Standard

Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,22,27-trihydroxy-1-oxo-, δ-lactone, (4β,5β,6β,22R)-

AshwagandhaQ: What is Ashwagandha Q: What is the CAS Number of Ashwagandha Q: What is the storage condition of Ashwagandha

(4beta,5beta,6beta,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione

upeferinA.

(4S,4aR,5aR,6aS,6bS,9R,9aS,11aS,11bR)-4-Hydroxy-9-((S)-1-((R)-5-(hydroxymethyl)-4-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-9a,11b-dimethyl-5a,6,6a,6b,7,8,9,9a,10,11,11a,11b-dodecahydrocyclopenta[1,2]phenanthro[8a,9-b]oxiren-1(4H)-one

Withaferin A-RM

5119-48-2

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids

antibiotic