5,6,7,8-TETRAHYDROQUINOLINONE-5
- Product Name
- 5,6,7,8-TETRAHYDROQUINOLINONE-5
- CAS No.
- 53400-41-2
- Chemical Name
- 5,6,7,8-TETRAHYDROQUINOLINONE-5
- Synonyms
- 7,8-dihydroquinolin-5(6H)-one;7,8-dihydroquinolin-5(6H)-one hydrochloride;in-5(6H)-on;7,8-DihydroquinoL;7,8-Dihydro-6H-isoquin-5-one;7,8-dihydro-5(6H)-Quinoli...;7,8-Dihydroquinolin-5(6H)-on;7,8-dihydro-5(6H)-Quinolinone;7,8-DIHYDRO-6H-QUINOLIN-5-ONE;7,8-Dihydroquinoline-5(6H)-one
- CBNumber
- CB9460683
- Molecular Formula
- C9H9NO
- Formula Weight
- 147.17
- MOL File
- 53400-41-2.mol
5,6,7,8-TETRAHYDROQUINOLINONE-5 Property
- Boiling point:
- 116-117 °C(Press: 6 Torr)
- Density
- 1.168±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- pka
- 3.85±0.20(Predicted)
- form
- liquid
- color
- Yellow-brown
- InChI
- InChI=1S/C9H9NO/c11-9-5-1-4-8-7(9)3-2-6-10-8/h2-3,6H,1,4-5H2
- InChIKey
- YHHBKPWMEXGLKE-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(=O)CCC2)C=CC=1
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D450335
- Product name
- 7,8-Dihydro-5(6H)-quinolone
- Packaging
- 50mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- D450335
- Product name
- 7,8-Dihydro-5(6H)-quinolone
- Packaging
- 1g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- D450335
- Product name
- 7,8-Dihydro-5(6H)-quinolone
- Packaging
- 2.5g
- Price
- $715
- Updated
- 2021/12/16
- Product number
- CS-0006841
- Product name
- 5(6H)-Quinolinone,7,8-dihydro-
- Purity
- 99.26%
- Packaging
- 1g
- Price
- $73
- Updated
- 2021/12/16
- Product number
- FD51282
- Product name
- 7,8-Dihydro-6H-quinolin-5-one
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
5,6,7,8-TETRAHYDROQUINOLINONE-5 Chemical Properties,Usage,Production
Uses
7,8-Dihydro-5(6H)-quinolone is used as a reagent in the synthesis of pyridino N-alkylated nicotine analogs which can serve as nicotinic acetylcholine receptor antagonists. 7,8-Dihydro-5(6H)-quinolone is also used in the total synthesis of (±)-tangutorine, a novel indole alkaloid.
Synthesis
10500-57-9
53400-41-2
The general procedure for the synthesis of 5,6,7,8-tetrahydroquinolin-5-one from 5,6,7,8-tetrahydroquinoline was as follows: 0.883 mg of Mn(OTf)2 (0.5 mol%), 67 mg of 5,6,7,8-tetrahydroquinoline, 0.35 g of 65% aqueous TBHP and 2.5 mL of water were added sequentially to 25 mL of a round bottomed flask. The reaction mixture was stirred in air at room temperature for 24 hours. Upon completion of the reaction, the reaction solution was extracted with ethyl acetate (3 x 5 mL), the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the solvent was removed by concentration under reduced pressure. The crude product was purified by silica gel column chromatography using petroleum ether with ethyl acetate (5:1, v/v) as eluent to afford the target compound 5,6,7,8-tetrahydroquinolin-5-one (56.6 mg, 77% yield) as a pale yellow liquid.
References
[1] Patent: CN105669548, 2016, A. Location in patent: Paragraph 0029; 0030
5,6,7,8-TETRAHYDROQUINOLINONE-5 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,6,7,8-TETRAHYDROQUINOLINONE-5 manufacturers
- Product
- 7,8-Dihydro-6H-quinolin-5-one 53400-41-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
- Product
- 5,6,7,8-TETRAHYDROQUINOLINONE-5 53400-41-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-20