7-Amino-3,4-dihydro-1H-quinolin-2-one
- Product Name
- 7-Amino-3,4-dihydro-1H-quinolin-2-one
- CAS No.
- 22246-07-7
- Chemical Name
- 7-Amino-3,4-dihydro-1H-quinolin-2-one
- Synonyms
- 7-Amino-3,4-dihydro-2(1H);7-AMINO-3,4-DIHYDROQUINOLIN-2(1H)-ONE;7-AMINO-3,4-DIHYDRO-2(1H)-QUINOLINONE;7-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;Benzenamine,7-hydrazinyl-N,N-dimethyl-;2(1H)-quinolinone, 7-amino-3,4-dihydro-;7-aMino-1,2,3,4-tetrahydroquinolin-2-one;7-AMINO-1,2,3,4-TETRAHYDRO-2-QUINOLINONE;7-Amino-3,4-dihydro-2(1H)-quinolinone - [A22439];7-amino-3,4-dihydroquinolin-2(1H)-one(SALTDATA: FREE)
- CBNumber
- CB6692885
- Molecular Formula
- C9H10N2O
- Formula Weight
- 162.19
- MOL File
- 22246-07-7.mol
7-Amino-3,4-dihydro-1H-quinolin-2-one Property
- Melting point:
- 213-214 °C
- Boiling point:
- 403.1±45.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 14.65±0.20(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-52
- Safety Statements
- 26
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- A790365
- Product name
- 7-Amino-3,4-dihydro-1H-quinolin-2-one
- Packaging
- 2.5g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- P000398909
- Product name
- 7-Amino-3,4-dihydro-2(1H)-quinolinone
- Purity
- 97%
- Packaging
- 10g
- Price
- $383
- Updated
- 2021/12/16
- Product number
- FA31247
- Product name
- 7-Amino-3,4-dihydro-1H-quinolin-2-one
- Packaging
- 5G
- Price
- $390
- Updated
- 2021/12/16
- Product number
- FA31247
- Product name
- 7-Amino-3,4-dihydro-1H-quinolin-2-one
- Packaging
- 10g
- Price
- $600
- Updated
- 2021/12/16
- Product number
- P000398909
- Product name
- 7-Amino-3,4-dihydro-2(1H)-quinolinone
- Purity
- 97%
- Packaging
- 25g
- Price
- $767
- Updated
- 2021/12/16
7-Amino-3,4-dihydro-1H-quinolin-2-one Chemical Properties,Usage,Production
Synthesis
1613720-64-1
22246-07-7
General procedure for the synthesis of 7-amino-3,4-dihydro-2(1H)-quinolinone from the compound (CAS: 1613720-64-1): firstly, a suspension of Pd(OH)2/C (10%, 3.0 g) and ethyl (E)-3-(2,4-dinitrophenyl)acrylate (12.0 g, 45.1 mmol) in MeOH (80 mL) was was stirred at 25°C. The reaction was carried out under H2 (45 psi) atmosphere for 15 hours. Upon completion of the reaction, the mixture was filtered and the filtrate was concentrated under vacuum to afford ethyl 3-(2,4-diaminophenyl)propionate (8.6 g, 98% yield), which was used directly in the next step of the reaction without further purification. Next, a solution of EtOH (50 mL) of ethyl 3-(2,4-diaminophenyl)propanoate (8.6 g, 41.3 mmol) was stirred at 85-100°C for 48 hours. At the end of the reaction, the reaction mixture was cooled to room temperature and the solvent was removed under vacuum. EtOAc (10 mL) was added to the residue and the precipitate was collected by filtration to afford 7-amino-3,4-dihydro-1H-quinolin-2-one (5.8 g, 87% yield). The product was characterized by 1H NMR (DMSO-d6, 400 MHz): δ 9.83 (brs, 1H), 6.76 (d, J = 7.6 Hz, 1H), 6.12 (m, 2H), 4.95 (brs, 2H), 2.65 (t, J = 7.2 Hz, 2H), 2.36 (t, J = 7.2 Hz, 2H).
References
[1] Patent: US2014/206663, 2014, A1. Location in patent: Paragraph 1265; 1266
7-Amino-3,4-dihydro-1H-quinolin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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