ChemicalBook > CAS DataBase List > 6,7-Dihydro-5H-quinolin-8-one

6,7-Dihydro-5H-quinolin-8-one

Product Name
6,7-Dihydro-5H-quinolin-8-one
CAS No.
56826-69-8
Chemical Name
6,7-Dihydro-5H-quinolin-8-one
Synonyms
6,7-DIHYDROQUINOLIN-8(5H)-ONE;5,6,7,8-tetrahydroquinolin-8-one;in-8-one;AKOS BB-8709;6,7-Dihydro-5H-quinoL;6,7-DIHYDRO-5H-QUINOLIN-8-ONE;6,7-dihydro-1H-quinolin-8-one;6,7-DIHYDRO-5H-QUINOLINE-8-ONE;8(5H)-Quinolinone, 6,7-dihydro-;5,6,7,8-Tetrahydro-8-quinolinone
CBNumber
CB5123526
Molecular Formula
C9H9NO
Formula Weight
147.17
MOL File
56826-69-8.mol
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6,7-Dihydro-5H-quinolin-8-one Property

Melting point:
96-98 °C(Solv: isopropyl ether (108-20-3))
Boiling point:
140 °C(Press: 0.1 Torr)
Density 
1.168±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
pka
3.46±0.20(Predicted)
Appearance
light yellow-brown solid
InChI
InChI=1S/C9H9NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h2,4,6H,1,3,5H2
InChIKey
JIAKIQWNYAZUJD-UHFFFAOYSA-N
SMILES
N1C2=C(CCCC2=O)C=CC=1
CAS DataBase Reference
56826-69-8(CAS DataBase Reference)
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30480
Product name
6,7-Dihydro-5H-quinolin-8-one
Packaging
500mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
30480
Product name
6,7-Dihydro-5H-quinolin-8-one
Packaging
1g
Price
$54
Updated
2024/03/01
Cayman Chemical
Product number
30480
Product name
6,7-Dihydro-5H-quinolin-8-one
Packaging
5g
Price
$166
Updated
2024/03/01
TRC
Product number
D452163
Product name
6,7-Dihydro-5h-quinolin-8-one
Packaging
5g
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD40544
Product name
6,7-Dihydro-5H-quinolin-8-one
Packaging
25g
Price
$300
Updated
2021/12/16
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6,7-Dihydro-5H-quinolin-8-one Chemical Properties,Usage,Production

Description

6,7-Dihydro-5H-quinolin-8-one is a synthetic intermediate. It has been used in the synthesis of tetrahydropyridoazepinones and thiosemicarbazones with anticancer activity.

Chemical Properties

light yellow crystalline

Uses

6,7-Dihydroquinolin-8(5H)-one is a synthetic intermediate useful for pharmaceutical synthesis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 2208, 1984 DOI: 10.1021/jo00186a027
Synthetic Communications, 33, p. 3497, 2003 DOI: 10.1081/SCC-120024729

Synthesis

14631-46-0

56826-69-8

Preparation of 6,7-dihydro-5H-quinolin-8-one: 8-hydroxy-5,6,7,8-tetrahydroquinoline (13.96 g, 93.6 mmol) was dissolved in anhydrous dichloromethane (400 mL) under stirring conditions. Subsequently, activated manganese dioxide (85% pure, 82.22 g, 804 mmol) was added to this solution. The resulting non-homogeneous mixture was stirred for 18 hours. Upon completion of the reaction, the black slurry was filtered through a diatomaceous earth filter cake and the cake was washed with dichloromethane (3 x 50 mL). The washes were combined and concentrated to afford 11.27 g (82% yield) of the target product, 6,7-dihydro-5H-quinolin-8-one, as a light yellow solid, which could be used in subsequent reactions without further purification. The structure of the product was characterized by 1H NMR (CDCl3) δ 2.17-2.25 (m, 2H), 2.82 (t, 2H, J = 7 Hz), 3.04 (t, 2H, J = 6 Hz), 7.37 (dd, 1H, J = 9,6 Hz), 7.66 (dd, 1H, J = 9,1 Hz), 8.71 (dd, 1H, J = 6,1 Hz); 13C NMR (CDCl3) δ 22.2, 28.6, 39.2, 126.6, 137.3, 140.5, 147.6, 148.6, 196.5 confirmed.ES-MS m/z 148 (M + H) further validated the product structure.

References

[1] Patent: US2003/220341, 2003, A1. Location in patent: Page/Page column 9
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 213 - 220
[3] Patent: US2004/19058, 2004, A1

6,7-Dihydro-5H-quinolin-8-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6,7-Dihydro-5H-quinolin-8-one Suppliers

Canada 2 China 169 Germany 2 India 1 Ukraine 1 United Kingdom 4 United States 22 Global 201
Changzhou Langyi Biomedical Technology Co., Ltd.
Tel
13706129682
Email
tiffany@langyupharm.com
Country
China
ProdList
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58
Zhengzhou Alfachem Co.,Ltd.
Tel
0371-53778726 18003825608
Fax
QQ：2885354392
Email
liuxiaoyan@alfachem.cn
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China
ProdList
1986
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
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61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
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56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
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66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
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Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
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64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
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64
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
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57
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View Lastest Price from 6,7-Dihydro-5H-quinolin-8-one manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
6,7-Dihydro-5H-quinolin-8-one 56826-69-8
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18
R&D Scientific Inc.
Product
6,7-Dihydro-5H-quinoline-8-one 56826-69-8
Price
US $780.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-02-19
Hebei Zhanyao Biotechnology Co. Ltd
Product
6,7-Dihydro-5H-quinolin-8-one 56826-69-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-13

56826-69-8, 6,7-Dihydro-5H-quinolin-8-oneRelated Search:

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  • AKOS BB-8709
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  • 6,7-DIHYDRO-5H-QUINOLINE-8-ONE
  • 6,7-DIHYDROQUINOLIN-8(5H)-ONE
  • 6,7-DIHYDRO-5H-QUINOLIN-8-ONE,99+%
  • 6,7-dihydro-5H-quinolin-8-one98%+,
  • 5,6,7,8-tetrahydroquinolin-8-one
  • 8(5H)-Quinolinone, 6,7-dihydro-
  • 8-oxo-5,6,7,8-tetrahydroquinoline
  • 5,6,7,8-Tetrahydro-8-quinolinone
  • 6,7-Dihydro-5H-Quinolin-8-One(WX625030)
  • 56826-69-86,7-Dihydro-5H-quinolin-8-one
  • 6,7-Dihydro-5H-quinoL
  • in-8-one
  • 6,7-dihydro-1H-quinolin-8-one
  • 6,7-Dihydro-5H-quinolin-8-one ISO 9001：2015 REACH
  • TIANFUCHEM--56826-69-8--High purity 6,7-Dihydro-5H-quinolin-8-one factory price
  • 56826-69-8
  • Quinoline Derivertives
  • Heterocycles
  • Heterocyclic Compound