4-THIOANISOLEMAGNESIUM BROMIDE Property

Boiling point:

65 °C

Density 

0.965 g/mL at 25 °C

Flash point:

<1 °F

storage temp. 

2-8°C

form 

Solution

color 

Clear yellow to brown

Safety

Hazard Codes 

F,C,F+

Risk Statements 

11-14-19-34-12-37-40

Safety Statements 

16-26-36/37/39-45

RIDADR 

UN 2924 3/PG 2

WGK Germany 

1

HS Code 

29309090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

4-THIOANISOLEMAGNESIUM BROMIDE Chemical Properties,Usage,Production

Chemical Properties

Tan liquid

Uses

4-Thioanisolemagnesium bromide can be used to prepare:

• 3,3-Ethylenedioxy-5a-hydroxy-11b-[4-(thiomethoxy)phenyl]-estr-9-en-17-one, a key intermediate for the synthesis of mifepristone analogs.
• (1S)-1,4-Anhydro-2,3,5,6-tetra-O-benzyl-1-C-[4-chloro-3-(4-methylthiobenzyl)-phenyl]-D-glucitol, a key intermediate for the synthesis of aryl?D-glucofuranosides as potent hSGLT2 and hSGLT1 inhibitors.

reaction suitability

reaction type: Grignard Reaction