4-acetamidobenzoic acid
- Product Name
- 4-acetamidobenzoic acid
- CAS No.
- 556-08-1
- Chemical Name
- 4-acetamidobenzoic acid
- Synonyms
- P-ACETAMIDOBENZOIC ACID;4-ACETAMIDOBENZOIC ACID;Acedoben;p-acetamidobenzoic;PAAB;P-ACETAMINOBENZOIC ACID;4-ACETAMIDOBENZOIC ACID FOR SYNTHESIS;p-Acetylamino benzoic acido benzoic acid;LR-64;PAABA
- CBNumber
- CB9465840
- Molecular Formula
- C9H9NO3
- Formula Weight
- 179.17
- MOL File
- 556-08-1.mol
4-acetamidobenzoic acid Property
- Melting point:
- 259-262 °C (dec.)(lit.)
- Boiling point:
- 311.69°C (rough estimate)
- Density
- 1.2822 (rough estimate)
- refractive index
- 1.5600 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Powder
- pka
- pK1: 4.28 (25°C)
- color
- Off-white to slightly beige
- Water Solubility
- <0.1 g/100 mL at 21 ºC
- BRN
- 390602
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 556-08-1(CAS DataBase Reference)
- NIST Chemistry Reference
- N-(4-Carboxyphenyl)acetic acid amide(556-08-1)
- EPA Substance Registry System
- Benzoic acid, 4-(acetylamino)- (556-08-1)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 133337
- Product name
- 4-Acetamidobenzoic acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $40.7
- Updated
- 2025/07/31
- Product number
- A0013
- Product name
- 4-Acetamidobenzoic Acid
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- A0013
- Product name
- 4-Acetamidobenzoic Acid
- Purity
- >99.0%(T)
- Packaging
- 500g
- Price
- $173
- Updated
- 2025/07/31
- Product number
- 001043
- Product name
- Acedoben
- Packaging
- 5g
- Price
- $312
- Updated
- 2021/12/16
- Product number
- A130500
- Product name
- Acedoben
- Packaging
- 50g
- Price
- $340
- Updated
- 2021/12/16
4-acetamidobenzoic acid Chemical Properties,Usage,Production
Description
4-Acetamidobenzoic acid (PAcBA) is a naturally occurring acetylated metabolite of 4-aminobenzoic acid and is a component of the antiviral and immunostimulatory drug inosine pranobex (Inosiplex; Isoprinosine; Methisoprinol).
Chemical Properties
white or off-white powder or crystals
Originator
4-Acetamidobenzoic acid ,ARIAC
Uses
immune stimulant (component)
Uses
Acedoben is the acetylated derivative of p-aminobenzoic acid (PABA). Acedoben is a metabolite of the anesthetic Benzocaine (B202970).
Definition
ChEBI: 4-acetamidobenzoic acid is a amidobenzoic acid that consists of benzoic acid bearing an acetamido substituent at position 4. It is functionally related to a 4-aminobenzoic acid. It is a conjugate acid of a 4-acetamidobenzoate.
Manufacturing Process
Into a 2 L, 3-necked flask set in a tub and equipped with a stirrer, an air condenser (drying tube), thermometer, was placed 860 ml of water, 43.0 g of MgSO4 and 43.0 g of sodium acetate and heated on water bath. Into heated solution to 70°C stirring 43.0 g of N-p-tolylacetamide were added. Then 136.0 g of KMnO4 by small portions were added at 75°-80°C. The reaction mixture allow to stand for 6 h and stirring was continue till the solution became colorless. Hot solution was filtered and filtrate treated hydrochloric acid to slightly acidic pH. After that 44.0 g (85%) of p-acetoaminobenzoic acid was obtained as white precipitate, melting point 250°C.
Therapeutic Function
Antiviral
General Description
Needles or off-white powder.
Air & Water Reactions
Water insoluble.
Reactivity Profile
Simultaneously an amide and a carboxylic acid.
Fire Hazard
Flash point data for p-Acetylamino benzoic acid are not available; however, p-Acetylamino benzoic acid is probably combustible.
reaction suitability
reaction type: solution phase peptide synthesis
References
[1] Synthetic Communications, 2008, vol. 38, # 7, p. 1028 - 1035
[2] Applied Catalysis A: General, 2013, vol. 456, p. 118 - 125
[3] Green Chemistry, 2012, vol. 14, # 3, p. 847 - 854
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010, vol. 49, # 9, p. 1274 - 1281
[5] Synthetic Communications, 2008, vol. 38, # 17, p. 2929 - 2940
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Raw materials
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View Lastest Price from 4-acetamidobenzoic acid manufacturers
- Product
- 4-Acetamidobenzoic acid 556-08-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100tons
- Release date
- 2025-11-20
- Product
- p-Acetylamino benzoic acid 556-08-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- p-Acetylamino benzoic acid 556-08-1
- Price
- US $10.00-3.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-09-28