3-Fluoro-2-nitrophenol
- Product Name
- 3-Fluoro-2-nitrophenol
- CAS No.
- 385-01-3
- Chemical Name
- 3-Fluoro-2-nitrophenol
- Synonyms
- 2-nitro-fluorophenol;2-nitro-3-fluorophenol;2-Fluoro-3-nitrophenol;3-FLUORO-2-NITROPHENOL;Phenol, 3-fluoro-2-nitro-;3-Fluoro-2-nitrophenol >3-Fluoro-2-nitrophenol 97%;3-Fluoro-2-nitrophenol, 97%+;2-Fluoro-6-hydroxynitrobenzene
- CBNumber
- CB9471799
- Molecular Formula
- C6H4FNO3
- Formula Weight
- 157.1
- MOL File
- 385-01-3.mol
3-Fluoro-2-nitrophenol Property
- Melting point:
- 37-38°C
- Boiling point:
- 237.6±20.0 °C(Predicted)
- Density
- 1.511±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- Solid
- pka
- 3.56±0.10(Predicted)
- color
- Light yellow to Brown
- CAS DataBase Reference
- 385-01-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 34
- Safety Statements
- 36/37/39-45
- HazardClass
- IRRITANT
- HS Code
- 2908990000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS004611
- Product name
- 3-Fluoro-2-nitrophenol
- Purity
- AldrichCPR
- Packaging
- 100MG
- Price
- $70.9
- Updated
- 2024/03/01
- Product number
- F0947
- Product name
- 3-Fluoro-2-nitrophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- F0947
- Product name
- 3-Fluoro-2-nitrophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $95
- Updated
- 2025/07/31
- Product number
- F597630
- Product name
- 3-Fluoro-2-nitrophenol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- F597630
- Product name
- 3-Fluoro-2-nitrophenol
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
3-Fluoro-2-nitrophenol Chemical Properties,Usage,Production
Chemical Properties
Off-white crystalline
Synthesis
19064-24-5
385-01-3
General procedure for the synthesis of 3-fluoro-2-nitrophenol from 2,6-difluoronitrobenzene: First, potassium TERT-butoxide (1.23 g, 11 mmol) was dissolved in 25 mL of anhydrous DMSO and stirred for 30 min at room temperature. Subsequently, 1,3-difluoro-2-nitrobenzene (1.59 g, 10 mmol) was added and the reaction was continued with stirring for 18 hours. After completion of the reaction, the mixture was diluted with 150 mL of aqueous 1N sulfuric acid and extracted with three 50 mL portions of diethyl ether. The organic layers were combined, washed with water, dried over sodium sulfate, filtered and concentrated in vacuum. The residue was dissolved in 50mL of trifluoroacetic acid and reacted for 30 minutes at room temperature before being concentrated again under vacuum. Next, the residue was treated with 50mL of 1N aqueous sodium hydroxide and extracted with three 30mL portions of diethyl ether. The aqueous layer was acidified with 1N aqueous sulfuric acid solution and extracted with two 50mL dichloromethane. The dichloromethane layers were combined, washed with water, dried over sodium sulfate, filtered and concentrated in vacuum to give 1.3 g of 3-fluoro-2-nitrophenol as an orange oil (61% yield). Next, 3-fluoro-2-nitrophenol (1.13 g, 7.2 mmol) and pyridine (0.65 mL, 8 mmol) were dissolved in 15 mL of anhydrous dichloromethane and cooled in an ice bath. A solution of trifluoromethanesulfonic anhydride (1.33 mL, 7.9 mmol) dissolved in 3 mL of anhydrous dichloromethane was added slowly. After 4 hours of reaction, the reaction mixture was diluted with 100 mL of dichloromethane and washed sequentially with two 30 mL aqueous saturated sodium bicarbonate solutions, two 30 mL aqueous 1N sulfuric acid solutions, and two 30 mL of water. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuum to give 2 g of the target product as a light brown oil (96% yield).
References
[1] Patent: WO2005/30213, 2005, A1. Location in patent: Page/Page column 182-183
[2] Magnetic Resonance in Chemistry, 1996, vol. 34, # 6, p. 440 - 446
[3] Journal of Labelled Compounds and Radiopharmaceuticals, 2006, vol. 49, # 7, p. 623 - 634
[4] Patent: WO2011/106986, 2011, A1
[5] ChemMedChem, 2017, vol. 12, # 17, p. 1436 - 1448
3-Fluoro-2-nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Fluoro-2-nitrophenol manufacturers
- Product
- 3-Fluoro-2-nitrophenol 385-01-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- g/kg/T
- Release date
- 2019-12-18