POMALIDOMIDE-PEG2-ALKYNE

Product Name
POMALIDOMIDE-PEG2-ALKYNE
Chemical Name
POMALIDOMIDE-PEG2-ALKYNE
Synonyms
POMALIDOMIDE-PEG2-ALKYNE
CBNumber
CB94744213
Formula Weight
0
MOL File
Mol file
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POMALIDOMIDE-PEG2-ALKYNE Property

storage temp. 
2-8°C
form 
powder or crystals
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901529
Product name
Pomalidomide-PEG2-Alkyne
Purity
≥95%
Packaging
50MG
Price
$780
Updated
2023/06/20
Iris Biotech GmbH
Product number
PTC1410
Product name
Pomalidomide-PEG2-Alkyne
Packaging
50mg
Price
$648
Updated
2021/12/16
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POMALIDOMIDE-PEG2-ALKYNE Chemical Properties,Usage,Production

Uses

Protein degrader builiding block Pomalidomide-PEG2-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

POMALIDOMIDE-PEG2-ALKYNE Preparation Products And Raw materials

Raw materials

Preparation Products

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POMALIDOMIDE-PEG2-ALKYNE Suppliers

Sigma-Aldrich Japan K.K.
Tel
--
Fax
--
Email
sialjp@sial.com
Country
Japan
ProdList
5753
Advantage
58