9-Phenylacridine

Product Name: 9-Phenylacridine
CAS No.: 602-56-2
Chemical Name: 9-Phenylacridine
Synonyms: 9-PA;phenylacridine;9-phenyl-acridin;9-PHENYLACRIDINE;9-Phenylacridine>Acridine, 9-phenyl-;9-Phenylacridin (9-PA);3-propan-2-yloxy-1-cyclohex-2-enone;TIANFU-CHEM CAS:602-56-2 9-Phenylacridine
CBNumber: CB9478127
Molecular Formula: C19H13N
Formula Weight: 255.31
MOL File: 602-56-2.mol

More

Less

9-Phenylacridine Property

Melting point:: 184°C
Boiling point:: 388.54°C (rough estimate)
Density: 0.9418 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 5.45±0.10(Predicted)
color: Light yellow to Amber to Dark green
InChI: InChI=1S/C19H13N/c1-2-8-14(9-3-1)19-15-10-4-6-12-17(15)20-18-13-7-5-11-16(18)19/h1-13H
InChIKey: MTRFEWTWIPAXLG-UHFFFAOYSA-N
SMILES: C1C2C(=NC3C(C=2C2=CC=CC=C2)=CC=CC=3)C=CC=1
CAS DataBase Reference: 602-56-2(CAS DataBase Reference)
NIST Chemistry Reference: Acridine, 9-phenyl-(602-56-2)
EPA Substance Registry System: Acridine, 9-phenyl- (602-56-2)

More

Less

Safety

Safety Statements: 22-24/25
HS Code: 2933.99.8210

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: P1198
Product name: 9-Phenylacridine
Purity: >98.0%(GC)
Packaging: 10g
Price: $135
Updated: 2024/03/01

Chem-Impex

Product number: 42560
Product name: 9-Phenylacridine,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 10G
Price: $138.66
Updated: 2021/12/16

Matrix Scientific

Product number: 100650
Product name: 9-Phenylacridine
Purity: 95+%
Packaging: 10g
Price: $168
Updated: 2021/12/16

AK Scientific

Product number: 8980AB
Product name: 9-Phenylacridine
Packaging: 25g
Price: $303
Updated: 2021/12/16

Matrix Scientific

Product number: 100650
Product name: 9-Phenylacridine
Purity: 95+%
Packaging: 100g
Price: $945
Updated: 2021/12/16

More

Less

9-Phenylacridine Chemical Properties,Usage,Production

Uses

Research has found that 9-phenylacridine (ACPH) exhibited anticancer activity in cell lines and in vivo animal models. Bioinformatics studies have indicated that it could have topoisomerase I inhibitory activity. It could also act as a PARP 1 inhibitor and was very effective in combination with cisplatin in cell line-based assays. ACPH also satisfied all criteria for a candidate drug from the Lipinski rule and showed good cell uptake. ACPH alone was effective in the A375 melanoma cell line. ACPH could be used as a promising new photosensitizer[1-2]. 9-Phenylacridine is the parent base of chrysaniline or 3,6-diamino-9- phenylacridine, the chief constituent of the dyestuff phosphine. It is commonly used in the electronics industry as a free radical photoinitiator, significantly improving photo speed.

Description

9-Phenylacridine has antitumour activity. It can be used as a photosensitiser and can sensitise UVA-induced DNA damage in vitro and in cells. It also enhances cell killing by UVA. In addition. It is also used in photochemical research and as a raw material for organic synthesis.

Biological Activity

Hansda et al. suggested that a nontoxic dose of 9-Phenylacridine (ACPH) with UVA light can inhibit the proliferation of A375 cells by inducing DNA damage both in in vitro DNA and in cells through photosensitization. Such treatment enhanced the generation of ROS in cells, leading to lipid peroxidation and depletion of GSH. This led to cell cycle arrest at the G2/M phase to promote apoptosis through the mitochondria-mediated pathway. Although there was a slight increase in the small population of cells undergoing death through autophagy by UVA on ACPH pretreatment, primarily UVA+ACPH resulted in cell death through apoptosis. Thus, using ACPH as a photosensitizer in PDT may be contemplated. Applying ACPH topically to target cells and then illuminating them with UVA can minimize the concern of inducing damage to the surrounding normal cells [1].

References

[1] Surajit Hansda, Rita Ghosh, Gargi Ghosh. "9-phenyl acridine photosensitizes A375 cells to UVA radiation." Heliyon (2020): e04733.
[2] Rita Ghosh, Dipanjan Guha, Sudipta Bhowmik. "9-phenyl acridine exhibits antitumour activity by inducing apoptosis in A375 cells." Molecular and Cellular Biochemistry 361 1–2 (2012): 55–66.

9-Phenylacridine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

9-Phenylacridine Suppliers

Americas 1 China 149 Europe 1 Germany 4 India 7 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 6 United States 15 Global 187

WISPO?Advanced?Materials?(Suzhou) Co., Ltd.

Tel: 18112619888
Email: service@wispo.com.cn
Country: China
ProdList: 22
Advantage: 58

Zhengzhou Yuanli Biological Technology Co., Ltd.

Tel: 0371-67897870 18339906974
Fax: 0371-63507390
Email: 2130541246@qq.com
Country: China
ProdList: 109
Advantage: 58

Shanghai Fansheng Chemical Technology Co., LTD

Tel: 021-33927391-803 15601735299
Email: danty@function-chem.com
Country: China
ProdList: 31
Advantage: 58

Xinyang Longye Chemical Products Co., Ltd.

Tel: 15737681111 15737681111
Email: 3683985493@qq.com
Country: China
ProdList: 275
Advantage: 58

Tianjin Zhongxin Chemtech Co., Ltd.

Tel: 022-66880623
Fax: 86(0)22-66880086
Email: sales@tjzxchem.com
Country: China
ProdList: 613
Advantage: 60

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

More

Less

View Lastest Price from 9-Phenylacridine manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 9-Phenylacridine 602-56-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

Hebei Yanxi Chemical Co., Ltd.

Product: 9-Phenylacridine 602-56-2
Price: US $30.00-9.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 5 tons
Release date: 2023-11-16

Henan Aochuang Chemical Co.,Ltd.

Product: 9-Phenylacridine 602-56-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

602-56-2, 9-PhenylacridineRelated Search:

Quinacridone 9(10H)-ACRIDONE Basic Orange 14 6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE Amsacrine hydrochloride 2-ETHOXY-6,9-DIAMINOACRIDINE 10-METHYL-9-PHENYLACRIDINIUM PERCHLORATE CI 46045 9,10-Dihydro-9-phenylacridine 4-(9-Acridinyl)-N,N-dimethylaniline 9-MESITYL-10-METHYLACRIDINIUM PERCHLORATE PHOSPHINE E 9-(2,6-DIMETHYLPHENYL)-10-METHYLACRIDINIUM PERCHLORATE 9-(2-BIPHENYLYL)-10-METHYLACRIDINIUM PERCHLORATE BENZOFLAVIN 9-(2,5-DIMETHYLPHENYL)-10-METHYLACRIDINIUM PERCHLORATE 2-chloro-9-phenylacridine 9-CHLORO-9-(4'-DIETHYLAMINO)PHENYL-9,10-DIHYDRO-10-PHENYLACRIDINE HYDROCHLORIDE

9-phenyl-acridin

9-Phenylacridin (9-PA)

3-propan-2-yloxy-1-cyclohex-2-enone

phenylacridine

9-PHENYLACRIDINE

9-PA

Acridine, 9-phenyl-

9-Phenylacridine&gt

TIANFU-CHEM CAS:602-56-2 9-Phenylacridine

602-56-2

C19H13N

Miscellaneous