9-Phenylacridine

Product Name: 9-Phenylacridine
CAS No.: 602-56-2
Chemical Name: 9-Phenylacridine
Synonyms: 9-PA;phenylacridine;9-phenyl-acridin;9-PHENYLACRIDINE;9-Phenylacridine>Acridine, 9-phenyl-;9-Phenylacridin (9-PA);3-propan-2-yloxy-1-cyclohex-2-enone;TIANFU-CHEM CAS:602-56-2 9-Phenylacridine
CBNumber: CB9478127
Molecular Formula: C19H13N
Formula Weight: 255.31
MOL File: 602-56-2.mol

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9-Phenylacridine Property

Melting point:: 184°C
Boiling point:: 388.54°C (rough estimate)
Density: 0.9418 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 5.45±0.10(Predicted)
color: Light yellow to Amber to Dark green
InChI: InChI=1S/C19H13N/c1-2-8-14(9-3-1)19-15-10-4-6-12-17(15)20-18-13-7-5-11-16(18)19/h1-13H
InChIKey: MTRFEWTWIPAXLG-UHFFFAOYSA-N
SMILES: C1C2C(=NC3C(C=2C2=CC=CC=C2)=CC=CC=3)C=CC=1
CAS DataBase Reference: 602-56-2(CAS DataBase Reference)
NIST Chemistry Reference: Acridine, 9-phenyl-(602-56-2)
EPA Substance Registry System: Acridine, 9-phenyl- (602-56-2)

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Safety

Safety Statements: 22-24/25
HS Code: 2933.99.8210

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P1198
Product name: 9-Phenylacridine
Purity: >98.0%(GC)
Packaging: 10g
Price: $135
Updated: 2024/03/01

Chem-Impex

Product number: 42560
Product name: 9-Phenylacridine,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 10G
Price: $138.66
Updated: 2021/12/16

Matrix Scientific

Product number: 100650
Product name: 9-Phenylacridine
Purity: 95+%
Packaging: 10g
Price: $168
Updated: 2021/12/16

AK Scientific

Product number: 8980AB
Product name: 9-Phenylacridine
Packaging: 25g
Price: $303
Updated: 2021/12/16

Matrix Scientific

Product number: 100650
Product name: 9-Phenylacridine
Purity: 95+%
Packaging: 100g
Price: $945
Updated: 2021/12/16

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9-Phenylacridine Chemical Properties,Usage,Production

Uses

Research has found that 9-phenylacridine (ACPH) exhibited anticancer activity in cell lines and in vivo animal models. Bioinformatics studies have indicated that it could have topoisomerase I inhibitory activity. It could also act as a PARP 1 inhibitor and was very effective in combination with cisplatin in cell line-based assays. ACPH also satisfied all criteria for a candidate drug from the Lipinski rule and showed good cell uptake. ACPH alone was effective in the A375 melanoma cell line. ACPH could be used as a promising new photosensitizer[1-2]. 9-Phenylacridine is the parent base of chrysaniline or 3,6-diamino-9- phenylacridine, the chief constituent of the dyestuff phosphine. It is commonly used in the electronics industry as a free radical photoinitiator, significantly improving photo speed.

Description

9-Phenylacridine has antitumour activity. It can be used as a photosensitiser and can sensitise UVA-induced DNA damage in vitro and in cells. It also enhances cell killing by UVA. In addition. It is also used in photochemical research and as a raw material for organic synthesis.

Biological Activity

Hansda et al. suggested that a nontoxic dose of 9-Phenylacridine (ACPH) with UVA light can inhibit the proliferation of A375 cells by inducing DNA damage both in in vitro DNA and in cells through photosensitization. Such treatment enhanced the generation of ROS in cells, leading to lipid peroxidation and depletion of GSH. This led to cell cycle arrest at the G2/M phase to promote apoptosis through the mitochondria-mediated pathway. Although there was a slight increase in the small population of cells undergoing death through autophagy by UVA on ACPH pretreatment, primarily UVA+ACPH resulted in cell death through apoptosis. Thus, using ACPH as a photosensitizer in PDT may be contemplated. Applying ACPH topically to target cells and then illuminating them with UVA can minimize the concern of inducing damage to the surrounding normal cells [1].

References

[1] Surajit Hansda, Rita Ghosh, Gargi Ghosh. "9-phenyl acridine photosensitizes A375 cells to UVA radiation." Heliyon (2020): e04733.
[2] Rita Ghosh, Dipanjan Guha, Sudipta Bhowmik. "9-phenyl acridine exhibits antitumour activity by inducing apoptosis in A375 cells." Molecular and Cellular Biochemistry 361 1–2 (2012): 55–66.

9-Phenylacridine Preparation Products And Raw materials

Raw materials

Preparation Products

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9-Phenylacridine Suppliers

Americas 1 China 149 Europe 1 Germany 4 India 7 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 6 United States 15 Global 187

Aladdin Scientific

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Matrix Scientific

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View Lastest Price from 9-Phenylacridine manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 9-Phenylacridine 602-56-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

Hebei Yanxi Chemical Co., Ltd.

Product: 9-Phenylacridine 602-56-2
Price: US $30.00-9.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 5 tons
Release date: 2023-11-16

Henan Aochuang Chemical Co.,Ltd.

Product: 9-Phenylacridine 602-56-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

602-56-2, 9-PhenylacridineRelated Search:

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9-phenyl-acridin

9-Phenylacridin (9-PA)

3-propan-2-yloxy-1-cyclohex-2-enone

phenylacridine

9-PHENYLACRIDINE

9-PA

Acridine, 9-phenyl-

9-Phenylacridine&gt

TIANFU-CHEM CAS:602-56-2 9-Phenylacridine

602-56-2

C19H13N

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