LY 345899)
- Product Name
- LY 345899)
- CAS No.
- 10538-99-5
- Chemical Name
- LY 345899)
- Synonyms
- LY 345899);LY-345899 (LY345899;inhibit,LY345899,LY-345899,Inhibitor,LY 345899,Methylenetetrahydrofolate Dehydrogenase (MTHFD);L-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1,9-dioxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-;(2S)-2-(4-(3-Amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioic acid
- CBNumber
- CB94845002
- Molecular Formula
- C20H21N7O7
- Formula Weight
- 471.42
- MOL File
- 10538-99-5.mol
LY 345899) Property
- Density
- 1.82±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:125.0(Max Conc. mg/mL);265.16(Max Conc. mM)
- form
- A solid
- pka
- 3.46±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A786224
- Product name
- (2S)-2-(4-(3-Amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioicacid
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $479
- Updated
- 2021/12/16
- Product number
- A786224
- Product name
- (2S)-2-(4-(3-Amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioicacid
- Purity
- 95+%
- Packaging
- 50mg
- Price
- $1349
- Updated
- 2021/12/16
- Product number
- DC22784
- Product name
- LY-345899
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1700
- Updated
- 2021/12/16
- Product number
- DC22784
- Product name
- LY-345899
- Purity
- >98%
- Packaging
- 1g
- Price
- $3600
- Updated
- 2021/12/16
LY 345899) Chemical Properties,Usage,Production
Biological Activity
LY 345899, a folate analog, is also a methylenetetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inhibitor with IC50 values of 96 nM and 663 nM, respectively, and Ki value for MTHFD1 of 18 nM.
in vitro
LY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria.
LY 345899 could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis.
in vivo
LY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo .
| SW620 or PDX-based BABL/c nude colorectal cancer (CRC) model | |
| 5-10 mg/kg | |
| Administration: | Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks |
| Result : | Displayed lower cell proliferation indices and higher cell apoptosis. Exhibited no statistically significant weight loss or other signs of acute or delayed toxicity in mice. |