DEOXYCHOLIC-2,2,4,4-D4 ACID
- Product Name
- DEOXYCHOLIC-2,2,4,4-D4 ACID
- CAS No.
- 112076-61-6
- Chemical Name
- DEOXYCHOLIC-2,2,4,4-D4 ACID
- Synonyms
- Deoxycholic acid-D;Deoxycholic-d4 Acid;D4-Deoxycholic Acid;2H4]-Deoxycholic acid;DEOXYCHOLIC-2,2,4,4-D4 ACID;Deoxycholic acid-2,2,4,4-d4;Deoxycholic Acid-[d4] (Solution);Deoxycholic Acid-[d4] in Methanol;Deoxycholic acid (2,2,4,4-D?, 98%);Deoxycholic Acid-d4 MaxSpec? Standard
- CBNumber
- CB9491841
- Molecular Formula
- C24H40O4
- Formula Weight
- 392.58
- MOL File
- 112076-61-6.mol
DEOXYCHOLIC-2,2,4,4-D4 ACID Property
- Melting point:
- 171-174 °C
- Flash point:
- 9℃
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- CAS Number Unlabeled
- 83-44-3
- CAS Number Unlabeled
- 83-44-3
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H370Causes damage to organs
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- 20851
- Product name
- Deoxycholic Acid-d4
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 20851
- Product name
- Deoxycholic Acid-d4
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 20851
- Product name
- Deoxycholic Acid-d4
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- RDL0006065
- Product name
- DEOXYCHOLIC ACID-2,2,4,4-D4
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $903.5
- Updated
- 2021/12/16
- Product number
- RDL0006065
- Product name
- DEOXYCHOLIC ACID-2,2,4,4-D4
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $1146.05
- Updated
- 2021/12/16
DEOXYCHOLIC-2,2,4,4-D4 ACID Chemical Properties,Usage,Production
Description
Deoxycholic acid-d4 (DCA-d4) is intended for use as an internal standard for the quantification of DCA (Item Nos. 20756 | 18231) by GC- or LC-MS. DCA is a secondary bile acid that is formed via microbial transformation of cholic acid in the colon. It can be conjugated to glycine or taurine to produce glycodeoxycholic acid (GDCA; ) or taurodeoxycholic acid (TDCA; ), respectively, in hepatocytes. DCA (0.2% v/v) inhibits spore germination induced by taurocholic acid (TCA; ) in seven C. difficile strains, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.02% v/v. It inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells when used at a concentration of 200 μM. Fecal and intestinal tissue levels of DCA are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet. Increased serum DCA levels have been found in patients with colorectal cancer.
Uses
Deoxycholic-2,2,4,4-d4 Acid (CAS# 112076-61-6) is a useful isotopically labeled research compound.
Definition
ChEBI: Deoxycholic acid-2,2,4,4-d4 is a deuterated compound and a deoxycholic acid.
References
[1] RAJANI THANISSERY Casey M T Jenessa A Winston. Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids[J]. Anaerobe, 2017, 45: Pages 86-100. DOI: 10.1016/j.anaerobe.2017.03.004
[2] D. QIAO. Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation.[J]. Carcinogenesis, 2001, 22 6 1: 957-964. DOI: 10.1093/carcin/22.6.957
[3] HONG LIN. Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model[J]. Journal of Agricultural and Food Chemistry, 2019, 67 13: 3624-3632. DOI: 10.1021/acs.jafc.9b00249
[4] EKKEHARD BAYERD?RFFER . Increased serum deoxycholic acid levels in men with colorectal adenomas[J]. Gastroenterology, 1993, 104 1: Pages 145-151. DOI: 10.1016/0016-5085(93)90846-5
DEOXYCHOLIC-2,2,4,4-D4 ACID Preparation Products And Raw materials
Raw materials
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