DEOXYCHOLIC-2,2,4,4-D4 ACID

Product Name: DEOXYCHOLIC-2,2,4,4-D4 ACID
CAS No.: 112076-61-6
Chemical Name: DEOXYCHOLIC-2,2,4,4-D4 ACID
Synonyms: Deoxycholic acid-D;Deoxycholic-d4 Acid;D4-Deoxycholic Acid;2H4]-Deoxycholic acid;DEOXYCHOLIC-2,2,4,4-D4 ACID;Deoxycholic acid-2,2,4,4-d4;Deoxycholic Acid-[d4] (Solution);Deoxycholic Acid-[d4] in Methanol;Deoxycholic acid (2,2,4,4-D?, 98%);Deoxycholic Acid-d4 MaxSpec? Standard
CBNumber: CB9491841
Molecular Formula: C24H40O4
Formula Weight: 392.58
MOL File: 112076-61-6.mol

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DEOXYCHOLIC-2,2,4,4-D4 ACID Property

Melting point:: 171-174 °C
Flash point:: 9℃
storage temp.: -20°C
solubility: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form: Solid
color: White to Off-White
CAS Number Unlabeled: 83-44-3
CAS Number Unlabeled: 83-44-3

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20851
Product name: Deoxycholic Acid-d4
Purity: ≥95%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 20851
Product name: Deoxycholic Acid-d4
Purity: ≥95%
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 20851
Product name: Deoxycholic Acid-d4
Purity: ≥95%
Packaging: 10mg
Price: $477
Updated: 2024/03/01

IsoSciences

Product number: 13100
Product name: Deoxycholic acid-D4
Purity: ≥98%
Packaging: 10mg
Price: $130
Updated: 2021/12/16

IsoSciences

Product number: S13100-0.1
Product name: DeoxycholicAcid-[d4](Solution)
Purity: ≥98%
Packaging: 100ug/mL
Price: $163
Updated: 2021/12/16

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DEOXYCHOLIC-2,2,4,4-D4 ACID Chemical Properties,Usage,Production

Description

Deoxycholic acid-d₄ (DCA-d₄) is intended for use as an internal standard for the quantification of DCA (Item Nos. 20756 | 18231) by GC- or LC-MS. DCA is a secondary bile acid that is formed via microbial transformation of cholic acid in the colon. It can be conjugated to glycine or taurine to produce glycodeoxycholic acid (GDCA; ) or taurodeoxycholic acid (TDCA; ), respectively, in hepatocytes. DCA (0.2% v/v) inhibits spore germination induced by taurocholic acid (TCA; ) in seven C. difficile strains, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.02% v/v. It inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells when used at a concentration of 200 μM. Fecal and intestinal tissue levels of DCA are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet. Increased serum DCA levels have been found in patients with colorectal cancer.

Uses

Deoxycholic-2,2,4,4-d4 Acid (CAS# 112076-61-6) is a useful isotopically labeled research compound.

Definition

ChEBI: Deoxycholic acid-2,2,4,4-d4 is a deuterated compound and a deoxycholic acid.

References

[1] RAJANI THANISSERY Casey M T Jenessa A Winston. Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids[J]. Anaerobe, 2017, 45: Pages 86-100. DOI: 10.1016/j.anaerobe.2017.03.004
[2] D. QIAO. Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation.[J]. Carcinogenesis, 2001, 22 6 1: 957-964. DOI: 10.1093/carcin/22.6.957
[3] HONG LIN. Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model[J]. Journal of Agricultural and Food Chemistry, 2019, 67 13: 3624-3632. DOI: 10.1021/acs.jafc.9b00249
[4] EKKEHARD BAYERD?RFFER . Increased serum deoxycholic acid levels in men with colorectal adenomas[J]. Gastroenterology, 1993, 104 1: Pages 145-151. DOI: 10.1016/0016-5085(93)90846-5

DEOXYCHOLIC-2,2,4,4-D4 ACID Preparation Products And Raw materials

Raw materials

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DEOXYCHOLIC-2,2,4,4-D4 ACID Suppliers

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112076-61-6, DEOXYCHOLIC-2,2,4,4-D4 ACIDRelated Search:

GLYCODEOXYCHOLIC ACID Deoxycholic acid Sodium deoxycholate DEOXYCHOLIC-2,2,4,4-D4 ACID OCTADECANOIC-12-D1 ACID CHOLIC-2,2,4,4-D4 ACID HEXADECANOIC-12-D1 ACID TETRADECANOIC-12-D1 ACID HEXADECANOIC-13,13-D2 ACID LITHOCHOLIC-2,2,4,4-D4 ACID

DEOXYCHOLIC-2,2,4,4-D4 ACID

Deoxycholic acid-2,2,4,4-d4

Deoxycholic-d4 Acid

Deoxycholic acid-D

Deoxycholic Acid-[d4] (Solution)

DEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL

Deoxycholic Acid-d4 MaxSpec? Standard

2H4]-Deoxycholic acid

Deoxycholic-2,2,4,4-d4 Acid/Deoxycholic acid-d4

DEOXYCHOLICACID(2,2,4,4-D4) IN METHANOL

Deoxycholic Acid-[d4] in Methanol

Deoxycholic acid-2,2,4,4-d<sub>4</sub>

D4-Deoxycholic Acid

Deoxycholic acid (2,2,4,4-D?, 98%) 100 μg/mL in methanol

Deoxycholic acid (2,2,4,4-D?, 98%)

112076-61-6

Steroids & Hormones - 13C & 2H

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Labeled Bioactive Compounds

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