2,5-Dioxopyrrolidin-1-yl octanoate

Product Name: 2,5-Dioxopyrrolidin-1-yl octanoate
CAS No.: 14464-30-3
Chemical Name: 2,5-Dioxopyrrolidin-1-yl octanoate
Synonyms: Eliglustat Impurity 11;Eliglustat intermediate 6;Octanoic acid-N-succinimidyl ester;2,5-dioxopyrrolidin-1-yl octanoate;1-(Octanoyloxy)-2,5-pyrrolidinedione;Caprylic acid-N-hydroxysuccinimide ester;Octanoic acid N-hydroxy succinimide ester;Octanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester;N-(Octanoyloxy)succinimide, N-Succinimidyl caprylate, N-Succinimidyl octanoate
CBNumber: CB9497580
Molecular Formula: C12H19NO4
Formula Weight: 241.28
MOL File: 14464-30-3.mol

More

Less

2,5-Dioxopyrrolidin-1-yl octanoate Property

Melting point:: 61-63 °C
Boiling point:: 333.2±25.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C

More

Less

Safety

Safety Statements: 22-24/25

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: D487145
Product name: (2,5-Dioxopyrrolidin-1-yl)Octanoate
Packaging: 250mg
Price: $40
Updated: 2021/12/16

Matrix Scientific

Product number: 178726
Product name: Caprylic acid N-succinimidyl ester
Packaging: 10g
Price: $1156
Updated: 2021/12/16

Matrix Scientific

Product number: 178726
Product name: Caprylic acid N-succinimidyl ester
Packaging: 25g
Price: $1980
Updated: 2021/12/16

Ambeed

Product number: A386850
Product name: 2,5-Dioxopyrrolidin-1-yloctanoate
Purity: 97%
Packaging: 250mg
Price: $10
Updated: 2021/12/16

Ambeed

Product number: A386850
Product name: 2,5-Dioxopyrrolidin-1-yloctanoate
Purity: 97%
Packaging: 1g
Price: $17
Updated: 2021/12/16

More

Less

2,5-Dioxopyrrolidin-1-yl octanoate Chemical Properties,Usage,Production

Uses

(2,5-Dioxopyrrolidin-1-yl) Octanoate is used in preparation of eliglustat and tartrate thereof.

Preparation

N-hydroxysuccinimide (Aldrich, 20.0 g, 173 mmol) and triethyl amine (29 mL, 208 mmol) were dissolved in methylene chloride in an ice bath under nitrogen. Octanoyl chloride (Aldrich, 35 mL, 205 mmol) was added dropwise over a period of 0.5 hours. The ice bath was then removed, and the resulting solution containing a white solid was stirred for 1 hour at room temperature. The white solid was separated by filtration, and the filtrate was subsequently washed with water (100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was then dried using sodium sulfate, filtered, and heptane (100 mL) was added. The resulting solution was subjected to rotoevaporation to remove most of the methylene chloride, resulting in the formation of a colorless to white flaky precipitate in heptane. The precipitate was filtered and washed with heptane. After drying, 2,5-Dioxopyrrolidin-1-yl octanoate was obtained in a yield of 84%.

2,5-Dioxopyrrolidin-1-yl octanoate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2,5-Dioxopyrrolidin-1-yl octanoate Suppliers

Canada 1 CHINA 65 Germany 2 India 1 Switzerland 1 United Kingdom 1 United States 4 Global 75

Yantai Sheng Kai Lun Biological Products Co. , Ltd.

Tel: 3119594100
Email: mark@sklnchem.cn
Country: China
ProdList: 7111
Advantage: 58

Suzhouhongxiong

Tel: 18051745768 18051745768
Email: Suzhouhongxiong@163.com
Country: China
ProdList: 100
Advantage: 58

Creasyn Finechem(Tianjin) Co., Ltd.

Tel: 022-022-83946278 13820372920
Fax: 022-83945176
Email: sales@creasyn.com
Country: China
ProdList: 994
Advantage: 68

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

DONGSHENG CHIRAL PHARMA

Tel: 180000000
Email: 3755454181@qq.com
Country: China
ProdList: 419
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

Tianjin Olefin Pharmaceutical Co., Ltd.

Tel: 18202662021
Fax: 022-25541300
Email: 2211422945@qq.com
Country: China
ProdList: 270
Advantage: 56

Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd.

Tel: 19943855286
Fax: 0371-53392065
Email: Trizpharm@aliyun.com
Country: China
ProdList: 1869
Advantage: 56

Hangzhou J&H Chemical Co., Ltd.

Tel: +86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 10015
Advantage: 53

Zhengzhou kangnuochenrui Chemical Technology Co.,Ltd

Tel: 18210788515
Fax: 18210788515
Email: zhuzixin999@163.c0m
Country: China
ProdList: 2948
Advantage: 55

More

Less

View Lastest Price from 2,5-Dioxopyrrolidin-1-yl octanoate manufacturers

R&D Scientific Inc.

Product: 2,5-dioxopyrrolidin-1-yl octanoate 14464-30-3
Price: US $900.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-02-10

Career Henan Chemical Co

Product: CAPRYLIC ACID N-SUCCINIMIDYL ESTER 14464-30-3
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

14464-30-3, 2,5-Dioxopyrrolidin-1-yl octanoateRelated Search:

Diethyl bromodifluoromethanephosphonate DISUCCINIMIDYL SUBERATE N-SUCCINIMIDYL PALMITATE Stearic acid-N-hydroxysuccinimide ester LAURIC ACID N-HYDROXY-SUCCINIMIDE ESTER N-Succinimidyl 11-(maleimido)undecanoate BS3 Sulfo-NHS-Biotin BIOTIN-NHS N-SUCCINIMIDYL 8-MALEIMIDOCAPRYLATE 2-IMINOBIOTIN N-HYDROXYSUCCINIMIDE ESTER BOC-L-CYCLOHEXYLALANINE HYDROXYSUCCINIMIDE ESTER DISUCCINIMIDYL SEBACATE 2,5-Dioxopyrrolidin-1-yl octanoate Disuccinimidyl dodecanoate Succinimidyl Myristate Sulfo-Kmus OLEIC ACID N-HYDROXYSUCCINIMIDE ESTER

Octanoic acid-N-succinimidyl ester

Caprylic acid-N-hydroxysuccinimide ester

N-(Octanoyloxy)succinimide, N-Succinimidyl caprylate, N-Succinimidyl octanoate

Eliglustat intermediate 6

2,5-dioxopyrrolidin-1-yl octanoate

1-(Octanoyloxy)-2,5-pyrrolidinedione

Octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Octanoic acid, 2,5-dioxo-1-pyrrolidinyl ester

Eliglustat Impurity 11

Octanoic acid N-hydroxy succinimide ester

14464-30-3