ChemicalBook > CAS DataBase List > 2,5-Dioxopyrrolidin-1-yl octanoate

2,5-Dioxopyrrolidin-1-yl octanoate

Product Name: 2,5-Dioxopyrrolidin-1-yl octanoate
CAS No.: 14464-30-3
Chemical Name: 2,5-Dioxopyrrolidin-1-yl octanoate
Synonyms: Eliglustat Impurity 11;Eliglustat intermediate 6;Octanoic acid-N-succinimidyl ester;2,5-dioxopyrrolidin-1-yl octanoate;1-(Octanoyloxy)-2,5-pyrrolidinedione;Caprylic acid-N-hydroxysuccinimide ester;Octanoic acid N-hydroxy succinimide ester;Octanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester;N-(Octanoyloxy)succinimide, N-Succinimidyl caprylate, N-Succinimidyl octanoate
CBNumber: CB9497580
Molecular Formula: C12H19NO4
Formula Weight: 241.28
MOL File: 14464-30-3.mol

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2,5-Dioxopyrrolidin-1-yl octanoate Property

Melting point:: 61-63 °C
Boiling point:: 333.2±25.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
Appearance: White to off-white Solid
InChI: InChI=1S/C12H19NO4/c1-2-3-4-5-6-7-12(16)17-13-10(14)8-9-11(13)15/h2-9H2,1H3
InChIKey: PEJVSXYBFAVPAQ-UHFFFAOYSA-N
SMILES: C(ON1C(=O)CCC1=O)(=O)CCCCCCC

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Safety

Safety Statements: 22-24/25

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D487145
Product name: (2,5-Dioxopyrrolidin-1-yl)Octanoate
Packaging: 250mg
Price: $40
Updated: 2021/12/16

Matrix Scientific

Product number: 178726
Product name: Caprylic acid N-succinimidyl ester
Packaging: 10g
Price: $1156
Updated: 2021/12/16

Matrix Scientific

Product number: 178726
Product name: Caprylic acid N-succinimidyl ester
Packaging: 25g
Price: $1980
Updated: 2021/12/16

Ambeed

Product number: A386850
Product name: 2,5-Dioxopyrrolidin-1-yloctanoate
Purity: 97%
Packaging: 250mg
Price: $10
Updated: 2021/12/16

Ambeed

Product number: A386850
Product name: 2,5-Dioxopyrrolidin-1-yloctanoate
Purity: 97%
Packaging: 1g
Price: $17
Updated: 2021/12/16

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2,5-Dioxopyrrolidin-1-yl octanoate Chemical Properties,Usage,Production

Uses

(2,5-Dioxopyrrolidin-1-yl) Octanoate is used in preparation of eliglustat and tartrate thereof.

Preparation

N-hydroxysuccinimide (Aldrich, 20.0 g, 173 mmol) and triethyl amine (29 mL, 208 mmol) were dissolved in methylene chloride in an ice bath under nitrogen. Octanoyl chloride (Aldrich, 35 mL, 205 mmol) was added dropwise over a period of 0.5 hours. The ice bath was then removed, and the resulting solution containing a white solid was stirred for 1 hour at room temperature. The white solid was separated by filtration, and the filtrate was subsequently washed with water (100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was then dried using sodium sulfate, filtered, and heptane (100 mL) was added. The resulting solution was subjected to rotoevaporation to remove most of the methylene chloride, resulting in the formation of a colorless to white flaky precipitate in heptane. The precipitate was filtered and washed with heptane. After drying, 2,5-Dioxopyrrolidin-1-yl octanoate was obtained in a yield of 84%.

2,5-Dioxopyrrolidin-1-yl octanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,5-Dioxopyrrolidin-1-yl octanoate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,5-Dioxopyrrolidin-1-yl octanoate 14464-30-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-25

R&D Scientific Inc.

Product: 2,5-dioxopyrrolidin-1-yl octanoate 14464-30-3
Price: US $900.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-02-10

Career Henan Chemical Co

Product: CAPRYLIC ACID N-SUCCINIMIDYL ESTER 14464-30-3
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

14464-30-3, 2,5-Dioxopyrrolidin-1-yl octanoateRelated Search:

Diethyl bromodifluoromethanephosphonate DISUCCINIMIDYL SUBERATE N-SUCCINIMIDYL PALMITATE Stearic acid-N-hydroxysuccinimide ester LAURIC ACID N-HYDROXY-SUCCINIMIDE ESTER N-Succinimidyl 11-(maleimido)undecanoate BS3 Sulfo-NHS-Biotin BIOTIN-NHS N-SUCCINIMIDYL 8-MALEIMIDOCAPRYLATE 2-IMINOBIOTIN N-HYDROXYSUCCINIMIDE ESTER BOC-L-CYCLOHEXYLALANINE HYDROXYSUCCINIMIDE ESTER DISUCCINIMIDYL SEBACATE 2,5-Dioxopyrrolidin-1-yl octanoate Disuccinimidyl dodecanoate Succinimidyl Myristate Sulfo-Kmus OLEIC ACID N-HYDROXYSUCCINIMIDE ESTER

Octanoic acid-N-succinimidyl ester

Caprylic acid-N-hydroxysuccinimide ester

N-(Octanoyloxy)succinimide, N-Succinimidyl caprylate, N-Succinimidyl octanoate

Eliglustat intermediate 6

2,5-dioxopyrrolidin-1-yl octanoate

1-(Octanoyloxy)-2,5-pyrrolidinedione

Octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Octanoic acid, 2,5-dioxo-1-pyrrolidinyl ester

Eliglustat Impurity 11

Octanoic acid N-hydroxy succinimide ester

14464-30-3