ChemicalBook > CAS DataBase List > 2,5-Dioxopyrrolidin-1-yl octanoate

2,5-Dioxopyrrolidin-1-yl octanoate

Product Name
2,5-Dioxopyrrolidin-1-yl octanoate
CAS No.
14464-30-3
Chemical Name
2,5-Dioxopyrrolidin-1-yl octanoate
Synonyms
Eliglustat Impurity 11;Eliglustat intermediate 6;Octanoic acid-N-succinimidyl ester;2,5-dioxopyrrolidin-1-yl octanoate;1-(Octanoyloxy)-2,5-pyrrolidinedione;Caprylic acid-N-hydroxysuccinimide ester;Octanoic acid N-hydroxy succinimide ester;Octanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester;N-(Octanoyloxy)succinimide, N-Succinimidyl caprylate, N-Succinimidyl octanoate
CBNumber
CB9497580
Molecular Formula
C12H19NO4
Formula Weight
241.28
MOL File
14464-30-3.mol
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2,5-Dioxopyrrolidin-1-yl octanoate Property

Melting point:
61-63 °C
Boiling point:
333.2±25.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
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Safety

Safety Statements 
22-24/25
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D487145
Product name
(2,5-Dioxopyrrolidin-1-yl)Octanoate
Packaging
250mg
Price
$40
Updated
2021/12/16
Matrix Scientific
Product number
178726
Product name
Caprylic acid N-succinimidyl ester
Packaging
10g
Price
$1156
Updated
2021/12/16
Matrix Scientific
Product number
178726
Product name
Caprylic acid N-succinimidyl ester
Packaging
25g
Price
$1980
Updated
2021/12/16
Ambeed
Product number
A386850
Product name
2,5-Dioxopyrrolidin-1-yloctanoate
Purity
97%
Packaging
250mg
Price
$10
Updated
2021/12/16
Ambeed
Product number
A386850
Product name
2,5-Dioxopyrrolidin-1-yloctanoate
Purity
97%
Packaging
1g
Price
$17
Updated
2021/12/16
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2,5-Dioxopyrrolidin-1-yl octanoate Chemical Properties,Usage,Production

Uses

(2,5-Dioxopyrrolidin-1-yl) Octanoate is used in preparation of eliglustat and tartrate thereof.

Preparation

N-hydroxysuccinimide (Aldrich, 20.0 g, 173 mmol) and triethyl amine (29 mL, 208 mmol) were dissolved in methylene chloride in an ice bath under nitrogen. Octanoyl chloride (Aldrich, 35 mL, 205 mmol) was added dropwise over a period of 0.5 hours. The ice bath was then removed, and the resulting solution containing a white solid was stirred for 1 hour at room temperature. The white solid was separated by filtration, and the filtrate was subsequently washed with water (100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was then dried using sodium sulfate, filtered, and heptane (100 mL) was added. The resulting solution was subjected to rotoevaporation to remove most of the methylene chloride, resulting in the formation of a colorless to white flaky precipitate in heptane. The precipitate was filtered and washed with heptane. After drying, 2,5-Dioxopyrrolidin-1-yl octanoate was obtained in a yield of 84%.

2,5-Dioxopyrrolidin-1-yl octanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-Dioxopyrrolidin-1-yl octanoate Suppliers

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View Lastest Price from 2,5-Dioxopyrrolidin-1-yl octanoate manufacturers

R&D Scientific Inc.
Product
2,5-dioxopyrrolidin-1-yl octanoate 14464-30-3
Price
US $900.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-02-10
Career Henan Chemical Co
Product
CAPRYLIC ACID N-SUCCINIMIDYL ESTER 14464-30-3
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

14464-30-3, 2,5-Dioxopyrrolidin-1-yl octanoateRelated Search:

Diethyl bromodifluoromethanephosphonate DISUCCINIMIDYL SUBERATE N-SUCCINIMIDYL PALMITATE Stearic acid-N-hydroxysuccinimide ester LAURIC ACID N-HYDROXY-SUCCINIMIDE ESTER N-Succinimidyl 11-(maleimido)undecanoate BS3 Sulfo-NHS-Biotin BIOTIN-NHS N-SUCCINIMIDYL 8-MALEIMIDOCAPRYLATE 2-IMINOBIOTIN N-HYDROXYSUCCINIMIDE ESTER BOC-L-CYCLOHEXYLALANINE HYDROXYSUCCINIMIDE ESTER DISUCCINIMIDYL SEBACATE 2,5-Dioxopyrrolidin-1-yl octanoate Disuccinimidyl dodecanoate Succinimidyl Myristate Sulfo-Kmus OLEIC ACID N-HYDROXYSUCCINIMIDE ESTER

  • Octanoic acid-N-succinimidyl ester
  • Caprylic acid-N-hydroxysuccinimide ester
  • N-(Octanoyloxy)succinimide, N-Succinimidyl caprylate, N-Succinimidyl octanoate
  • Eliglustat intermediate 6
  • 2,5-dioxopyrrolidin-1-yl octanoate
  • 1-(Octanoyloxy)-2,5-pyrrolidinedione
  • Octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester
  • Octanoic acid, 2,5-dioxo-1-pyrrolidinyl ester
  • Eliglustat Impurity 11
  • Octanoic acid N-hydroxy succinimide ester
  • 14464-30-3