ChemicalBook > CAS DataBase List > Bepridil hydrochloride

Bepridil hydrochloride

Product Name
Bepridil hydrochloride
CAS No.
74764-40-2
Chemical Name
Bepridil hydrochloride
Synonyms
angopril;Unii-4W2p15D93m;Bepridil hydrochloride;UEECHQPWQHYEDE-UHFFFAOYSA-N;Bepridil hydrochloride salt;Bepridil hydrochloride hydrate;Bepridil hydrochloride USP/EP/BP;l)-,monohydrochloride,monohydrate;1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride;N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)anilinehydrochloride
CBNumber
CB9497924
Molecular Formula
C24H37ClN2O2
Formula Weight
421.01578
MOL File
74764-40-2.mol
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Bepridil hydrochloride Property

Melting point:
91 ±2°
storage temp. 
Desiccate at RT
solubility 
Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml)
form 
powder
color 
white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
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Safety

WGK Germany 
2
RTECS 
UY1162000
Toxicity
LD50 in mice (mg/kg): 1955 orally, 23.5 i.v. (Mauvernay, 1978)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H332Harmful if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B5016
Product name
Bepridil hydrochloride
Purity
powder
Packaging
100mg
Price
$208
Updated
2022/05/15
Tocris
Product number
4117
Product name
Bepridil hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$106
Updated
2021/12/16
Usbiological
Product number
254738
Product name
Bepridil hydrochloride
Packaging
50mg
Price
$339
Updated
2021/12/16
ChemScene
Product number
CS-0013009
Product name
Bepridil(hydrochloridehydrate)
Purity
99.70%
Packaging
25mg
Price
$220
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148396
Product name
Bepridil hydrochloride
Packaging
100mg
Price
$315
Updated
2021/12/16
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Bepridil hydrochloride Chemical Properties,Usage,Production

Description

Bepridil (74764-40-2) is a clinically useful calcium channel blocker with antianginal activity.1 It has recently been shown to possess potent activity against SARS-CoV-2 in vitro.2 Bepridil was also able to provide protection from Ebola virus3 and other filoviruses in a mouse model4.

Uses

antineoplastic, alkylating agent

Uses

Bepridil Hydrochloride is a calcium channel blocker. It also activates mitochondrial ATP-sensitive KATP channelsBepridil Hydrochloride is an antiarrhythmic and antihypertensive agent and used for treating atrial fibrillation.

Definition

ChEBI: The hydrochloride monohydrate of bepridril.

brand name

Bepadin (Medpointe); Vascor (Johnson & Johnson).

General Description

Bepridil hydrochloride,β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethylamine hydrochloride (Vascor), is a secondgenerationalkylamine-type channel blocker, structurallyunrelated to the dihydropyridines. Its actions are less specificthan those of the three prototypical channel blockers,verapamil, diltiazem, and nifedipine. In addition to being aCa2+ channel blocker, it inhibits sodium flow into the hearttissue and lengthens cardiac repolarization, causing bradycardia.Caution should be used if it is given to a patient withhypokalemia. Bepridil hydrochloride is used for stableangina. The drug has a half-life of 33 hours and is highlybound to protein (99%).

Hazard

Moderately toxic by ingestion.

Biochem/physiol Actions

Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na+-Ca2+ exchange; inhibits growth of brain tumor cells in vitro.

Mechanism of action

In addition to class IV effects, bepridil also shows class I effects. The substance is active against both supraventricular and ventricular arrhythmias , .

References

Hollingshead et al. (1992), A review of its pharmacological properties and therapeutic use in stable angina pectoris; Drugs, 44 835 Vatansever et al. (2021), Bepridil is potent against SARS-CoV-2 in vitro; Proc. Natl. Acad. Sci USA, 118 e2012201118 Johansen et al. (2015), A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity; Sci. Transl. Med., 7 290ra89 DeWald et al. (2018), The calcium channel blocker bepridil demonstrates efficacy in the murine model of marburg virus disease; J. Infect. Dis., 218(suppl 5) S588

Bepridil hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

BEPRIDIL
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Bepridil hydrochloride Suppliers

China 44 Germany 2 Switzerland 1 United Kingdom 2 United States 12 Global 61
3B Pharmachem (Wuhan) International Co.,Ltd.
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View Lastest Price from Bepridil hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Bepridil hydrochloride 74764-40-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-11

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  • 74764-40-2
  • C24H35N2OHCl
  • C24H34N2OHCl
  • C24H35ClN2OH2O
  • GLIADEL
  • API