Bepridil hydrochloride
- Product Name
- Bepridil hydrochloride
- CAS No.
- 74764-40-2
- Chemical Name
- Bepridil hydrochloride
- Synonyms
- angopril;Unii-4W2p15D93m;Bepridil hydrochloride;UEECHQPWQHYEDE-UHFFFAOYSA-N;Bepridil hydrochloride salt;Bepridil hydrochloride hydrate;Bepridil hydrochloride USP/EP/BP;l)-,monohydrochloride,monohydrate;1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride;N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)anilinehydrochloride
- CBNumber
- CB9497924
- Molecular Formula
- C24H37ClN2O2
- Formula Weight
- 421.01578
- MOL File
- 74764-40-2.mol
Bepridil hydrochloride Property
- Melting point:
- 91 ±2°
- storage temp.
- Desiccate at RT
- solubility
- Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml)
- form
- powder
- color
- white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety
- WGK Germany
- 2
- RTECS
- UY1162000
- Toxicity
- LD50 in mice (mg/kg): 1955 orally, 23.5 i.v. (Mauvernay, 1978)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B5016
- Product name
- Bepridil hydrochloride
- Purity
- powder
- Packaging
- 100mg
- Price
- $208
- Updated
- 2022/05/15
- Product number
- 4117
- Product name
- Bepridil hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $106
- Updated
- 2021/12/16
- Product number
- 254738
- Product name
- Bepridil hydrochloride
- Packaging
- 50mg
- Price
- $339
- Updated
- 2021/12/16
- Product number
- CS-0013009
- Product name
- Bepridil(hydrochloridehydrate)
- Purity
- 99.70%
- Packaging
- 25mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FB148396
- Product name
- Bepridil hydrochloride
- Packaging
- 100mg
- Price
- $315
- Updated
- 2021/12/16
Bepridil hydrochloride Chemical Properties,Usage,Production
Description
Bepridil (74764-40-2) is a clinically useful calcium channel blocker with antianginal activity.1 It has recently been shown to possess potent activity against SARS-CoV-2 in vitro.2 Bepridil was also able to provide protection from Ebola virus3 and other filoviruses in a mouse model4.
Uses
antineoplastic, alkylating agent
Uses
Bepridil Hydrochloride is a calcium channel blocker. It also activates mitochondrial ATP-sensitive KATP channelsBepridil Hydrochloride is an antiarrhythmic and antihypertensive agent and used for treating atrial fibrillation.
Definition
ChEBI: The hydrochloride monohydrate of bepridril.
brand name
Bepadin (Medpointe); Vascor (Johnson & Johnson).
General Description
Bepridil hydrochloride,β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethylamine hydrochloride (Vascor), is a secondgenerationalkylamine-type channel blocker, structurallyunrelated to the dihydropyridines. Its actions are less specificthan those of the three prototypical channel blockers,verapamil, diltiazem, and nifedipine. In addition to being aCa2+ channel blocker, it inhibits sodium flow into the hearttissue and lengthens cardiac repolarization, causing bradycardia.Caution should be used if it is given to a patient withhypokalemia. Bepridil hydrochloride is used for stableangina. The drug has a half-life of 33 hours and is highlybound to protein (99%).
Hazard
Moderately toxic by ingestion.
Biochem/physiol Actions
Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na+-Ca2+ exchange; inhibits growth of brain tumor cells in vitro.
Mechanism of action
In addition to class IV effects, bepridil also shows class I effects. The substance is active against both supraventricular and ventricular arrhythmias , .
References
Hollingshead et al. (1992), A review of its pharmacological properties and therapeutic use in stable angina pectoris; Drugs, 44 835 Vatansever et al. (2021), Bepridil is potent against SARS-CoV-2 in vitro; Proc. Natl. Acad. Sci USA, 118 e2012201118 Johansen et al. (2015), A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity; Sci. Transl. Med., 7 290ra89 DeWald et al. (2018), The calcium channel blocker bepridil demonstrates efficacy in the murine model of marburg virus disease; J. Infect. Dis., 218(suppl 5) S588
Bepridil hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Bepridil hydrochloride manufacturers
- Product
- Bepridil hydrochloride 74764-40-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-11