(D-ALA2)-LEUCINE ENKEPHALIN-ARG

Product Name: (D-ALA2)-LEUCINE ENKEPHALIN-ARG
CAS No.: 81733-79-1
Chemical Name: (D-ALA2)-LEUCINE ENKEPHALIN-ARG
Synonyms: cyl)-;inine;Tageflar;Brn 4287455;Enkephalin-Arg [D-Ala2]-Leu;ala(2)-arg(6)-enkephalin-le;Tyr-D-Ala-Gly-Phe-Leu-Arg-OH;enkephalin-Leu, Ala(2)-Arg(6)-;(D-ALA2)-LEUCINE ENKEPHALIN-ARG;L-Tyr-D-Ala-Gly-L-Phe-L-Leu-L-Arg-OH
CBNumber: CB9498082
Molecular Formula: C35H51N9O8
Formula Weight: 725.83
MOL File: 81733-79-1.mol

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(D-ALA2)-LEUCINE ENKEPHALIN-ARG Property

Density: 1.36±0.1 g/cm3(Predicted)
pka: 3.34±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: E3220-20P
Product name: Enkephalin-Arg [D-Ala2]-Leu
Packaging: 25mg
Price: $396
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002205
Product name: DALARGIN
Purity: 95.00%
Packaging: 5MG
Price: $617.46
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA108952
Product name: (D-Ala2)-Leu-Enkephalin-Arg trifluoroacetate salt H-Tyr-D-Ala-Gly-Phe-Leu-Arg-OH trifluoroacetate salt
Packaging: 100mg
Price: $685
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002205
Product name: DALARGIN
Purity: 95.00%
Packaging: 25MG
Price: $739.78
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002205
Product name: DALARGIN
Purity: 95.00%
Packaging: 100MG
Price: $1127.86
Updated: 2021/12/16

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(D-ALA2)-LEUCINE ENKEPHALIN-ARG Chemical Properties,Usage,Production

Uses

Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin (HY-A0276)-induced cell death. Dalargin shows nephroprotective effects on Gentamicin-induced kidney injury. Dalargin shows antiulcer activity[1][2][3].

in vivo

Dalargin (25, 50 μg/kg; i.p.) shows nephroprotective effects on gentamicin-induced kidney injury in rats^[2].

Animal Model:	290-350 g, White male rats^[2]
Dosage:	25, 50 μg/kg
Administration:	I.p. (3 h before each gentamicin injection)
Result:	Mitigated gentamicin-induced acutekidney injury, attenuated ROS generation and oxidative stress, alleviated histopathological changes in a renal tissue.

IC 50

δ Opioid Receptor/DOR

References

[1] Titov MI, et al. Dalargin--a peptidny? preparat s tsitoprotektivnym de?stviem [Dalargin--a peptide preparation with cytoprotective action]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1985;8(2):72-6. PMID:2998416
[2] Plotnikov EY, et al. Nephroprotective effect of GSK-3β inhibition by lithium ions and δ-opioid receptor agonist dalargin on gentamicin-induced nephrotoxicity. Toxicol Lett. 2013 Jul 18;220(3):303-8. DOI:10.1016/j.toxlet.2013.04.023
[3] Polonski? VM, et al. Mesto prilozheniia (tsentral'noe ili perifericheskoe) protivoiazvennogo de?stviia sinteticheskogo analoga éndogennykh opioidov dalargina v éksperimental'no? modeli tsisteaminovykh duodenal'nykh iazv u krys [The site (central or peripheral) of the anti-ulcer action of dalargin, a synthetic analog of endogenous opioids in an experimental model of cysteamine-induced duodenal ulcer in rats]. Biull Eksp Biol Med. 1987 Apr;103(4):433-4. PMID:3032303

(D-ALA2)-LEUCINE ENKEPHALIN-ARG Preparation Products And Raw materials

Raw materials

Preparation Products

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(D-ALA2)-LEUCINE ENKEPHALIN-ARG Suppliers

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View Lastest Price from (D-ALA2)-LEUCINE ENKEPHALIN-ARG manufacturers

Career Henan Chemical Co

Product: (D-ALA2)-LEUCINE ENKEPHALIN-ARG 81733-79-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-08-08

81733-79-1, (D-ALA2)-LEUCINE ENKEPHALIN-ARGRelated Search:

Aviptadil Antide Dynorphin A (1-13) DSIP TYR-D-ALA-GLY-PHE-LEU TYR-D-ALA-GLY-PHE-LEU-NH2 ACETATE SALT LEU-ENKEPHALIN-ARG H-LEU-ARG-OH (D-ALA2)-LEUCINE ENKEPHALIN-ARG

(D-Ala2)-Leu-Enkephalin-Arg trifluoroacetate salt H-Tyr-D-Ala-Gly-Phe-Leu-Arg-OH trifluoroacetate salt

L-Tyr-D-Ala-Gly-L-Phe-L-Leu-L-Arg-OH

Tyr-D-Ala-Gly-Phe-Leu-Arg-OH

1-6-beta-Neoendorphin (human), 2-D-alanine-

2-D-Alanine-1-6-beta-neoendorphin (human)

Brn 4287455

L-Arginine, N(sup 2)-(N-(N-(N-(L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-L-leucyl)-

N(Sup 2)-(N-(N-(N-(L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginine

Tageflar

Dalargin,(D-Ala2)-Leu-Enkephalin-Arg

(D-Ala2)-Leu-Enkephalin-Arg, Dalargin

DALARGIN Enkephalin-Arg [D-Ala2]-Leu

Enkephalin-Arg [D-Ala2]-Leu

(D-ALA2)-LEUCINE ENKEPHALIN-ARG

ala(2)-arg(6)-enkephalin-le

cyl)-

inine

l-arginine,n(sup2)-(n-(n-(n-(l-tyrosyl-d-alanyl)glycyl)-l-phenylalanyl)-l-leu

n(sup2)-(n-(n-(n-(l-tyrosyl-d-alanyl)glycyl)-l-phenylalanyl)-l-leucyl)-l-arg

tyrosyl-d-alanyl-glycyl-phenylalanyl-leucyl-arginine

enkephalin-Leu, Ala(2)-Arg(6)-

(D-alanine2)leucine enkephalin arginine

L-Arginine, L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucyl-

(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid

(D-Ala2)-Leu-Enkephalin-Arg acetate salt

(D-Ala?)-Leu-Enkephalin-Arg trifluoroacetate salt

81733-79-1

C35H51N9O8