(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
- Product Name
- (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
- CAS No.
- 133812-16-5
- Chemical Name
- (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
- Synonyms
- Locostatin;(E/Z)-Locostatin;Locostatin, 10 mM in DMSO;4-benzyl-3-crotonyl-2-oxazolidinone;(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&;Cell Sheet Migration Inhibitor, Locostatin;(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one;(S,E)-4-benzyl-3-(but-2-enoyl)oxazolidin-2-one, 98%;2-Oxazolidinone, 3-(1-oxo-2-buten-1-yl)-4-(phenylmethyl)-, (4S)-
- CBNumber
- CB9499650
- Molecular Formula
- C14H15NO3
- Formula Weight
- 245.27
- MOL File
- 133812-16-5.mol
(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Property
- Melting point:
- 84-88 °C(lit.)
- Boiling point:
- 351.0±25.0 °C(Predicted)
- Density
- 1.205±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (60 mg/ml)
- form
- solid
- pka
- -1?+-.0.40(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29092
- Product name
- (E/Z)-Locostatin
- Packaging
- 10mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 29092
- Product name
- (E/Z)-Locostatin
- Packaging
- 100mg
- Price
- $595
- Updated
- 2024/03/01
- Product number
- 29092
- Product name
- (E/Z)-Locostatin
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 29092
- Product name
- (E/Z)-Locostatin
- Packaging
- 50mg
- Price
- $330
- Updated
- 2024/03/01
- Product number
- C256503
- Product name
- CellSheetMigrationInhibitor,Locostatin
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Chemical Properties,Usage,Production
Description
Locostatin (133812-16-5) inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3? Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5
Uses
Locostatin is a cell permeable, potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration
References
[1] SHOUTIAN ZHU. A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration.[J]. Chemistry & biology, 2005, 12 9: 981-991. DOI:10.1016/j.chembiol.2005.07.007
[2] ANWAR B BESHIR. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket.[J]. Forum on immunopathological diseases and therapeutics, 2011, 2 1: 47-58. DOI:10.1615/forumimmundisther.v2.i1.60
[3] ANTOINE MÉNORET. The oxazolidinone derivative locostatin induces cytokine appeasement.[J]. Journal of immunology, 2009, 183 11: 7489-7496. DOI:10.4049/jimmunol.0901414
[4] JUNJI MA. Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice.[J]. Digestive Diseases and Sciences, 2019: 2570-2580. DOI:10.1007/s10620-019-05588-5
[5] KEVIN T. MC HENRY. Raf kinase inhibitor protein positively regulates cell–substratum adhesion while negatively regulating cell–cell adhesion[J]. Journal of cellular biochemistry, 2007, 103 3: 972-985. DOI:10.1002/jcb.21470
(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& manufacturers
- Product
- (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& 133812-16-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01