(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&

Product Name: (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
CAS No.: 133812-16-5
Chemical Name: (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
Synonyms: Locostatin;(E/Z)-Locostatin;4-benzyl-3-crotonyl-2-oxazolidinone;(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&;Cell Sheet Migration Inhibitor, Locostatin;(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one;(S,E)-4-benzyl-3-(but-2-enoyl)oxazolidin-2-one, 98%;2-Oxazolidinone, 3-(1-oxo-2-buten-1-yl)-4-(phenylmethyl)-, (4S)-
CBNumber: CB9499650
Molecular Formula: C14H15NO3
Formula Weight: 245.27
MOL File: 133812-16-5.mol

More

Less

(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Property

Melting point:: 84-88 °C(lit.)
Boiling point:: 351.0±25.0 °C(Predicted)
Density: 1.205±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (60 mg/ml)
form: solid
pka: -1?+-.0.40(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Alfa Aesar

Product number: J64425
Product name: Locostatin
Packaging: 10mg
Price: $128.65
Updated: 2024/03/01

Alfa Aesar

Product number: J64425
Product name: Locostatin
Packaging: 50mg
Price: $390.65
Updated: 2024/03/01

Cayman Chemical

Product number: 29092
Product name: (E/Z)-Locostatin
Packaging: 10mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 29092
Product name: (E/Z)-Locostatin
Packaging: 100mg
Price: $595
Updated: 2024/03/01

Cayman Chemical

Product number: 29092
Product name: (E/Z)-Locostatin
Packaging: 5mg
Price: $62
Updated: 2024/03/01

More

Less

(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Chemical Properties,Usage,Production

Description

Locostatin (133812-16-5) inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3? Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5

Uses

Locostatin is a cell permeable, potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration

References

Zhu et al. (2005), A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration; Chem. Biol., 12 981 Beshir et al. (2011), Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket; For. Immunopathol. Dis. Therap. 2 47 Menoret et al. (2009), The oxazolidinone derivative locostatin induces cytokine appeasement; J. Immunol. 183 7489 Ma et al. (2019), Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice; Dig. Dis. Sci. 64 2570 Mc Henry et al. (2008), Raf kinase inhibitor protein positively regulates cell-cell adhesion; J. Cell Biochem. 103 972

(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Suppliers

China 39 India 3 Switzerland 1 United States 5 Global 48

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5738
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com
Country: China
ProdList: 16687
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Shijiazhuang Yesheng Chemical Technology Co., Ltd

Tel: 0311-68030586 18031147013
Fax: 0311-68030586
Email: yeshengchemical@163.com
Country: China
ProdList: 2976
Advantage: 58

Shanghai Pingguo Pharmaceutical Co., Ltd.

Tel: 021-20432229
Fax: QQ2412110556
Email: 2412110556@qq.com
Country: China
ProdList: 6018
Advantage: 55

Suzhou Kangrun Pharmaceutical Co., Ltd.

Tel: 0512-63912376 18962555590
Country: China
ProdList: 973
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
Advantage: 58

Binhai gill polypeptide co. LTD

Tel: 021-61263389 13524856427
Fax: WeChat630417570
Email: Joetang@glschina.com
Country: China
ProdList: 9618
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

More

Less

View Lastest Price from (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& manufacturers

Career Henan Chemical Co

Product: (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& 133812-16-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200g
Release date: 2020-02-01

133812-16-5, (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&Related Search:

Ibrutinib DO264 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Fruquintinib|HMPL-013

(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&

4-benzyl-3-crotonyl-2-oxazolidinone

Locostatin

(S,E)-4-benzyl-3-(but-2-enoyl)oxazolidin-2-one, 98%

(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one

Cell Sheet Migration Inhibitor, Locostatin

(E/Z)-Locostatin

2-Oxazolidinone, 3-(1-oxo-2-buten-1-yl)-4-(phenylmethyl)-, (4S)-

133812-16-5

S4Benzyl3crotonyl2oxazolidinone97