ChemicalBook > CAS DataBase List > (TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL

(TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL

Product Name
(TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL
CAS No.
102229-10-7
Chemical Name
(TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL
Synonyms
2-(tert-Butyldimethylsiloxy)ethanol;DK025;DK448;DKSI011;CB9511523;DKFELEX0097;2-(t-butyldimethylsiloxy)ethanol;2-tert-Butyldimethylsilyloxyethanol;(TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL;2-((tert-ButyldiMethylsilyl)oxy)etanol-
CBNumber
CB9511523
Molecular Formula
C8H20O2Si
Formula Weight
176.33
MOL File
102229-10-7.mol
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(TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL Property

Boiling point:
74-80℃ (17 Torr)
Density 
0.890
refractive index 
1.430
storage temp. 
2-8°C
solubility 
Dichloromethane (Slightly), Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate
form 
clear liquid
pka
14.38±0.10(Predicted)
Specific Gravity
0.8908
color 
Colorless to Almost colorless
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
Stability:
Acid Sensitive
InChI
InChI=1S/C8H20O2Si/c1-8(2,3)11(4,5)10-7-6-9/h9H,6-7H2,1-5H3
InChIKey
YJYAGNPMQVHYAH-UHFFFAOYSA-N
SMILES
C(O)CO[Si](C(C)(C)C)(C)C
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Safety

RIDADR 
1993
HazardClass 
3
PackingGroup 
Ⅲ
HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5851
Product name
2-[[tert-Butyl(dimethyl)silyl]oxy]ethanol
Packaging
25G
Price
$111
Updated
2025/07/31
TCI Chemical
Product number
B5851
Product name
2-[[tert-Butyl(dimethyl)silyl]oxy]ethanol
Packaging
100G
Price
$334
Updated
2025/07/31
TRC
Product number
B691470
Product name
2-tert-Butyldimethylsilyloxyethanol
Packaging
1g
Price
$110
Updated
2021/12/16
TRC
Product number
B691470
Product name
2-tert-Butyldimethylsilyloxyethanol
Packaging
25g
Price
$250
Updated
2021/12/16
Matrix Scientific
Product number
094435
Product name
2-((tert-Butyldimethylsilyl)oxy)ethanol
Purity
95+%
Packaging
1g
Price
$10
Updated
2021/12/16
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(TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL Chemical Properties,Usage,Production

Chemical Properties

Oil

Uses

(Tert.-Butyldimethylsilyloxy)Ethanol (also known as 2-((tert-Butyldimethylsilyl)oxy)ethanol) is used in organic synthesis to prepare other silane compounds.

Synthesis

107-21-1

18162-48-6

102229-10-7

A solution of anhydrous THF (100 mL) with ethylene glycol (20.0 g, 0.322 mol) was added slowly and dropwise to an anhydrous THF (500 mL) suspension of NaH (12.9 g, 0.322 mol, 60% dispersed in mineral oil). After stirring the reaction mixture for 1 h at room temperature, tert-butyldimethylchlorosilane (TBSCl, 48.59 g, 0.322 mol) was added and stirring was continued for 1 h at room temperature. Upon completion of the reaction, the reaction was quenched with 10% aqueous K2CO3 (100 mL) and subsequently extracted with methyl tert-butyl ether (MTBE, 3 x 300 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with gradient elution using a petroleum ether solution of 1% to 33% ethyl acetate to afford 2-((tert-butyldimethylmethylsilyl)oxy)ethanol (55.0 g, 96% yield) as a colorless oil.

References

[1] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 7, p. 2375 - 2385
[2] Organic Letters, 2016, vol. 18, # 18, p. 4534 - 4537
[3] Patent: US2016/122318, 2016, A1. Location in patent: Paragraph 0181
[4] Patent: WO2017/24018, 2017, A1. Location in patent: Paragraph 00131
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 9, p. 2157 - 2165

(TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL Suppliers

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View Lastest Price from (TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-[(tert-Butyldimethylsilyl)oxy]ethanol 102229-10-7
Price
US $1.10-9.90/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-18
Shaanxi Dideu New Materials Co. Ltd
Product
(TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL 102229-10-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
95.0%
Supply Ability
10000KGS
Release date
2025-07-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(t-butyldimethylsiloxy)ethanol 102229-10-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

102229-10-7, (TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOLRelated Search:

tert-Butylchlorodiphenylsilane ALLYL(CHLOROMETHYL)DIMETHYLSILANE CHLOROMETHYL(METHYL)DIMETHOXYSILANE TERT-BUTYLDIMETHYL(2-PROPYNYLOXY)SILANE tert-Butyl N-(3-aminopropyl)-N-methylcarbamate TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE TERT-BUTYL PROPIOLATE tert-Butyldiphenylsilane TERT-BUTYL-(2-IODO-ETHOXY)-DIMETHYL-SILANE 2-(N-Boc-aMinoMethyl)-5-chloropyridine 5-O-tert-Butyldiphenylsilyl-2,3-O-isopropylidene-D-ribofuranose DMT-2′O-TBDMS-rU Phosphoramidite DMT-2'O-TBDMS-rA(bz) Phosphoramidite 3,6-DI-O-(TERT-BUTYLDIMETHYLSILYL)-D-GLUCAL (2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine 3,4-DI-O-ACETYL-6-O-(TERT-BUTYLDIMETHYLSILYL)-D-GLUCAL 6,6'-DI-O-(TERT-BUTYLDIMETHYLSILYL)-D-LACTAL 6-O-(TERT-BUTYLDIPHENYLSILYL)-D-GLUCAL

  • (TERT.-BUTYLDIMETHYLSILYLOXY)ETHANOL
  • 2-(tert-Butyl-dimethylsilanyloxy)-ethanol
  • 2-(t-butyldimethylsiloxy)ethanol
  • 2-(tert-ButyldiMethylsiloxy)ethyl alcohol
  • 2-[(tert-ButyldiMethylsilyl)oxy]-1-ethanol
  • 2-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]ethanol
  • Ethanol, 2-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-
  • 2-tert-Butyldimethylsilyloxyethanol
  • 2-((tert-ButyldiMethylsilyl)oxy)etanol-
  • 2-(tert-Butyldimethylsiloxy)ethanol
  • 2-[[tert-Butyl(dimethyl)silyl]oxy]ethan-1-ol
  • DK025
  • DK448
  • DKFELEX0097
  • DKSI011
  • CB9511523
  • 102229-10-7
  • Aliphatics