Nebivolol hydrochloride

Product Name: Nebivolol hydrochloride
CAS No.: 152520-56-4
Chemical Name: Nebivolol hydrochloride
Synonyms: CS-496;D06622;R-67555;Nebilox;Nebilet;Lobivon;Bystolic;Nebivolo;Narbivolol;NEBIVOLOL HC
CBNumber: CB9649567
Molecular Formula: C22H26ClF2NO4
Formula Weight: 441.9
MOL File: 152520-56-4.mol

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Nebivolol hydrochloride Property

Melting point:: 220-222°C
storage temp.: room temp
solubility: DMSO: ≥20mg/mL
form: powder
color: white to off-white
Merck: 14,6432
Major Application: pharmaceutical
InChIKey: JWEXHQAEWHKGCW-JBFWKIBUNA-N
SMILES: [C@H]([C@@]1([H])CCC2=CC(F)=CC=C2O1)(O)CNC[C@@H]([C@]1([H])CCC2=CC(F)=CC=C2O1)O.Cl |&1:0,1,17,18,r|

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50/53
Safety Statements: 60-61
RIDADR: 3077
WGK Germany: 3
HS Code: 29322090
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002299
Product name: Nebivolol hydrochloride
Purity: CRS, European Pharmacopoeia (EP) Reference Standard
Packaging: 35 mg
Price: $632
Updated: 2026/04/30

Sigma-Aldrich

Product number: N1915
Product name: Nebivolol hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $90.5
Updated: 2026/04/30

Sigma-Aldrich

Product number: PHR3059
Product name: Nebivolol Hydrochloride
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 300mg
Price: $638
Updated: 2026/04/30

Sigma-Aldrich

Product number: 1457833
Product name: Nebivolol hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 150mg
Price: $2390
Updated: 2026/04/30

TCI Chemical

Product number: N0954
Product name: Nebivolol Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 20mg
Price: $71
Updated: 2026/04/30

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Nebivolol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Powder

Uses

Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.

Uses

Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM

Uses

A -Adrenergic blocker. Used as an antihypertensive

Definition

ChEBI: (R,S,S,S)-nebivolol hydrochloride is a hydrochloride obtained by reaction of (R,S,S,S)-nebivolol with one equivalent of hydrochloric acid. It contains a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol hydrochloride.

Biological Activity

Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo .

Biochem/physiol Actions

Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies. It stabilizes membrane and possesses intrinsic sympathomimetic functionality. Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods.

storage

Desiccate at RT

Nebivolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Nebivolol hydrochloride Suppliers

Americas 1 Argentina 1 Australia 1 Austria 1 Belgium 1 Canada 3 China 246 China Hong Kong 1 Czech Republic 1 Europe 1 France 3 Germany 5 Greece 1 India 100 Italy 3 Japan 2 Jordan 1 South Korea 1 United Arab Emirates 1 United Kingdom 7 United States 39 Global 420

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 977
Advantage: 55

Hubei Chenxin Pharmaceutical Co., Ltd.

Tel: 17362916295 17362916295;
Fax: QQ:840947394
Email: w17362916295@163.com
Country: China
ProdList: 3003
Advantage: 58

Pushan Industry (Shaanxi) Co., Ltd.

Tel: 029-81310890 13571859809
Email: info@pushanshiye.com
Country: China
ProdList: 9954
Advantage: 58

NANJING ZENJI PHARMACEUTICALS

Tel: 0512-62750571
Email: marketing@zenjipharma.com
Country: China
ProdList: 421
Advantage: 58

NANJING ZENJI PHARMACEUTICALS

Tel: 0512-62750571
Fax: 025-83172562
Email: marketing@zenjipharma.com
Country: China
ProdList: 421
Advantage: 58

HANGZHOU KELAI BIOMEDICAL TECHNOLOGY Co., Ltd.

Tel: 18957050573 13375780607;18957050573
Email: 752803249@qq.com
Country: China
ProdList: 241
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3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

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View Lastest Price from Nebivolol hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Nebivolol hydrochloride 152520-56-4
Price: US $0.00/g
Min. Order: 1g
Purity: 98%-102%
Supply Ability: 10KGS
Release date: 2025-07-31

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Nebivolol hydrochloride 152520-56-4
Price: US $990.00-800.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-19

Shaanxi Dideu Medichem Co. Ltd

Product: Nebivolol hydrochloride 152520-56-4
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-27

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Narbivolol

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Lobivon

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R-67555

NEBIVOLOLHYDROCHLORIDE(SUBJECTTOPATENTFREE)

a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride

Nebivolol hydrochloride

NEBIVOLOL HC

R 065824 hydrochloride

CS-496

a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

(aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride

D06622

Nebivolol hydrochloride (usan)

(±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)

Nebivolol (Bystolic)

Nebivalate HCl

Bystolic

2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, [2R*[R*[R*(S*)]]]-(±)-

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NebivololHydrochloride&gt

Nebivolol reference substance

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Nebivolol hydrochlorider

Nebivolol hydrochloride Impurities

Nebivolo

Nebivolol Hcl- IP

Nebivolol HCl (R 065824)

R-Nebivolol D4 HCl

Nebivolol HydrochlorideQ: What is Nebivolol Hydrochloride Q: What is the CAS Number of Nebivolol Hydrochloride Q: What is the storage condition of Nebivolol Hydrochloride

TIANFU CHEM--Nebivolol hydrochloride

Nebivolol Hydrochloride (1457833)

2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α'R,2R,2'S)-rel-

(αR,α'R,2R,2'S)-rel-α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-Benzopyran-2-methanol hydrochloride (1:1)

Nebivolol hydrochloride (R-65824)

Hexamidine 2-hydroxyethansulfanonate

R 065824 hydrochloride|||Nebivolol HCl|||R-65824

(S)-1-((R)-6-fluorochroman-2-yl)-2-(((S)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethanol hydrochloride

Nebivolol hydrochloride in methanol

Nebivolol hydrochloride, beta1 antagonist

Nebivolol hydrochloride, 10 mM in DMSO

Nebivolol HCl - Bio-X ?

Nebivolol Hydrochloride 98%

(αR,α'R,2R,2'S)-rel-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride

Nebivolo RRRR/Nebivolol HCl

Nebivolol hydrochlor

Nebivolol hydrochloride salt

152520-56-4

C22H26ClF2NO4

C22H25F2NO4HCl

C22H25F2NO4ClH

C22H23O4F2NHCL