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Nebivolol hydrochloride

Product Name
Nebivolol hydrochloride
CAS No.
152520-56-4
Chemical Name
Nebivolol hydrochloride
Synonyms
CS-496;D06622;R-67555;Nebilox;Nebilet;Lobivon;Bystolic;Nebivolo;Narbivolol;NEBIVOLOL HC
CBNumber
CB9649567
Molecular Formula
C22H26ClF2NO4
Formula Weight
441.9
MOL File
152520-56-4.mol
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Nebivolol hydrochloride Property

Melting point:
220-222°C
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
white to off-white
Merck 
14,6432
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50/53
Safety Statements 
60-61
RIDADR 
3077
WGK Germany 
3
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N1915
Product name
Nebivolol hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$82.1
Updated
2024/03/01
Sigma-Aldrich
Product number
1457833
Product name
Nebivolol hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
150mg
Price
$2590
Updated
2024/03/01
TCI Chemical
Product number
N0954
Product name
Nebivolol Hydrochloride
Purity
>98.0%(HPLC)
Packaging
20mg
Price
$71
Updated
2024/03/01
TCI Chemical
Product number
N0954
Product name
Nebivolol Hydrochloride
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$212
Updated
2024/03/01
Cayman Chemical
Product number
23660
Product name
Nebivolol (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
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Nebivolol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Powder

Uses

A ?-Adrenergic blocker. Used as an antihypertensive

Uses

Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.

Uses

Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM

Definition

ChEBI: (R,S,S,S)-nebivolol hydrochloride is a hydrochloride obtained by reaction of (R,S,S,S)-nebivolol with one equivalent of hydrochloric acid. It contains a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol hydrochloride.

Biological Activity

Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo .

Biochem/physiol Actions

Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies. It stabilizes membrane and possesses intrinsic sympathomimetic functionality. Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods.

storage

Desiccate at RT

Nebivolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Nebivolol hydrochloride Suppliers

Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
1004
Advantage
55
Hubei Chenxin Pharmaceutical Co., Ltd.
Tel
17362916295 17362916295
Fax
QQ:840947394
Email
w17362916295@163.com
Country
China
ProdList
3022
Advantage
58
Jiangxi ravel Biotechnology Co.,Ltd
Tel
185-0276-2003 18502762003;
Email
435918333@qq.com
Country
China
ProdList
2312
Advantage
58
Pushan Industry (Shaanxi) Co., Ltd.
Tel
029-81310890 13571859809
Email
info@pushanshiye.com
Country
China
ProdList
10000
Advantage
58
Wellman Pharmaceutical Group Limited
Tel
027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
4029
Advantage
58
NANJING ZENJI PHARMACEUTICALS
Tel
025-58231105-8151 15190133791;
Email
marketing@zenjipharma.com
Country
China
ProdList
439
Advantage
58
NANJING ZENJI PHARMACEUTICALS
Tel
025-58231105-8151
Fax
025-83172562
Email
marketing@zenjipharma.com
Country
China
ProdList
439
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
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View Lastest Price from Nebivolol hydrochloride manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Nebivolol hydrochloride 152520-56-4
Price
US $990.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-19
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Nebivolol hydrochloride 152520-56-4
Price
US $0.00/g
Min. Order
1g
Purity
98%-102%
Supply Ability
10KGS
Release date
2021-06-24
Shaanxi Dideu Medichem Co. Ltd
Product
Nebivolol hydrochloride 152520-56-4
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%
Supply Ability
2000tons
Release date
2019-12-27

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