Creatine phosphate disodium salt Property

Density 

1.784 at 20℃

vapor pressure 

0.025Pa at 20-50℃

storage temp. 

Inert atmosphere,2-8°C

solubility 

H₂O: 0.1 g/mL, clear, colorless

form 

Powder

color 

White

PH

pH : 8.3 (20% in water)

Water Solubility 

soluble

InChI

InChI=1S/C4H10N3O5P.Na.H/c1-7(2-3(8)9)4(5)6-13(10,11)12;;/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12);;

InChIKey

HUWYWJSJJDCZRQ-UHFFFAOYSA-L

SMILES

C(=N)(NP(O)(O)=O)N(C)CC(=O)O.[NaH]

LogP

-1.17 at 22℃ and pH7

Surface tension

68.63mN/m at 1.034g/L and 20℃

CAS DataBase Reference

922-32-7(CAS DataBase Reference)

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

F 

10

HS Code 

29252900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

Creatine phosphate disodium salt Chemical Properties,Usage,Production

Description

Creatine phosphate belongs to the human body and is the most important type of energy supplier. It can provide energy support for various tissues and organs. In human brain, kidney, cardiac muscle and skeletal muscle, 80% of the energy source is creatine phosphate. In humans, the synthesis of creatine phosphate begins in the kidney organs. A guanidinic acid is formed from arginine and glycine, and then creatine is formed through methylation in the liver. Finally, it is phosphorylated in various cellular tissues. And creatine phosphate is formed. Creatine phosphate disodium salt is a commercial creatine phosphate drug, which has become more and more widely used in acute myocardial infarction in recent years, and has achieved good results.

Uses

Creatine phosphate disodium salt is a white needle-like crystalline powder that is easily soluble in water. In medicine, it can protect the heart muscle by injecting creatine phosphate disodium salt, and can also be used to treat myocardial abnormalities in the ischemic state. creatine phosphate plays an important role in energy metabolism during muscle contraction[3]. The use of creatine phosphate is generally by intravenous injection. Phosphocreatine disodium salt exists as creatine phosphate after entering the body.

Chemical Properties

white powder

Uses

Creatine Phosphate Disodium Salt is an impurity of Creatine(C781483). Creatine can be used in biological study of high fat diets with different ketogenic ratios on hippocampal accumulation of creatine.

Biological Activity

Creatine Phosphate Sodium Salt is a high-energy phosphate compound that serves as a substrate for the determination of creatine kinase, which is used to regenerate ATP during skeletal muscle contraction. It is usually an integral part of the ATP-generating system. As long as enough ATP is present, it can store energy from the mitochondria. When ATP levels are low, the energy from creatine phosphate is transferred to the ADP molecule and then rapidly converted into ATP.

storage

Store at -20°C

Purification Methods

The salt first appears as oily droplets which slowly settle and crystallise. After 12hours the supernatant is clear. Stirring and scratching the flask containing the filtrate brings out additional crystals (0.3-1g) if the salt is kept at 20o for 12hours. Filter it off at room temperature, wash with 3 x 5mL of ice-cold 90% EtOH, then 5mL of absolute EtOH and dry it in a vacuum desiccator (Drierite or CaCl2) for 16-30hours. The hexahydrate (plates) is converted to the tetrahydrate salt (needles) in a vacuum at -10o. [Ennor & Stocken Biochemical Preparations 5 9 1957, Biochem J 43 190 1958, Beilstein 4 III 1170, 4 IV 2425.]