ChemicalBook > CAS DataBase List > 2,3-Difluorobenzyl alcohol

2,3-Difluorobenzyl alcohol

Product Name
2,3-Difluorobenzyl alcohol
CAS No.
75853-18-8
Chemical Name
2,3-Difluorobenzyl alcohol
Synonyms
RARECHEM AL BD 0211;2,3-Difluorophenyl alcohol;2,3-DIFLUOROBENZYL ALCOHOL;2,3-difluoro-Benzenemethanol;(2,3-Difluorophenyl)methanol;2,3-Difluorobenzylalcohol98%;Benzenemethanol, 2,3-difluoro-;2,3-Difluorobenzyl Alcohol >2,3-Difluorobenzyl alcohol,94%;2,3-Difluorobenzyl alcohol 98%
CBNumber
CB9671979
Molecular Formula
C7H6F2O
Formula Weight
144.12
MOL File
75853-18-8.mol
More
Less

2,3-Difluorobenzyl alcohol Property

Boiling point:
101.45°C (rough estimate)
Density 
1.282 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.492(lit.)
Flash point:
201 °F
storage temp. 
Sealed in dry,Room Temperature
form 
Liquid
pka
13.61±0.10(Predicted)
Specific Gravity
1.282
color 
Clear colorless to pale brown
Water Solubility 
Slightly soluble in water.
BRN 
7089243
CAS DataBase Reference
75853-18-8(CAS DataBase Reference)
NIST Chemistry Reference
2,3-Difluorobenzyl alcohol(75853-18-8)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
41-36/37/38
Safety Statements 
26-39-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29062990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
290262
Product name
2,3-Difluorobenzyl alcohol
Purity
94%
Packaging
5g
Price
$55.5
Updated
2022/05/15
TCI Chemical
Product number
D4619
Product name
2,3-Difluorobenzyl Alcohol
Purity
>98.0%(GC)
Packaging
5g
Price
$55
Updated
2025/07/31
TCI Chemical
Product number
D4619
Product name
2,3-Difluorobenzyl Alcohol
Purity
>98.0%(GC)
Packaging
25g
Price
$221
Updated
2025/07/31
TRC
Product number
D451423
Product name
2,3-Difluorobenzyl alcohol
Packaging
250mg
Price
$55
Updated
2021/12/16
SynQuest Laboratories
Product number
2601-3-19
Product name
2,3-Difluorobenzyl alcohol
Purity
98%
Packaging
5G
Price
$36
Updated
2021/12/16
More
Less

2,3-Difluorobenzyl alcohol Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to pale brown liquid

Uses

It is used to produce 1-bromomethyl-2,3-difluoro-benzene with reagent PBr3 and solvent toluene at the temperature of 100°C for 1 hour. 2,3-Difluorobenzyl alcohol may be used in chemical synthesis studies.

Definition

ChEBI: 2,3-difluorobenzyl alcohol is a member of the class of benzyl alcohols that is benzyl alcohol substituted by fluoro groups at positions 2 and 3 respectively. It is an organofluorine compound and a member of benzyl alcohols.

Synthesis

2646-91-5

75853-18-8

Step 1 (MW-Si): sodium borohydride (5.3 g, 140.84 mmol) was slowly added to a methanolic solution (200 mL) of 2,3-difluorobenzaldehyde (20 g, 140.84 mmol) in three batches (each batch was separated by more than 25 min) at 0 °C. The temperature rose to 50°C due to exothermic during the reaction. The reaction mixture was continued to be stirred for 1 hour and then the solvent was removed by distillation under reduced pressure. Subsequently, the residue was extracted by adding ethyl acetate and saturated ammonium chloride solution to the residue. After separation of the organic layer, the aqueous layer was extracted again with ethyl acetate. All organic layers were combined, washed sequentially with water and saturated brine, and then dried with anhydrous sodium sulfate. Finally, 20 g of MW-Si (2,3-difluorobenzyl alcohol) was obtained by vacuum concentration as a colorless liquid, which could be used in subsequent steps without further purification.

References

[1] Patent: WO2014/140279, 2014, A1. Location in patent: Page/Page column 88; 169
[2] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1345 - 1360

2,3-Difluorobenzyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,3-Difluorobenzyl alcohol Suppliers

Americas 1 Canada 1 China 132 Europe 2 France 1 Germany 5 India 7 Italy 1 Japan 3 Spain 1 Switzerland 2 The Netherlands 1 United Kingdom 17 United States 38 Global 212
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2805
Advantage
65
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
021-31038972,31038973 17321035817
Fax
+86-21-51385350
Email
sales@harvest-chem.com
Country
China
ProdList
2816
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Beijing Eternalchem Co,. Ltd.
Tel
010-59484199 18611897322
Email
sales@eternalchem.com
Country
China
ProdList
4383
Advantage
60
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Tianjin Jinyuda Chemical Co., Ltd.
Tel
022-58013646 13011382049
Fax
022-23854368
Email
sales@jinyudachem.com
Country
China
ProdList
1930
Advantage
55
Suzhou Sibian Chemical Technology Co.,Ltd.
Tel
0512-65617459 18915409046
Fax
0512-65617459
Email
sales@sibian-chem.com
Country
China
ProdList
1922
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Wulechem Co., Ltd.
Tel
13761914825
Fax
02131135716
Email
wulesian@wulechem.com
Country
China
ProdList
288
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Modachem Shanghai Co., Ltd
Tel
+86 (0)21 51320687 51371369 1744605818
Fax
+86 (0)21 51371369
Country
China
ProdList
1578
Advantage
58
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
Advantage
55
Nanjing Duolong Bio-tech Co.,Ltd.
Tel
18905173768
Fax
025-83263139
Email
52513593@qq.com
Country
China
ProdList
2331
Advantage
50
Changzhou Tianrui Pharmaceutical Technology Co., Ltd.
Tel
0519-85386832 13382812559
Fax
0519-85386832
Email
sales@cztrchem.com
Country
China
ProdList
1185
Advantage
56
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7991
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9941
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Beijing Hechemist Technology CO.,LTD
Tel
18511709189
Fax
010-58043593
Email
sales@hechemist.com
Country
China
ProdList
2835
Advantage
58
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886750 13927877953
Fax
0751-2886750
Email
3005811397@qq.com
Country
China
ProdList
13305
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6039 18920764717
Email
sales@heowns.com
Country
China
ProdList
23771
Advantage
60
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shanghai FWD Chemicals Limited
Tel
021-54450827 021-54450828
Email
sales@fwdchem.com
Country
China
ProdList
998
Advantage
58
Zhengzhou Alfa Chemical Co.,Ltd
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
ProdList
11784
Advantage
58
Allfluoro pharmaceutical co. ltd.
Tel
+86-400-0216110 +86-15958047586
Fax
0086-21-33275002
Email
sales@allfluoro.com
Country
China
ProdList
11385
Advantage
58
Nanjing Hengbei Chemicals Co., Ltd.
Tel
+86-25-58393656
Fax
+86-25-58393656
Email
sales@hengbeichem.cn
Country
China
ProdList
6854
Advantage
58
More
Less

View Lastest Price from 2,3-Difluorobenzyl alcohol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,3-Difluorobenzyl alcohol 75853-18-8
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-17
Career Henan Chemical Co
Product
2,3-Difluorobenzyl alcohol 75853-18-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-25

75853-18-8, 2,3-Difluorobenzyl alcoholRelated Search:

Florfenicol Ethyl acetate 1,2-Difluorobenzene 3-Fluorobenzyl alcohol Benzyl alcohol 1,3-Difluorobenzene 4-Fluorobenzyl alcohol Transfluthrin ETHYL PENTAFLUOROBENZOATE 2,3-Difluorobenzoic acid Tetrafluorophthalic acid Tetrafluoroterephthalic acid 2,3,4,5-Tetrafluorobenzoic acid METHYL PENTAFLUOROBENZOATE 2,4-Dinitrofluorobenzene O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Pentafluorobenzoic acid 4-AMINO-2,3,5,6-TETRAFLUOROBENZOIC ACID

  • 2,3-DIFLUOROBENZYL ALCOHOL
  • 2,3-Difluorobenzyl alcohol 98%
  • 2,3-Difluorobenzylalcohol98%
  • 2,3-Difluorobenzyl alcohol,94%
  • 2,3-Difluorophenyl alcohol
  • 2,3-difluorobenzyl alcohol / 2,3-difluorobenzyl alcohol
  • (2,3-Difluorophenyl)methanol
  • RARECHEM AL BD 0211
  • 2,3-difluoro-Benzenemethanol
  • 2,3-Difluorobenzyl Alcohol &gt
  • Benzenemethanol, 2,3-difluoro-
  • 75853-18-8
  • ALCOHOL
  • C7 to C8
  • Building Blocks
  • Alcohols
  • Oxygen Compounds
  • Organic Building Blocks
  • Aromatic compound
  • Miscellaneous
  • Alcohols
  • C7 to C8
  • Oxygen Compounds
  • Fluorine series
  • Benzhydrols, Benzyl & Special Alcohols