ChemicalBook > CAS DataBase List > 3,5-Difluoro-4-hydroxybenzaldehyde

3,5-Difluoro-4-hydroxybenzaldehyde

Product Name: 3,5-Difluoro-4-hydroxybenzaldehyde
CAS No.: 118276-06-5
Chemical Name: 3,5-Difluoro-4-hydroxybenzaldehyde
Synonyms: CAS:118276-06-5;2,6-Difluoro-4-formylphenol;3,5-DIFLUORO-4-HYDROXYBENZALDEHYDE;Benzaldehyde,3,5-difluoro-4-hydroxy-;3,5-Difluoro-4-hydroxybenzaldehyde97%;3,5-Difluoro-4-hydroxybenzaldehyde 97%;Benzaldehyde, 3,5-difluoro-4-hydroxy- (9CI)
CBNumber: CB9675038
Molecular Formula: C7H4F2O2
Formula Weight: 158.1
MOL File: 118276-06-5.mol

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3,5-Difluoro-4-hydroxybenzaldehyde Property

Melting point:: 122-124°C
Boiling point:: 198.5±35.0 °C(Predicted)
Density: 1.464±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 5.27±0.23(Predicted)
color: White to Pale Yellow
Sensitive: Air Sensitive
InChI: InChI=1S/C7H4F2O2/c8-5-1-4(3-10)2-6(9)7(5)11/h1-3,11H
InChIKey: SKOYTQILPMNZQO-UHFFFAOYSA-N
SMILES: C(=O)C1=CC(F)=C(O)C(F)=C1
CAS DataBase Reference: 118276-06-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: D447315
Product name: 3,5-Difluoro-4-hydroxybenzaldehyde
Packaging: 250mg
Price: $50
Updated: 2021/12/16

TRC

Product number: D447315
Product name: 3,5-Difluoro-4-hydroxybenzaldehyde
Packaging: 1g
Price: $130
Updated: 2021/12/16

TRC

Product number: D447315
Product name: 3,5-Difluoro-4-hydroxybenzaldehyde
Packaging: 5g
Price: $475
Updated: 2021/12/16

Apolloscientific

Product number: PC8951
Product name: 3,5-Difluoro-4-hydroxybenzaldehyde
Purity: 99%
Packaging: 1g
Price: $38
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD66257
Product name: 3,5-Difluoro-4-hydroxybenzaldehyde
Packaging: 250mg
Price: $55
Updated: 2021/12/16

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3,5-Difluoro-4-hydroxybenzaldehyde Chemical Properties,Usage,Production

Uses

3,5-Difluoro-4-hydroxybenzaldehyde is used in the preparation of (Z)-2,6- difluoro-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenylacetate.

Synthesis

100-97-0

28177-48-2

118276-06-5

The compound was prepared based on the method described by Lawrence et al [29] with the following modification: 2,6-difluorophenol (0.300 g, 2.3 mmol) was dissolved in hexamethylenetetramine (urotropine, 0.323 g, 2.3 mmol) in trifluoroacetic acid (3.5 mL, 45.7 mmol) under argon gas protection and the reaction was carried out at reflux for 15 hours. After completion of the reaction, the mixture was concentrated, mixed with 15 mL of ice water and stirred for 30 min. Subsequently, the aqueous phase was alkalized with Na2CO3 and extracted with dichloromethane. The aqueous phase was further acidified with 1 mol/L HCl, followed by four extractions with dichloromethane. The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure. The final 3,5-difluoro-4-hydroxybenzaldehyde was obtained as a milky white solid (0.212 g, 58% yield) with a melting point of 116-118 °C.

References

[1] Journal of Fluorine Chemistry, 2003, vol. 123, # 1, p. 101 - 108
[2] Journal of Molecular Liquids, 2018, vol. 264, p. 327 - 336
[3] South African Journal of Chemistry, 1997, vol. 50, # 1, p. 40 - 47
[4] Chemical Communications, 2011, vol. 47, # 22, p. 6449 - 6451
[5] Journal of Medicinal Chemistry, 1989, vol. 32, # 2, p. 450 - 455

3,5-Difluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,5-Difluoro-4-hydroxybenzaldehyde manufacturers

Career Henan Chemical Co

Product: 3,5-Difluoro-4-hydroxybenzaldehyde 118276-06-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 97%-99%
Supply Ability: as request
Release date: 2018-12-23

118276-06-5, 3,5-Difluoro-4-hydroxybenzaldehydeRelated Search:

2,5-Dihydroxybenzaldehyde 4-(Trifluoromethyl)benzaldehyde 4-Hydroxybenzaldehyde 3-Hydroxybenzaldehyde 3,5-Dihydroxybenzaldehyde 3,5-Dihydroxybenzoic acid 3-(Trifluoromethyl)benzaldehyde Benzaldehyde 4-Dimethylaminobenzaldehyde 3-Fluoro-4-hydroxybenzaldehyde 3,5-Difluoro-4-methoxybenzaldehyde 3,5-DIFLUORO-4-METHOXYACETOPHENONE 3,5-DIFLUORO-4-METHOXYBENZOIC ACID 3',5'-DIFLUORO-4'-HYDROXYPROPIOPHENONE 2,3,5,6-Tetrafluoro-4-hydroxy-benzoic acid 2,6-Difluoro-4-hydroxybenzaldehyde ,97%,2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE 2,3-Difluoro-4-hydroxybenzaldehyde97% 3',5'-DIFLUORO-4'-METHOXYPROPIOPHENONE

Benzaldehyde, 3,5-difluoro-4-hydroxy- (9CI)

3,5-Difluoro-4-hydroxybenzaldehyde 97%

3,5-Difluoro-4-hydroxybenzaldehyde97%

3,5-DIFLUORO-4-HYDROXYBENZALDEHYDE

2,6-Difluoro-4-formylphenol

Benzaldehyde,3,5-difluoro-4-hydroxy-

CAS:118276-06-5

118276-06-5

Aldehydes

Phenyls & Phenyl-Het

ALDEHYDE

Aromatic Aldehydes & Derivatives (substituted)