tert-Butyl carbazate

Product Name: tert-Butyl carbazate
CAS No.: 870-46-2
Chemical Name: tert-Butyl carbazate
Synonyms: tert-butyl hydrazinecarboxylate;carbazate;BOC-NHNH2;BOC-HYDRAZINE;T-BUTYLCARBAZATE;tert-Butyl N-aminocarbamate;HYDRAZINECARBOXYLIC ACID TERT-BUTYL ESTER;BOC-HYDRAZIDE;TERT-BUTOXYCARBONYL HYDRAZIDE;T-BOC-HYDRAZIDE
CBNumber: CB9686391
Molecular Formula: C5H12N2O2
Formula Weight: 132.16
MOL File: 870-46-2.mol

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tert-Butyl carbazate Property

Melting point:: 39-42 °C (lit.)
Boiling point:: 63-65 °C/0.1 mmHg (lit.)
Density: 1.02
refractive index: 1.4496 (estimate)
Flash point:: 197 °F
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in ethanol and methanol.
pka: 10.74±0.20(Predicted)
form: Crystalline Lumps
color: White to slightly yellow
Sensitive: Moisture Sensitive
BRN: 1756967
InChIKey: DKACXUFSLUYRFU-UHFFFAOYSA-N
CAS DataBase Reference: 870-46-2(CAS DataBase Reference)
EPA Substance Registry System: Hydrazinecarboxylic acid, 1,1-dimethylethyl ester (870-46-2)

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Safety

Hazard Codes: T-F,T,F
Risk Statements: 48-36/37/38-24/25-11
Safety Statements: 45-36/37/39-16-24/25
RIDADR: 1325
WGK Germany: 3
F: 21
TSCA: Yes
HazardClass: 4.1
PackingGroup: III
HS Code: 29280090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H228Flammable solid
Precautionary statements: P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B91005
Product name: tert-Butyl carbazate
Purity: 98%
Packaging: 5g
Price: $38.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: B91005
Product name: tert-Butyl carbazate
Purity: 98%
Packaging: 25g
Price: $79.4
Updated: 2024/03/01

Alfa Aesar

Product number: A12383
Product name: tert-Butyl carbazate, 98+%
Packaging: 25g
Price: $74.2
Updated: 2024/03/01

Alfa Aesar

Product number: A12383
Product name: tert-Butyl carbazate, 98+%
Packaging: 100g
Price: $126.65
Updated: 2024/03/01

Sigma-Aldrich

Product number: B91005
Product name: tert-Butyl carbazate
Purity: 98%
Packaging: 100g
Price: $148
Updated: 2024/03/01

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tert-Butyl carbazate Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow lumps

Uses

Starting material for preparing BOC-azide, a reagent to introduce the BOC amino protection.

Uses

tert-Butyl carbazate is used in a palladium-catalyzed cross-coupling with vinyl halides to prepare N-Boc-N-alkenylhydrazines. It is utilized in solid phase peptide synthesis and in the optical purity determination of alfa-amino aldehyde. It reacts with aldehydes to get hydrazones, which finds application as an intermediate in the synthesis of HIV-1 protease inhibitors. In addition to this, it is used as a starting material for the preparation of BOC-azide, sulfonic and carboxylic hydrazides.

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 2725, 1960 DOI: 10.1021/ja01496a018
Chemical and Pharmaceutical Bulletin, 18, p. 217, 1970 DOI: 10.1248/cpb.18.217

Purification Methods

Distil it in a Claisen flask with a water or oil bath at ca 80o. After a couple of drops have distilled, the carbazate is collected as an oil which solidifies to a snow white solid. It can be crystallised with 90% recovery from a 1:1 mixture of pet ether (b 30-60o) and pet ether (b 60-70o). [Carpino et al. Org Synth Coll Vol V 166 1973, Caprino et al. Org Synth 44 20 1964, Beilstein 3 IV 175.]

tert-Butyl carbazate Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Di-tert-butyl dicarbonate Hydrazine hydrate Isopropyl alcohol

Preparation Products

PYRIDIN-2-YLMETHYL-HYDRAZINE PYRIDIN-3-YLMETHYL-HYDRAZINE (2-METHOXY-1-METHYL-ETHYL)-HYDRAZINE PYRIDIN-4-YLMETHYL-HYDRAZINE CYCLOBUTYLHYDRAZINE 3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID

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tert-Butyl carbazate Suppliers

Australia 1 Belgium 4 Canada 2 China 451 Europe 1 France 2 Germany 14 India 72 Japan 8 Spain 1 Sweden 2 Switzerland 3 The Netherlands 1 United Kingdom 14 United States 52 Global 628

Acros Organics (Part of Thermo Fisher Scientific )

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Email: fo@acros.com
Country: Belgium
ProdList: 3824
Advantage: 58

Alkemi BVBA

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Email: nfo@alkemi.be
Country: Belgium
ProdList: 2201
Advantage: 58

TCI EUROPE N.V.

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Email: sales@tcieurope.be
Country: Belgium
ProdList: 2200
Advantage: 66

Acros Organics

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Email: info@acros.com
Country: Belgium
ProdList: 6772
Advantage: 81

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View Lastest Price from tert-Butyl carbazate manufacturers

Hebei Longbang Technology Co., Ltd

Product: tert-Butyl carbazate 870-46-2
Price: US $6.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20TONS
Release date: 2024-06-03

hebei hongtan Biotechnology Co., Ltd

Product: Tert-Butyl carbazate 870-46-2
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000kg
Release date: 2024-05-13

Hebei Weibang Biotechnology Co., Ltd

Product: tert-Butyl carbazate 870-46-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

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TERT-BUTOXYCARBONYL HYDRAZIDE

TERT-BUTOXYCARBONYLHYDRAZINE

TERT-BOC-HYDRAZIDE

TERT-BUTYLOXYCARBAZATE

tert-butyloxycarbonyl-hydrazide

T-BOC-HYDRAZIDE

T-BUTOXYCARBONYL HYDRAZIDE

T-BUTYLCARBAZATE

T-BUTYLOXYCARBONYL-HYDRAZIDE

tert-Butyl hydrazinocarboxylate

tert-Butylcarbazate,98+%

BOC-HYDRAZIDE 98%

TERT-BUTYL CARBAZATE 99%

tert-Butyl carbazate, 97+%

tert-Butoxycarbonyl hydrazide, Boc-hydrazide

tert-Butyl N-aminocarbamate

N-T-BUTOXYCARBONYL-HYDRAZIDE

CustoM-Made product

tert-Butyl carbaza

tert-butyl hydrazinecarboxylate

1-Boc hydrazine

<i>tert</i>-Butyl carbazate

Hydrazinecarboxylic acid-1,1-dimethyl ester

BOC-Hydrazine tert-Butyl carbazate

Tert-Cutyl Carbazate

tert-Butyl hydrazinoformate

Boc-hydrazide≥ 99% (GC)

Carbazic acid 1,1-dimethylethyl ester

N-Aminocarbamic acid tert-butyl ester

tert-Butyl carbazate,99%

LABOTEST-BB LT00053500

Boc-hydrazine tert-Butoxycarbonylhydrazine Carbazic Acid tert-Butyl Ester

TERT-BUTYL CARBAZATE FOR SYNTHESIS

hydrazinecarboxylicacid,1,1-dimethylethylester

AKOS B028820

Tert-Butyl carbazateCAS

BOC-hydrazide（Tert-Butyl carbazate）

tert-Butyl carbazate,tert-Butoxycarbonyl hydrazide, Boc-hydrazide

tert-Butyl carbazate

tert-Butyl carbazate, 99% 100GR

tert-Butyl carbazate, 99% 500GR

HYDRAZINECARBOXYLIC ACID TERT-BUTYL ESTER

+-BUTYL CARBAZATE

CARBONIC ACID TERT-BUTYL ESTER HYDRAZIDE

CARBAZINIC ACID TERT-BUTYL ESTER

CARBAZIC ACID TERT-BUTYL ESTER

BOC-HYDRAZIDE

BOC-HYDRAZINE

BOC-NHNH2

Baloxavir Impurity 35

ert-Butyl carbazate

tert-Butyl carbazate T-BOC-HYDRAZIDE

tert-Butyl carbazate solution

carbazate

tert-Butyl Carbazate &gt

tert-Butyl carbazate, 99%, for synthesis

N-BOC-HYDRAZINE

1-Boc hydrazine(BOC-NHNH2)