ChemicalBook > CAS DataBase List > 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

Product Name
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
CAS No.
83654-05-1
Chemical Name
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
Synonyms
U-57908;Rg 80267;RHC-80267;RHC 80267, 10 mM in DMSO;RXSVYGIGWRDVQC-UHFFFAOYSA-N;RHC-80267 - CAS 83654-05-1 - Calbiochem;1,6-bis(cyclohexyloximinocarbonyl)hexane;RHC-80267, diacylglycerol lipase inhibitor;1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE;1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane
CBNumber
CB9686432
Molecular Formula
C20H34N4O4
Formula Weight
394.52
MOL File
83654-05-1.mol
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1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Property

Melting point:
118-121℃
Density 
1.21±0.1 g/cm3(Predicted)
RTECS 
GW1485000
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: 9 mg/mL
form 
solid
pka
13.81±0.46(Predicted)
color 
white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R2028
Product name
RHC 80267
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$86.7
Updated
2025/07/31
Sigma-Aldrich
Product number
554994
Product name
RHC-80267
Packaging
10mg
Price
$139
Updated
2025/07/31
Cayman Chemical
Product number
16432
Product name
RHC-80267
Purity
≥95%
Packaging
5mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
16432
Product name
RHC-80267
Purity
≥95%
Packaging
10mg
Price
$53
Updated
2024/03/01
Sigma-Aldrich
Product number
R2028
Product name
RHC 80267
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$486
Updated
2025/07/31
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1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Chemical Properties,Usage,Production

Description

RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules. IC50 in canine platelets is 4 μM.1

Uses

RHC-80267 is a selective inhibitor of DAG lipase, which plays an important role in the production of arachidonic acid.

Definition

ChEBI: N-[6-[[(cyclohexylideneamino)oxy-oxomethyl]amino]hexyl]carbamic acid (cyclohexylideneamino) ester is a carbamate ester and an organonitrogen compound.

General Description

Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.

Biological Activity

Inhibitor of diacylglycerol lipase (IC 50 values are 1.1 and 4 μ M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A 2 . Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC 50 = 4 μ M).

Biochem/physiol Actions

Product does not compete with ATP.

storage

Store at +4°C

References

[1] PAUL W. MANLEY. Anthranilic Acid Amides: A Novel Class of Antiangiogenic VEGF Receptor Kinase Inhibitors[J]. Journal of Medicinal Chemistry, 2002, 45 26: 5687-5693. DOI:10.1021/jm020899q
[2] PAUL WILLIAM MANLEY. Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis[J]. Biochimica et biophysica acta. Proteins and proteomics, 2004, 1697 1: Pages 17-27. DOI:10.1016/j.bbapap.2003.11.010
[3] PAUL W. MANLEY. Anthranilic Acid Amides: A Novel Class of Antiangiogenic VEGF Receptor Kinase Inhibitors[J]. Journal of Medicinal Chemistry, 2002, 45 26: 5687-5693. DOI:10.1021/jm020899q
[4] PAUL WILLIAM MANLEY. Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis[J]. Biochimica et biophysica acta. Proteins and proteomics, 2004, 1697 1: Pages 17-27. DOI:10.1016/j.bbapap.2003.11.010
[5] PAUL W. MANLEY. Anthranilic Acid Amides: A Novel Class of Antiangiogenic VEGF Receptor Kinase Inhibitors[J]. Journal of Medicinal Chemistry, 2002, 45 26: 5687-5693. DOI:10.1021/jm020899q

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Suppliers

China 85 Germany 1 Italy 1 Switzerland 3 United Kingdom 2 United States 15 Global 107
EMMX Biotechnology LLC
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83654-05-1, 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANERelated Search:

Fatostatin A MK-886 EPOXOMICIN (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT N,N'-DIFORMYL-1,6-DIAMINOHEXANE 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Cyclohexanone oxime

  • 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
  • RHC-80267
  • U-57908
  • N,N'-[1,6-Hexanediylbis(iminocarbonyloxy)]bis(cyclohexanimine)
  • 1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane
  • 1,6-bis(cyclohexyloximinocarbonyl)hexane
  • 1,6-bis(Cyclohexyloximinocarbonylamino)hexane, U 57908
  • RHC-80267 - CAS 83654-05-1 - Calbiochem
  • Cyclohexanone, o,o'-(1,6-hexanediylbis(iminocarbonyl))dioxime
  • Rg 80267
  • O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioximecyclohexanone
  • RXSVYGIGWRDVQC-UHFFFAOYSA-N
  • (cyclohexylideneamino) N-[6-[(cyclohexylideneamino)oxycarbonylamino]hexyl]carbamate
  • Cyclohexanone, 1,1'-[O,O'-[1,6-hexanediylbis(iminocarbonyl)]dioxime]
  • Cyclohexanone O-((6-((((cyclohexylideneamino)oxy)carbonyl)amino)hexyl)carbamoyl) oxime
  • 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE ISO 9001：2015 REACH
  • RHC-80267, diacylglycerol lipase inhibitor
  • RHC 80267, 10 mM in DMSO
  • 83654-05-1
  • C20H34N4O4
  • Biochemicals and Reagents
  • BioChemical
  • Enzymes, Inhibitors, and Substrates
  • Diacylglycerol kinase
  • D to K
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Lipid signaling