1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

Product Name: 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
CAS No.: 83654-05-1
Chemical Name: 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
Synonyms: U-57908;Rg 80267;RHC-80267;RHC 80267, 10 mM in DMSO;RXSVYGIGWRDVQC-UHFFFAOYSA-N;RHC-80267 - CAS 83654-05-1 - Calbiochem;1,6-bis(cyclohexyloximinocarbonyl)hexane;RHC-80267, diacylglycerol lipase inhibitor;1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE;1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane
CBNumber: CB9686432
Molecular Formula: C20H34N4O4
Formula Weight: 394.52
MOL File: 83654-05-1.mol

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1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Property

Melting point:: 118-121℃
Density: 1.21±0.1 g/cm3(Predicted)
RTECS: GW1485000
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: 9 mg/mL
form: solid
pka: 13.81±0.46(Predicted)
color: white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R2028
Product name: RHC 80267
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Sigma-Aldrich

Product number: 554994
Product name: RHC-80267
Packaging: 10mg
Price: $159
Updated: 2024/03/01

Alfa Aesar

Product number: J67323
Product name: RHC-80267, 98%
Packaging: 10mg
Price: $138
Updated: 2023/06/20

Cayman Chemical

Product number: 16432
Product name: RHC-80267
Purity: ≥95%
Packaging: 5mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 16432
Product name: RHC-80267
Purity: ≥95%
Packaging: 10mg
Price: $53
Updated: 2024/03/01

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1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Chemical Properties,Usage,Production

Description

RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules. IC50 in canine platelets is 4 μM.1

Uses

RHC-80267 is a selective inhibitor of DAG lipase, which plays an important role in the production of arachidonic acid.

Definition

ChEBI: N-[6-[[(cyclohexylideneamino)oxy-oxomethyl]amino]hexyl]carbamic acid (cyclohexylideneamino) ester is a carbamate ester and an organonitrogen compound.

General Description

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.

Biological Activity

Inhibitor of diacylglycerol lipase (IC 50 values are 1.1 and 4 μ M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A 2 . Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC 50 = 4 μ M).

Biochem/physiol Actions

Product does not compete with ATP.

storage

Store at +4°C

References

1) Southerland and Amin (1982), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; J. Biol. Chem., 257 14006 2) Rindlisbacher et al. (1990), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; J. Neurochem., 54 1247 3) Chandra Sekar et al. (1987), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Arch. Biochem. Biophys., 256 509 4) Levasseur et al. (1984), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; Prostaglandins, 27 673 5) Natarajan et al. (1988), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Biochem. Biophys. Res. Commun., 156 717

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Suppliers

China 72 Germany 1 Italy 1 Switzerland 3 United Kingdom 2 United States 15 Global 94

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83654-05-1, 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANERelated Search:

Fatostatin A MK-886 EPOXOMICIN (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT N,N'-DIFORMYL-1,6-DIAMINOHEXANE 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Cyclohexanone oxime

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

RHC-80267

U-57908

N,N'-[1,6-Hexanediylbis(iminocarbonyloxy)]bis(cyclohexanimine)

1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane

1,6-bis(cyclohexyloximinocarbonyl)hexane

1,6-bis(Cyclohexyloximinocarbonylamino)hexane, U 57908

RHC-80267 - CAS 83654-05-1 - Calbiochem

Cyclohexanone, o,o'-(1,6-hexanediylbis(iminocarbonyl))dioxime

Rg 80267

O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioximecyclohexanone

RXSVYGIGWRDVQC-UHFFFAOYSA-N

(cyclohexylideneamino) N-[6-[(cyclohexylideneamino)oxycarbonylamino]hexyl]carbamate

Cyclohexanone, 1,1'-[O,O'-[1,6-hexanediylbis(iminocarbonyl)]dioxime]

Cyclohexanone O-((6-((((cyclohexylideneamino)oxy)carbonyl)amino)hexyl)carbamoyl) oxime

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE ISO 9001：2015 REACH

RHC-80267, diacylglycerol lipase inhibitor

RHC 80267, 10 mM in DMSO

83654-05-1

C20H34N4O4

Biochemicals and Reagents

BioChemical

Enzymes, Inhibitors, and Substrates

Diacylglycerol kinase

D to K

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

Lipid signaling