4-Methylaniline hydrochloride Property

Melting point:

243-245 °C(lit.)

Density 

1.193 g/cm3

storage temp. 

Store below +30°C.

Water Solubility 

Soluble in water

solubility 

DMSO (Sparingly), Methanol (Slightly)

form 

powder to crystal

color 

White to Gray to Red

BRN 

3557540

Stability:

Hygroscopic

CAS DataBase Reference

540-23-8(CAS DataBase Reference)

EPA Substance Registry System

p-Toluidine hydrochloride (540-23-8)

Safety

Hazard Codes 

T,N

Risk Statements 

23/24/25-36-40-43-50

Safety Statements 

28-36/37-45-61

RIDADR 

UN 2811 6.1/PG 1

WGK Germany 

3

RTECS 

XU7525000

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

29214300

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H351Suspected of causing cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-Methylaniline hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to light beige crystalline powder, crystals

Uses

p-Toluidine Hydrochloride acts as a reagent for the preparation and biological activity of N-acylleucine (arylaminoethyl)amides as non-covalent inhibitors of cathepsin K, L and S. Catalyst in the chemistry of azasteroids.

General Description

Off-white to grayish-white crystals.

Air & Water Reactions

Water soluble. May be sensitive to moisture.

Reactivity Profile

4-Methylaniline hydrochloride reacts with oxidizing and alkali materials. .

Fire Hazard

Flash point data for 4-Methylaniline hydrochloride are not available, but 4-Methylaniline hydrochloride is probably combustible.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also p-TOLUIDINE.

Purification Methods

Crystallise the salt from MeOH containing a few drops of conc HCl or aqueous EtOH. Dry it under vacuum over paraffin chips. [Beilstein 12 II 587, 12 III 2021, 12 IV 1869.]