ChemicalBook > CAS DataBase List > Mesterolone

Mesterolone

Product Name
Mesterolone
CAS No.
1424-00-6
Chemical Name
Mesterolone
Synonyms
proviron;mesterolon;MESTERELONE;testiwop;sh723;NSC-7504;NSC 75054;mesteranum;androviron;mestoranum
CBNumber
CB9691874
Molecular Formula
C20H32O2
Formula Weight
304.47
MOL File
1424-00-6.mol
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Mesterolone Property

Melting point:
208 °C
alpha 
D20 +17.6° (c = 0.875 in CHCl3)
Boiling point:
420.3±45.0 °C(Predicted)
Density 
1.156 g/cm3
refractive index 
17.6 ° (C=0.9, CHCl3)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, sparingly soluble in acetone, in ethyl acetate and in methanol
pka
15.09±0.70(Predicted)
Water Solubility 
3mg/L at 20℃
Merck 
5916
InChI
InChI=1/C20H32O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h12-13,15-18,22H,4-11H2,1-3H3/t12-,13-,15-,16-,17-,18-,19-,20-/s3
InChIKey
UXYRZJKIQKRJCF-TZPFWLJSSA-N
SMILES
[C@@]12([H])CC[C@@]3([H])CC(=O)C[C@H](C)[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])O |&1:0,4,10,12,14,18,20,23,r|
CAS DataBase Reference
1424-00-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
20/21/22-38-19-11-61-60
Safety Statements 
22-24/25-36/37/39-45-53
WGK Germany 
3
RTECS 
BV8063400
HS Code 
29372900
DEA Controlled Substances
CSCN: 4000
CSA SCH: Schedule III
NARC: No
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H351Suspected of causing cancer

H362May cause harm to breast-fed children

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M7655
Product name
Mesterolone
Purity
analytical standard
Packaging
100mg
Price
$95.1
Updated
2024/03/01
Cayman Chemical
Product number
21171
Product name
Mesterolone
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21171
Product name
Mesterolone
Purity
≥95%
Packaging
5mg
Price
$109
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
SHG0006368
Product name
MESTEROLONE
Purity
95.00%
Packaging
250MG
Price
$721.88
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0006368
Product name
MESTEROLONE
Purity
95.00%
Packaging
2.5G
Price
$1815
Updated
2021/12/16
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Mesterolone Chemical Properties,Usage,Production

Description

Mesterolone (Item No. 21171) is an analytical reference standard categorized as an anabolic androgenic steroid. Formulations containing mesterolone have been used in patients with low testosterone or symptoms of aging male syndrome. Mesterolone cannot be aromatized to estrogens, unlike other androgens. This compound is the active ingredient in different pharmaceutical preparations that have been used medically but have also been widely applied in sports in order to improve athlete performance. Mesterolone is regulated as a Schedule III drug in the United States. This product is intended for research and forensic applications.

Chemical Properties

White or yellowish crystalline powder.

Originator

Proviron,Schering,W. Germany,1967

Uses

Mesterolone is a synthetic androgen and a dihydrotestosterone derivative. Mesterolone is rarely used for replacement therapies due to its weak androgenic activity.

Definition

ChEBI: Mesterolone is a 3-oxo-5alpha-steroid. It is a structurally altered DHT hormone possessing the addition of a methyl group at the carbon one position. This allows the hormone to survive oral ingestion by protecting it from hepatic breakdown. This is one of the only oral anabolic steroids that is not C17-alpha alkylated (C17-aa) but instead carries the added methyl group.

Application

Mesterolone is a pharmacological agent that belongs to the group of androgens. It is an oral preparation and has been used in the treatment of infectious diseases, autoimmune diseases, and metabolic disorders. It has also been used as a matrix effect control in biological samples. The biological effects of it are mediated by its direct action on cells or through conversion to testosterone or dihydrotestosterone (DHT). These effects include increasing protein synthesis, promoting bone formation, lowering cholesterol levels, stimulating the production of red blood cells, and decreasing fat deposition.

Manufacturing Process

500 mg of 1α-methyl-androstan-17β-ol-3-one-17-acetate are heated under reflux for 90 minutes in a nitrogen atmosphere in 5 ml of 4% methanolic sodium hydroxide solution. The reaction mixture is then stirred into ice water,the precipitated product filtered with suction and recrystallized from isopropyl ether. 1α-Methyl-androstan-17β-ol-3-one melts at 203.5° to 205°C.

Therapeutic Function

Androgen

General Description

Mesterolone is a synthetic anabolic-androgenic steroid (AAS) and derivative of dihydrotestosterone (DHT). It is inactivated by 3α-hydroxysteroid dehydrogenase in skeleta muscules so it is considered a weak androgen. It is not a substrate for aromatase so it is not converted into estrogen. Mesterolone demonstrated to have minimal effect on sperm counts and levels of FSH or LH. Experiments of mesterolone serving as a potential treatment of depression are still undergoing.

Side effects

The main side effects are acne vulgaris, male pattern baldness, prostate enlargement, increased risk for prostate cancer, and increased risk for developing breast cancer.

Mesterolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Mesterolone Suppliers

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View Lastest Price from Mesterolone manufacturers

CONTIDE BIOTECH CO.,LTD
Product
Mesterolone (Proviron) 1424-00-6
Price
US $0.00/G
Min. Order
1G
Purity
20
Supply Ability
20
Release date
2024-04-11
hebei hongtan Biotechnology Co., Ltd
Product
Mesterolone(Proviron) 1424-00-6
Price
US $12.00-8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2024-05-11
American HealthyMorph LLC
Product
Mesterolone 1424-00-6
Price
US $0.00/Box
Min. Order
1Box
Purity
99%
Supply Ability
1000/week
Release date
2024-12-12

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