N-BOC-1,3-DIAMINO-2-PROPANOL

Product Name: N-BOC-1,3-DIAMINO-2-PROPANOL
CAS No.: 144912-84-5
Chemical Name: N-BOC-1,3-DIAMINO-2-PROPANOL
Synonyms: N-BOC-1,3-DIAMINO-2-PROPANOL;3-(Boc-amino)-1-amino-2-propanol;tert-butyl 3-amino-2-hydroxypropylcarbamate;ert-butylN-(3-amino-2-hydroxypropyl)carbamate;Tert-butyl n-(3-amino-2-hydroxypropyl)carbamate;Carbamic acid,N-(3-amino-2-hydroxypropyl)-, 1,1-dimethylethyl ester;Carbamic acid, (3-amino-2-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI)
CBNumber: CB9697654
Molecular Formula: C8H18N2O3
Formula Weight: 190.24
MOL File: 144912-84-5.mol

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N-BOC-1,3-DIAMINO-2-PROPANOL Property

Melting point:: 77-79 °C
Boiling point:: 350.2±32.0 °C(Predicted)
Density: 1.090±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 12.22±0.46(Predicted)
Appearance: Off-white to light yellow Solid
optical activity: Consistent with structure
InChI: InChI=1S/C8H18N2O3/c1-8(2,3)13-7(12)10-5-6(11)4-9/h6,11H,4-5,9H2,1-3H3,(H,10,12)
InChIKey: LZNOKWJGNPKUSE-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCC(O)CN

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM1050055
Product name: N-BOC-1,3-DIAMINO-2-PROPANOL
Purity: 95.00%
Packaging: 5MG
Price: $497.19
Updated: 2021/12/16

AK Scientific

Product number: 2354AQ
Product name: tert-butyl(3-amino-2-hydroxypropyl)carbamate
Packaging: 1g
Price: $702.8
Updated: 2021/12/16

Ambeed

Product number: A679901
Product name: tert-Butyl(3-amino-2-hydroxypropyl)carbamate
Purity: 95%
Packaging: 5g
Price: $1080
Updated: 2021/12/16

ChemBridge Corporation

Product number: BB-4086959
Product name: tert-butyl(3-amino-2-hydroxypropyl)carbamate
Purity: 95%
Packaging: 10g
Price: $1385
Updated: 2021/12/16

Chemenu

Product number: CM327672
Product name: tert-butylN-(3-amino-2-hydroxypropyl)carbamate
Purity: 95%+
Packaging: 100g
Price: $2187
Updated: 2021/12/16

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N-BOC-1,3-DIAMINO-2-PROPANOL Chemical Properties,Usage,Production

Synthesis

24424-99-5

616-29-5

144912-84-5

The general procedure for the synthesis of tert-butyl (3-amino-2-hydroxypropyl)carbamate from di-tert-butyl dicarbonate and 1,3-diamino-2-propanol was as follows: 0.9 g of 1,3-diamino-2-propanol was added to a reactor equipped with magnetic stirring, and dissolved with 5 mL of 1 M sodium hydroxide solution. Subsequently, 1.0 g of di-tert-butyl dicarbonate was dissolved in 5 mL of 1,4-dioxane and this solution was slowly added dropwise to the reactor. The reaction mixture was stirred at room temperature for 5 hours and then warmed up to 50-65 °C for decompression distillation to remove most of the solvent, and the remaining solvent was dried by a vacuum pump to give a white viscous solid. The crude product was purified by silica gel column chromatography with gradient elution using dichloromethane-methanol-triethylamine (300:30:1, v/v/v) as eluent to give 600 mg of tert-butyl (3-amino-2-hydroxypropyl)carbamate in 69% yield.

References

[1] Patent: CN106893342, 2017, A. Location in patent: Paragraph 0016; 0017
[2] Patent: CN105503920, 2016, A. Location in patent: Paragraph 0011; 0057; 0058
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 2, p. 236 - 246
[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 46, p. 9389 - 9404
[5] Patent: WO2005/66172, 2005, A1. Location in patent: Page/Page column 62

N-BOC-1,3-DIAMINO-2-PROPANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-1,3-DIAMINO-2-PROPANOL Suppliers

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144912-84-5, N-BOC-1,3-DIAMINO-2-PROPANOLRelated Search:

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N-BOC-1,3-DIAMINO-2-PROPANOL

Carbamic acid, (3-amino-2-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI)

tert-butyl 3-amino-2-hydroxypropylcarbamate

Carbamic acid,N-(3-amino-2-hydroxypropyl)-, 1,1-dimethylethyl ester

3-(Boc-amino)-1-amino-2-propanol

ert-butylN-(3-amino-2-hydroxypropyl)carbamate

Tert-butyl n-(3-amino-2-hydroxypropyl)carbamate

144912-84-5

N-BOC