(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

Product Name: (2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
CAS No.: 57561-39-4
Chemical Name: (2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
Synonyms: tert-Butyl 2-hydroxyethyl(methyl)carbamate;Boc,Me-Glycinol;(2-HYDROXY-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER;AKOS 92083;Boc-Sar-OL;N-Boc-N-meth;BOC,ME-N-ET-OH;Boc-N-Me-Gly-OL;BOC-N-ME-AMINOETHANOL;Raffinazine impurity 43
CBNumber: CB9320031
Molecular Formula: C8H17NO3
Formula Weight: 175.23
MOL File: 57561-39-4.mol

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(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER Property

Boiling point:: 120-126°C 4mm
Density: 1.037±0.06 g/cm3(Predicted)
refractive index: 1.4410 to 1.4460
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 14.67±0.10(Predicted)
form: Liquid
color: Colorless to pale yellow
Water Solubility: Soluble in diochloromethane. Slightly soluble in water.
InChI: InChI=1S/C8H17NO3/c1-8(2,3)12-7(11)9(4)5-6-10/h10H,5-6H2,1-4H3
InChIKey: RFDSJHHLGFFVHD-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)N(CCO)C

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Safety

Safety Statements: 24/25
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5685
Product name: N-(tert-Butoxycarbonyl)-N-methyl-2-aminoethanol
Purity: >98.0%(GC)
Packaging: 1g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: B5685
Product name: N-(tert-Butoxycarbonyl)-N-methyl-2-aminoethanol
Purity: >98.0%(GC)
Packaging: 5g
Price: $96
Updated: 2025/07/31

TRC

Product number: B692595
Product name: N-(tert-Butoxycarbonyl)-N-methylethanolamine
Packaging: 25g
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB11657
Product name: N-N-Boc-N-methyl-aminoethanol
Packaging: 25g
Price: $400
Updated: 2021/12/16

Matrix Scientific

Product number: 076245
Product name: N-Boc-N-methyl-aminoethanol
Purity: 95+%
Packaging: 5g
Price: $44
Updated: 2021/12/16

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(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production

Uses

N-Boc-N-methylethanolamine is an substituent in the synthesis of anticancer agent, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription.

Synthesis

109-83-1

24424-99-5

57561-39-4

General procedure: To a solution of 2-(methylamino)ethanol (500 mg, 0.53 mL, 6.66 mmol) in dichloromethane (20 mL) was added di-tert-butyl dicarbonate (1.48 g, 6.79 mmol), and the reaction was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was extracted with saturated aqueous sodium chloride solution and dichloromethane. The organic layers were combined, dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give N-BOC-N-methylaminoethanol (colorless oil, quantitative yield). The product was characterized as follows: 1H NMR (200 MHz, CDCl3) δ 3.74 (q, J = 10.5, 5.2 Hz, 2H), 3.25 (t, J = 5.2 Hz, 2H), 2.91 (s, 3H), 1.45 (s, 9H); mass spectra m/z (relative intensities) 144 (20), 102 (24), 57 (70), 44 (100).

References

[1] Journal of Organic Chemistry, 2000, vol. 65, # 20, p. 6368 - 6380
[2] Patent: US2009/42872, 2009, A1. Location in patent: Page/Page column 19
[3] Patent: US2007/4675, 2007, A1. Location in patent: Page/Page column 92-93
[4] Patent: WO2007/81091, 2007, A1. Location in patent: Page/Page column 26
[5] Patent: WO2011/5028, 2011, A2. Location in patent: Page/Page column 11

(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER Suppliers

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View Lastest Price from (2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER manufacturers

R&D Scientific Inc.

Product: tert-Butyl 2-Hydroxyethyl(methyl)carbamate 57561-39-4
Price: US $790.00/Kg
Min. Order: 0.100Kg
Purity: 98
Supply Ability: 5000 Kg
Release date: 2025-04-29

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-Sar-OL 57561-39-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-20

Sichuan Jiaying Lai Technology Co.,LTD

Product: (2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER 57561-39-4
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-29

57561-39-4, (2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTERRelated Search:

BOC-N-ME-SER-OH Boc-N-methyl-L-leucine BOC-D-METYR(BZL)-OH CHA Boc-N-Me-Val-OH BOC-D-MEPHE-OH BOC-N-ME-TYR-OH Boc-N-methyl-D-leucine BOC-N-Methyl-L-alanine Boc-N-Methyl-L-isoleucine Boc-N-methyl-L-phenylalanine BOC-N-methyl-D-alanine tert-Butyl N-(5-hydroxypyridin-3-yl)carbamate BOC-D-MEVAL-OH N-BOC-1,3-DIAMINO-2-PROPANOL tert-butyl 5-oxopyrrolidin-3-ylcarbamate Boc-7-aminoheptan-1-ol (R)-N-Boc-glutamic acid-1,5-dimethyl ester tert-butyl (5-hydroxypentyl)(methyl)carbamate

tert-Butyl 2-hydroxyethyl(methyl)carbamate

Boc,Me-Glycinol

N-t-Butyloxycarbonyl-N-methyl-aminoethanol, N-t-Butyloxycarbonyl-N-methyl-glycinol

N-Boc-N-methyl-aminoethanol

N-T-BUTYLOXYCARBONYL-N-METHYL-AMINOETHANOL

N-(TERT-BUTOXYCARBONYL)-N-METHYLETHANOLAMINE

N-TERT-BUTYLOXYCARBONYL-N-METHYL-AMINOETHANOL

N-BOC-N-METHYL-ETHANOLAMINE

TERT-BUTYL N-(2-HYDROXYETHYL)-N-METHYLCARBAMATE

BOC-N-ME-AMINOETHANOL

BOC,ME-N-ET-OH

(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

(2-HYDROXY-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER

2-(N-METHYL-N-BOC-AMINO)ETHANOL

2-(N-BOC-METHYLAMINO)ETHANOL

AKOS 92083

N-Methyl N-Boc-ethanolaMine

(2-hydroxyethyl)MethylcabaMic acid

2-(Methylamino)ethanol, N-BOC protected

2-(N-Boc-N-methylamino)ethanol

2-(Methylamino)ethanol, N-BOC protected 97%

tert-Butyl (2-hydroxyethyl)methylcarbamate, N-(tert-Butoxycarbonyl)-N-methylglycinol

N-Methyl-N-(2-hydroxyethyl)carbamic acid tert-butyl ester

Ethanolamine, N-(t-butoxycarbonyl)-N-methyl-

N-(2-hydroxyethyl)-N-methyl-carbamic acid tert-butyl ester

N-(2-hydroxyethyl)-N-methylcarbamic acid tert-butyl ester

Boc-N-Me-Gly-OL

N-(tert-Butoxycarbonyl)-N-methyl-2-aminoethanol

methyl(2-hydroxyethyl)carbamic acid tert-butyl ester

TERT-BUTYL N-(2-HYDROXYETHYL)-N-M

Carbamic acid, N-(2-hydroxyethyl)-N-methyl-, 1,1-dimethylethyl ester

N-Boc-N-methylethanolamine,95%

N-(tert-Butoxycarbonyl)-N-methylglycinol

N-Boc-N-meth

N-Boc-N-methyl-2-aminoethanol

(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1

Boc-Sar-OL

Raffinazine impurity 43

Revefenacin Impurity 44

57561-39-4