BOC-D-MEVAL-OH

Product Name: BOC-D-MEVAL-OH
CAS No.: 89536-85-6
Chemical Name: BOC-D-MEVAL-OH
Synonyms: BOC-D-MEVAL-OH;Boc-N-Me-D-Val;BOC-N-ME-D-VAL-OH;BOC-N-ME-D-VALINE;BOC-N-METHYL-D-VALINE;BOC-D-MEVAL-OH USP/EP/BP;BOC-N-ALPHA-METHYL-D-VALINE;Boc-N-methyl-D-valine≥ 98% (HPLC);N-ALPHA-T-BOC-N-ALPHA-METHYL-D-VALINE;N-[(tert-Butoxy)carbonyl]-N-methyl-D-valine
CBNumber: CB8448222
Molecular Formula: C11H21NO4
Formula Weight: 231.29
MOL File: 89536-85-6.mol

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BOC-D-MEVAL-OH Property

Boiling point:: 322℃
Density: 1.069
Flash point:: 140℃
storage temp.: Sealed in dry,2-8°C
form: Solid
pka: 4.03±0.10(Predicted)
color: White to off-white
optical activity: Consistent with structure

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Safety

HazardClass: IRRITANT
HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: T204543
Product name: (R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylbutanoicAcid
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Usbiological

Product number: 264446
Product name: Boc-N-methyl-D-valine
Packaging: 1g
Price: $408
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB43278
Product name: Boc-N-methyl-D-valine
Packaging: 5G
Price: $353
Updated: 2021/12/16

Apolloscientific

Product number: OR963882
Product name: Boc-N-methyl-D-valine
Purity: 97%
Packaging: 5g
Price: $398
Updated: 2021/12/16

Chem-Impex

Product number: 03822
Product name: Boc-N-methyl-D-valine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 25G
Price: $448
Updated: 2021/12/16

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BOC-D-MEVAL-OH Chemical Properties,Usage,Production

Uses

(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylbutanoic acid is a valine derivative[1].

Synthesis

22838-58-0

74-88-4

13850-91-4

N-(tert-butoxycarbonyl)-D-valine (5 g, 11.5 mmol) was dissolved in THF (69 mL, 0.35 M) at 0 °C, followed by the addition of iodomethane (11.45 mL, 8 eq.). Under stirring, 60% NaH mineral oil dispersion (2.76 g, 3 eq.) was slowly added. The reaction mixture was stirred vigorously at room temperature overnight, after which it was diluted with ether (70 mL) and the reaction was quenched by the slow addition of water (50 mL) at 0 °C. The organic and aqueous layers were separated and the aqueous layer was extracted twice with ether (2 x 30 mL). The pH of the aqueous layer was adjusted to approximately 2 by adding saturated saline dropwise (tested using pH paper), followed by extraction with ethyl acetate (4 × 100 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuum. An oily product (4.46 g, 84% yield) was obtained, which was pure enough for the next step of the reaction. For further purification, an analytically pure sample was obtained as a white fluffy solid by fast column chromatography (silica gel, 3%-5% methanol/dichloromethane). When only 3 equivalents of iodomethane were used under similar conditions, a residue of raw material remained at the end of the reaction, probably due to competitive precipitation of the disodium salt.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

BOC-D-MEVAL-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-D-MEVAL-OH Suppliers

China 73 Germany 3 India 1 Japan 3 United Kingdom 3 United States 12 Global 95

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alabiochem Tech.Co., Ltd.

Tel: 512-58900862 400-0707518
Fax: 0086-512-56765862
Email: sales@alabiochem.com
Country: China
ProdList: 970
Advantage: 59

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
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Lavem Chine Pharm Company

Tel: 028-62070218 18190869852
Fax: 86-28-8527-5264
Email: sales@lavemc.com
Country: China
ProdList: 214
Advantage: 67

ChemPep, Inc.

Tel: +1 (888) 615-9178 / (561) 791-8787
Fax: +1 (561) 791-8728
Email: service@chempep.com
Country: United States
ProdList: 2138
Advantage: 57

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View Lastest Price from BOC-D-MEVAL-OH manufacturers

Career Henan Chemical Co

Product: BOC-D-MEVAL-OH 89536-85-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 10Tons
Release date: 2020-02-19

89536-85-6, BOC-D-MEVAL-OHRelated Search:

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BOC-N-ALPHA-METHYL-D-VALINE

D-Valine,N-[(1,1-diMethylethoxy)carbonyl]-N-Methyl-

BOC-N-METHYL-D-VALINE

BOC-N-ME-D-VALINE

BOC-N-ME-D-VAL-OH

BOC-D-MEVAL-OH

N-ALPHA-T-BOC-N-ALPHA-METHYL-D-VALINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-D-VALINE

N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-D-VALINE

N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-D-VALINE

(R)-2-[(tert-Butoxycarbonyl)(methyl)amino]-3-methylbutanoic acid

N-[(tert-Butoxy)carbonyl]-N-methyl-D-valine

Boc-N-methyl-D-valine≥ 98% (HPLC)

(2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}-3-methylbutanoic acid

Boc-N-Me-D-Val

BOC-D-MEVAL-OH USP/EP/BP

89536-85-6

amino acids