ChemicalBook > CAS DataBase List > BOC-D-MEVAL-OH

BOC-D-MEVAL-OH

Product Name
BOC-D-MEVAL-OH
CAS No.
89536-85-6
Chemical Name
BOC-D-MEVAL-OH
Synonyms
BOC-D-MEVAL-OH;Boc-N-Me-D-Val;BOC-N-ME-D-VAL-OH;BOC-N-ME-D-VALINE;BOC-N-METHYL-D-VALINE;BOC-D-MEVAL-OH USP/EP/BP;BOC-N-ALPHA-METHYL-D-VALINE;Boc-N-methyl-D-valine≥ 98% (HPLC);N-ALPHA-T-BOC-N-ALPHA-METHYL-D-VALINE;N-[(tert-Butoxy)carbonyl]-N-methyl-D-valine
CBNumber
CB8448222
Molecular Formula
C11H21NO4
Formula Weight
231.29
MOL File
89536-85-6.mol
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BOC-D-MEVAL-OH Property

Boiling point:
322℃
Density 
1.069
Flash point:
140℃
storage temp. 
Sealed in dry,2-8°C
form 
Solid
pka
4.03±0.10(Predicted)
color 
White to off-white
optical activity
Consistent with structure
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Safety

HazardClass 
IRRITANT
HS Code 
2924190090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
T204543
Product name
(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylbutanoicAcid
Packaging
500mg
Price
$60
Updated
2021/12/16
Usbiological
Product number
264446
Product name
Boc-N-methyl-D-valine
Packaging
1g
Price
$408
Updated
2021/12/16
Chem-Impex
Product number
03822
Product name
Boc--methyl-D-valine
Purity
≥ 98% (HPLC)
Packaging
250MG
Price
$25.9
Updated
2021/12/16
Chem-Impex
Product number
03822
Product name
Boc-N-methyl-D-valine,98%(HPLC)
Purity
98%(HPLC)
Packaging
1G
Price
$28
Updated
2021/12/16
Matrix Scientific
Product number
042434
Product name
Boc-Nalpha-methyl-D-valine
Packaging
1g
Price
$35
Updated
2021/12/16
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BOC-D-MEVAL-OH Chemical Properties,Usage,Production

Uses

(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylbutanoic acid is a valine derivative[1].

Synthesis

22838-58-0

74-88-4

13850-91-4

N-(tert-butoxycarbonyl)-D-valine (5 g, 11.5 mmol) was dissolved in THF (69 mL, 0.35 M) at 0 °C, followed by the addition of iodomethane (11.45 mL, 8 eq.). Under stirring, 60% NaH mineral oil dispersion (2.76 g, 3 eq.) was slowly added. The reaction mixture was stirred vigorously at room temperature overnight, after which it was diluted with ether (70 mL) and the reaction was quenched by the slow addition of water (50 mL) at 0 °C. The organic and aqueous layers were separated and the aqueous layer was extracted twice with ether (2 x 30 mL). The pH of the aqueous layer was adjusted to approximately 2 by adding saturated saline dropwise (tested using pH paper), followed by extraction with ethyl acetate (4 × 100 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuum. An oily product (4.46 g, 84% yield) was obtained, which was pure enough for the next step of the reaction. For further purification, an analytically pure sample was obtained as a white fluffy solid by fast column chromatography (silica gel, 3%-5% methanol/dichloromethane). When only 3 equivalents of iodomethane were used under similar conditions, a residue of raw material remained at the end of the reaction, probably due to competitive precipitation of the disodium salt.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

BOC-D-MEVAL-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-D-MEVAL-OH Suppliers

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View Lastest Price from BOC-D-MEVAL-OH manufacturers

Career Henan Chemical Co
Product
BOC-D-MEVAL-OH 89536-85-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%HPLC
Supply Ability
10Tons
Release date
2020-02-19

89536-85-6, BOC-D-MEVAL-OHRelated Search:

Boc-N-Me-Val-OH BOC-N-Methyl-L-alanine Boc-N-Methyl-L-isoleucine Boc-N-methyl-L-phenylalanine BOC-N-methyl-D-alanine Boc-N-Me-D-HomoPhe-OH BOC-N-ME-SER-OH Boc-N-methyl-L-leucine BOC-D-METYR(BZL)-OH CHA BOC-D-MEPHE-OH BOC-N-ME-TYR-OH BOC-L-MEVAL-OH DCHA (S)-BOC-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID BOC-D-MEVAL-OH BOC-D-MELEU-OH BOC-N-ME-D-ALLO-ILE-OH [1S-, 2R-, 5R-]3-Aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 3-tert-butyl ester BOC-(R)-ALPHA-BENZHYDRYL-PROLINE

  • BOC-N-ALPHA-METHYL-D-VALINE
  • D-Valine,N-[(1,1-diMethylethoxy)carbonyl]-N-Methyl-
  • BOC-N-METHYL-D-VALINE
  • BOC-N-ME-D-VALINE
  • BOC-N-ME-D-VAL-OH
  • BOC-D-MEVAL-OH
  • N-ALPHA-T-BOC-N-ALPHA-METHYL-D-VALINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-D-VALINE
  • N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-D-VALINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-D-VALINE
  • (R)-2-[(tert-Butoxycarbonyl)(methyl)amino]-3-methylbutanoic acid
  • N-[(tert-Butoxy)carbonyl]-N-methyl-D-valine
  • Boc-N-methyl-D-valine≥ 98% (HPLC)
  • (2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}-3-methylbutanoic acid
  • Boc-N-Me-D-Val
  • BOC-D-MEVAL-OH USP/EP/BP
  • 89536-85-6
  • amino acids