Boc-N-Methyl-L-isoleucine

Product Name: Boc-N-Methyl-L-isoleucine
CAS No.: 52498-32-5
Chemical Name: Boc-N-Methyl-L-isoleucine
Synonyms: BOC-MELLE-OH;BOC-MEILE-OH;Boc-N-Me-Ile;BOC-L-MELLE-OH;BOC-L-MEILE-OH;BOC-N-ME-ILE-OH;Boc-N-Me-L-Ile-OH;BOC-N-ME-ISOLEUCINE;BOC-N-METHYL-L-ILE-OH;Boc-N-ethyl-L-Isoleucine
CBNumber: CB6747521
Molecular Formula: C12H23NO4
Formula Weight: 245.32
MOL File: 52498-32-5.mol

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Boc-N-Methyl-L-isoleucine Property

Boiling point:: 338.2±21.0 °C(Predicted)
Density: 1.053±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
pka: 4.05±0.22(Predicted)
form: Solid
color: White to off-white
optical activity: Consistent with structure
BRN: 4251277
InChI: InChI=1S/C12H23NO4/c1-7-8(2)9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t8-,9-/m0/s1
InChIKey: HTBIAUMDQYXOFG-IUCAKERBSA-N
SMILES: C(O)(=O)[C@H]([C@@H](C)CC)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference: 52498-32-5(CAS DataBase Reference)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B601123
Product name: BOC-N-Methyl-L-isoleucine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 264713
Product name: Boc-N-methyl-L-isoleucine
Packaging: 2g
Price: $343
Updated: 2021/12/16

Chem-Impex

Product number: 02655
Product name: Boc--methyl-L-isoleucine
Purity: ≥ 99% (TLC)
Packaging: 1G
Price: $31.1
Updated: 2021/12/16

Activate Scientific

Product number: AS88065
Product name: Boc-N-methyl-L-isoleucine
Purity: 95% ee
Packaging: 1g
Price: $56
Updated: 2021/12/16

Chem-Impex

Product number: 02655
Product name: Boc-N-methyl-L-isoleucine,99%(TLC)
Purity: 99%(TLC)
Packaging: 5G
Price: $104.38
Updated: 2021/12/16

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Boc-N-Methyl-L-isoleucine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Boc-N-methyl-L-isoleucine (Boc-N-Me-Ile-OH) is a peptide products and can be used as a precursor in organic synthesis and pharmaceuticals[1].

Synthesis

13139-16-7

74-88-4

53462-50-3

N-(tert-butoxycarbonyl)-L-isoleucine (1.24 g, 5.4 mmol, 1.0 eq.) was dissolved in 35 mL of tetrahydrofuran (THF), cooled to 0 °C and sodium hydride (60% dispersed in mineral oil; 0.64 g, 16.1 mmol, 3.0 eq.) was added slowly. Iodomethane (6.1 g, 42 mmol, 8.0 eq.) was then added and the reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, ether was added and the organic layer was washed twice with deionized water. The combined aqueous layers were adjusted to pH 3 with citric acid and extracted with ethyl acetate (EtOAc). The combined organic phases were washed sequentially with sodium thiosulfate (Na2S2O3) solution and saturated brine and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed under reduced pressure to afford (2S,3S)-2-((tert-butoxycarbonyl)(methyl)amino)-3-methylpentanoic acid as a colorless oil (1.18 g, 90% yield). The product was characterized by infrared spectroscopy (IR), nuclear magnetic resonance hydrogen spectroscopy (1H NMR), nuclear magnetic resonance carbon spectroscopy (13C NMR), and high-resolution mass spectrometry (HRMS) to confirm the correct structure. The specific optical rotation [α]20D was +2.6 (c 1.8, acetic acid).

References

[1] KazuhiroIrie, et al. Isolation and biosynthesis of (?)-indolactam I, a new congener of indole alkaloid tumor promoter teleocidins. Tetrahedron Letters, 1990, 7337-7340.

Boc-N-Methyl-L-isoleucine Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-N-Methyl-L-isoleucine Suppliers

China 92 France 1 Germany 4 India 1 Japan 4 Switzerland 2 United Kingdom 3 United States 16 Global 123

Sichuan Jisheng Biopharmaceutical Co.,Ltd.

Tel: +86-0833-2598983 +86-18086877136
Fax: +86-833-2598903
Email: Nyx-peptide@jsjpharm.cn
Country: China
ProdList: 308
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
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Country: China
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Alabiochem Tech.Co., Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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Country: China
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Chemsky (shanghai) International Co.,Ltd

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Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

ChemPep, Inc.

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Beijing HuaMeiHuLiBiological Chemical

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Country: China
ProdList: 12335
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9ding chemical ( Shanghai) Limited

Tel: 4009209199
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Country: China
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Advantage: 56

ShenZhen InnoSyn Biotech Co.,Ltd

Tel: 0755-28351685 18503098468
Fax: +86-755-28466854
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Country: China
ProdList: 602
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Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

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View Lastest Price from Boc-N-Methyl-L-isoleucine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Boc-N-methyl-L-isoleucine 52498-32-5
Price: US $2.00-5.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons
Release date: 2025-07-10

Shanghai Getian Industrial Co., LTD

Product: Boc-N-Methyl-L-isoleucine 52498-32-5
Price: US $23.00-19.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 10000box
Release date: 2024-05-11

52498-32-5, Boc-N-Methyl-L-isoleucineRelated Search:

Methyl acrylate Kresoxim-methyl N-Carbobenzyloxyglycine Bensulfuron methyl Methylparaben METHYL THIOPHENE-2-CARBOXYLATE 1,1'-Carbonyldiimidazole L-Isoleucine Boc-Aib-OH Thiophanate-methyl BOC-ILE-OH 1/2H2O BOC-GLY-LEU-OH Methyl FMOC-ARG(ME,PBF)-OH Parathion-methyl Carbonyl iron powder Methyl bromide DIMETHYL-P-NITROPHENYLPHOSPHATE

BOC-N-METHYL-L-ILE-OH

BOC-N-METHYL-L-ISOLEUCINE

BOC-N-ME-ILE-OH

BOC-N-ME-ISOLEUCINE

BOC-MEILE-OH

BOC-MELLE-OH

BOC-N-ALPHA-METHYL-L-ISOLEUCINE

BOC-L-MEILE-OH

BOC-L-MELLE-OH

N-ALPHA-T-BOC-N-ALPHA-METHYL-L-ISOLEUCINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-ISOLEUCINE

N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-ISOLEUCINE

N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-ISOLEUCINE

N-ALPHA-TERT-BUTYLOXYCABONYL-N-ALPHA-METHYL-L-ISOLEUCINE

N-alpha-t-Butyloxycarbonyl-N-alpha-methy-L-isoleucine

NALPHA-tert-Butoxycarbonyl-N-methyl-L-isoleucine

N-tert-Butyloxycarbonyl-N-methyl-L-isoleucine

(2S,3S)-2-(tert-butoxycarbonyl(methyl)amino)-3-methylpentanoic acid

(2S,3S)-3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pentanoic acid

Boc-N-Me-Ile

Boc-N-Me-L-Ile-OH

Boc-N-methyl-L-isoleucine≥ 99% (TLC)

3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid

N-tert-Butoxycarbonyl-N-methylisoleucine

L-Isoleucine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-

(2S,3S)-3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pentanoicaci

Boc-N-Methyl-L-isoleucine USP/EP/BP

Boc-N-ethyl-L-Isoleucine

Boc-N-α-Methyl-L-isoleucine

Boc-N-Methyl-L-isoLeu-OH

52498-32-5

Specialty Synthesis

N-Methyl Amino Acids

Peptide Synthesis

Unnatural Amino Acid Derivatives

amino acids

Amino Acid Derivatives