HARMANE

Product Name: HARMANE
CAS No.: 486-84-0
Chemical Name: HARMANE
Synonyms: HARMAN;1-METHYL-9H-PYRIDO[3,4-B]INDOLE;1-METHYL-PYRIDO[3,4-B]INDOLE;Aribin;ARIBINE;HARMANE;Indoter;Loturine;NSC 54439;Locuturin
CBNumber: CB9698060
Molecular Formula: C12H10N2
Formula Weight: 182.22
MOL File: 486-84-0.mol

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HARMANE Property

Melting point:: 235-238 °C(lit.)
Boiling point:: 305.62°C (rough estimate)
Density: 1.1485 (rough estimate)
refractive index: 1.6266 (estimate)
storage temp.: Store at RT
solubility: methanol: soluble50mg/ml
pka: 7.37, 14.6(at 25℃)
form: Solid
color: White to Dark Brown
Water Solubility: 1523g/L(20 ºC)
Merck: 13,4630
BRN: 143898
LogP: 3.100
CAS DataBase Reference: 486-84-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21-36/37/38
Safety Statements: 22-24/25-36-26
RIDADR: 1544
WGK Germany: 3
RTECS: UV0280000
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: LD50 i.p. in mice: 50 mg/kg (Sigg)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 103276
Product name: Harmane
Purity: 98%
Packaging: 1g
Price: $246
Updated: 2024/03/01

Cayman Chemical

Product number: 29613
Product name: Harmane
Packaging: 250mg
Price: $56
Updated: 2021/12/16

Cayman Chemical

Product number: 29613
Product name: Harmane
Packaging: 500mg
Price: $91
Updated: 2021/12/16

Cayman Chemical

Product number: 29613
Product name: Harmane
Packaging: 100mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 29613
Product name: Harmane
Packaging: 1g
Price: $226
Updated: 2024/03/01

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HARMANE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry.
It was used to study interactions of norharman and harman with DNA.
It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.

Uses

Harman alkaloid like harmane, harmine, harmalol, harmaline obtained from Banisteriopsis caapi L. showed cytotoxicity, antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vulgaris and Candida albicans.

Definition

ChEBI: An indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, P ssiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A.

Synthesis Reference(s)

The Journal of Organic Chemistry, 37, p. 1429, 1972 DOI: 10.1021/jo00974a030
Tetrahedron, 49, p. 3325, 1993 DOI: 10.1016/S0040-4020(01)90161-9

General Description

Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.
It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.
Blood harmane concentration is elevated in essential tremor, late-life neurological disease.

Biological Activity

Proposed as the endogenous ligand for imidazoline binding sites. Binds to I 1 -sites in rat kidney with an IC 50 of 31 nM, and I 2 -sites with a K i of 49 nM. In vivo, produces a dose-dependent hypotension that is reversed by efaroxan (2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole hydrochloride ). Also a potent inhibitor of monoamine oxidases A and B (I 50 values are 0.5 and 5 μ M respectively).

Biochem/physiol Actions

I1 imidazoline binding site agonist.

storage

Room temperature

HARMANE Preparation Products And Raw materials

Raw materials

Preparation Products

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HARMANE Suppliers

Belgium 1 Canada 1 China 89 Europe 1 Germany 2 India 2 Japan 2 Switzerland 4 United Kingdom 7 United States 26 Global 135

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View Lastest Price from HARMANE manufacturers

Career Henan Chemical Co

Product: Harmane 486-84-0
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

486-84-0, HARMANERelated Search:

HARMINE HYDROCHLORIDE SERPENTINE HYDROGEN TARTRATE HARMOL HYDROCHLORIDE HARMANE HARMANE HYDROCHLORIDE,harmane hcl BANISTERINE MONOHYDRATE HARMOL HYDROCHLORIDE DIHYDRATE Pyridine Indole Vasicine 9H-PYRIDO[3,4-B]INDOLE HARMANE-1,2,3,4-TETRAHYDRO-3-CARBOXYLIC ACID HARMANE FREE BASE HARMANE(SECONDARY STANDARD) ZERENEX E/6026463 HARMINE METHYL IODIDE BROMOHARMINE HBR HARMANE METHYL IODIDE

HARMANE(SH)

1-METHYL-PYRIDO[3,4-B]INDOLE

2-Methyl-β-carboline

2-METHYL-B-CARBOLINE

2-METHYL-BETA-CARBOLINE

1-METHYL-9H-PYRIDO[3,4-B]INDOLE

1-METHYL-9H-PYRIDOL[3,4-B]INDOLE

HARMAN

HARMANE

ARIBINE

1-Methyl-9H-pyrido[3,4-b]indole, 2-Methyl-β-carboline, Aribine

Harmane,98%

Zygofabagine

HarmaneAribine1-Methyl-9H-pyrido[3,4-b]indole

Indoter

NSC 54439

1-methyl-9H-$b-carboline

1-methyl-β-carboline

1-methyl-3,4-dihydro-2H-pyrido[3,4-b]indole

METHYLCARBOLINE

METHYL-4-CARBOLINE

HARMANE ( 1-METHYL-9H-PYRIDO[3,4-B]INDOLE)

Aribine~1-Methyl-9H-pyrido[3,4-b]indole

Harmane,99%

9H-Pyrido3,4-bindole, 1-methyl-

HARMON(EXTRACTFROMPEGANUMHARMALAROOTS)

TIMTEC-BB SBB003735

1-Methyl-9H-beta-carboline

1-Methyl-9H-pyrid(3,4-b)indole

1-Methyl-9H-β-carboline

1-Methyl-beta-carboline

1-Methylnorharman

3-Methyl-4-carboline

4-b)indole,1-methyl-9h-pyrido(

Aribin

Locuturin

Locuturine

Loturine

Passiflorin

Pyridobindole, L-methyl-

Harman-d4

Harmane, beta-Carboline. Imidazoline ligand. MAO inhibitor.

486-84-0

488-84-0

Building Blocks

Carbazoles

Heterocyclic Building Blocks

Indoles

Mutagenesis Research Chemicals

Heterocyclic Compounds

Indole Derivatives