Pilsicainide hydrochloride

ChemicalBook > CAS DataBase List > Pilsicainide hydrochloride

Pilsicainide hydrochloride

Product Name: Pilsicainide hydrochloride
CAS No.: 88069-49-2
Chemical Name: Pilsicainide hydrochloride
Synonyms: Pilsinic;Rizumcote;Alisrythm;Tatsupilljin;PILSICAININIDE;Pilsicainide hydrochoride;Pilsicainide-Hydrochlordie;Pilzicainide hydrochloride;PILSICAINIDE HYDROCHLORIDE;Pilsicainide hydrochloride USP/EP/BP
CBNumber: CB9699294
Molecular Formula: C17H24N2O
Formula Weight: 272.39
MOL File: 88069-49-2.mol

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Pilsicainide hydrochloride Property

Melting point:: 212-214°
storage temp.: room temp
solubility: Chloroform (Slightly), Water (Slightly)
form: powder
color: white to beige

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Safety

RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2933.99.7000
Toxicity: LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0026
Product name: Pilsicainide hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $97.5
Updated: 2023/06/20

Sigma-Aldrich

Product number: P0026
Product name: Pilsicainide hydrochloride
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $382
Updated: 2023/06/20

TCI Chemical

Product number: P2634
Product name: Pilsicainide Hydrochloride
Packaging: 50MG
Price: $154
Updated: 2024/03/01

TCI Chemical

Product number: P2634
Product name: Pilsicainide Hydrochloride
Packaging: 250MG
Price: $456
Updated: 2024/03/01

TRC

Product number: P441508
Product name: Pilsicainide Hydrochloride
Packaging: 10mg
Price: $45
Updated: 2021/12/16

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Pilsicainide hydrochloride Chemical Properties,Usage,Production

Description

Pilsicainide hydrochloride is a new pynolizidine lidocaine derivative with antiarrhythmic activity. It is the first pharmaceutical product introduced by Suntory and was solely developed in Japan. The compound is reported to be highly effective in the treatment of premature ventricular contraction. It has no anticholinergic or CNS activity and is not as likely as other class 1C antiarrhythmics to have restricted indications.

Originator

Suntory (Japan)

Uses

Pilsicainide hydrochloride has been used as a sodium channel blocker:

to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
to study its effects on Ca²⁺?release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
to study its electrophysiological effects on the guinea pig atrium

brand name

Sunrhythm

Biochem/physiol Actions

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.

Pilsicainide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pilsicainide hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Pilsicainide hydrochloride 88069-49-2
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-11

Career Henan Chemical Co

Product: Pilsicainide hydrochloride 88069-49-2
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-21

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APIs